Search Clinical Trials in the European Union

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1741-1760 of 1,782 trials

Heart Patients: Reduced Dose of Prasugrel

We are studying whether a lower dose of prasugrel is safe and effective for patients after heart procedures. The trial also looks at how well patients stick to this treatment compared to the usual approach.

Acute and Chronic Coronary SyndromeMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Bone Health: Everolimus and Exercise for Postmenopausal Women

We are studying if a combination of a medication and resistance training can improve bone formation in healthy postmenopausal women. This research may help in understanding better ways to support bone health.

Healthy Elderly Women3-6 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementGynecology and ObstetricsOrthopedics and Traumatology

Onychomycosis: DexULac® Treatment Study

We are studying how well DexULac® works for treating nail fungal infections and its impact on patients' quality of life. This trial will help us understand the effectiveness and safety of this treatment over time.

Nail Fungus (Onychomycosis)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Spinocerebellar Ataxia SCA27B: Fampridine Study

We are investigating whether fampridine can help improve movement and daily activities in patients with spinocerebellar ataxia SCA27B. This study will also assess its effects on quality of life and overall health.

Spinocerebellar Ataxia1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNeurology

Cemiplimab for Advanced Adrenocortical Cancer

We are studying whether cemiplimab can help patients with advanced adrenocortical cancer maintain their health after initial treatment. This trial focuses on those who have not experienced disease progression.

Adrenocortical Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Platysma Prominence: NT 201 Treatment Study

We are investigating whether NT 201 can safely reduce moderate to severe platysma prominence in adults compared to a placebo. This study aims to find out if this treatment can improve appearance and confidence.

Moderate to Severe Platysma Prominence3-6 monthsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesDermatology

Kidney Transplant: Reduced Immunosuppression for Older Adults

We are studying whether a lower dose of immunosuppressive medication is as effective and safe as the standard dose for older adults after kidney transplantation. This may help improve their overall health and quality of life.

End-stage Renal Disease1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Glioblastoma: Intraoperative Photodynamic Therapy with Pentalafen®

We are studying a new light-based treatment for adults with grade IV glioblastoma during surgery. The goal is to evaluate its safety and how well it works in reducing tumor response.

Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Dengue Vaccine Qdenga: Antibody Response Study

We are examining how the Qdenga vaccine affects antibody levels for other flavivirus infections in Swedish travelers. This study aims to see if vaccination leads to higher antibody levels that could interfere with diagnostic tests.

Healthy Participants3-6 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesAllergologyHematologyInfectious Diseases

Cemiplimab and Imiquimod for High-Risk Basal Cell Carcinoma

We are studying a combination of cemiplimab, imiquimod, and laser therapy for patients with high-risk cutaneous basal cell carcinoma. The goal is to evaluate safety and how well this treatment works before surgery.

Skin Cancer (Basal Cell Carcinoma)>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesDermatologyOncology

Fluid Management in Critically Ill Adults: CRUSADERS Trial

We are studying whether reducing sodium and chloride in fluids helps critically ill adults have better health outcomes. This includes looking at effects on organ support needs and overall survival.

Healthy Participants>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNephrology

Inflammatory Rheumatic Diseases: JAK Inhibitor Dose Reduction Study

We are exploring if lowering the dose of JAK inhibitors is as effective as keeping the current dose for patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis in low disease activity. This study will also look at safety and how many patients can successfully reduce their medication.

Rheumatoid Arthritis, Psoriatic Arthritis, and Axial Spondyloarthritis1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineRheumatology

Tonsillectomy Pain Relief: Ropivacaine vs. Lidocaine

We are comparing two local anesthetics to see which one better reduces pain after tonsillectomy. This study aims to find the most effective option for managing postoperative discomfort.

Chronic Tonsillitis6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOtolaryngology

Rapamycin Cream for Port Wine Stains

We are studying whether two strengths of rapamycin cream can improve the appearance of port wine stains in individuals after laser therapy. Participants will compare the effects of the cream to a placebo over several weeks.

Port Wine Stain≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesDermatology

Postoperative Pain Relief: High Dose Dexamethasone for Lung Surgery

We are studying whether a higher dose of Dexamethasone can reduce pain after video-assisted thoracoscopic surgery in patients who typically experience high pain. This trial compares a high dose to a standard lower dose to find the best pain management approach.

Lung Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPulmonology

Choline Alfoscerate for Elderly with Subthreshold Depression

We are studying whether choline alfoscerate can help improve symptoms of subthreshold depression in elderly patients. The trial also looks at its effects on cognitive symptoms and apathy.

Under Threshold Depression in the Elderly1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPsychiatry

Etrasimod in Breastfeeding Women

We are studying how the medication etrasimod is absorbed into the blood and breast milk of healthy lactating women. This research will help us understand its safety and potential effects on breastfeeding infants.

Ulcerative Colitis1-2 yearsSafety phase (I)No PlaceboStandard MedicinesGastroenterologyGynecology and Obstetrics

Learning Dynamics: Atomoxetine Study

We are investigating how a low dose of atomoxetine affects learning and emotional states in healthy adults. This study aims to understand its impact on learning tasks and emotional well-being.

Healthy Participants>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPsychiatry

Pomalidomide for Chronic Hepatitis B Infection

We are studying the safety of pomalidomide in people with chronic hepatitis B. The trial also looks at how this medication may improve immune responses and liver health.

Hepatitis B Virus Infection6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHepatologyInfectious Diseases

Parkinson's Disease: Lecigon® Therapy

We are studying a new treatment combining levodopa and entacapone for people with Parkinson's disease. The goal is to see if it helps reduce certain symptoms and improve overall well-being compared to standard treatments.

Parkinson's Disease>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesNeurologyPsychiatry