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381-400 of 525 trials

Actinic Keratosis: Keramod Gel vs. Aldara Cream

We are studying whether Keramod Gel works better than Aldara Cream for treating actinic keratosis in adults. The trial will also assess safety and how well patients tolerate each treatment.

Actinic Keratosis3-6 monthsEfficacy phase (II)≤5 visits No Placebo Investigational MedicinesDermatology

Functional Dyspepsia: Rikkunshito Study

We are investigating whether Rikkunshito can help relieve symptoms in patients with functional dyspepsia. The study also looks at how it may affect the digestive lining and overall gut function.

Functional Dyspepsia3-6 monthsConfirmation phase (III)≤5 visits Post-Trial Drug Access Investigational Medicines Cost ReimbursementGastroenterologyInternal Medicine

Alcohol-Associated Hepatitis: Alpha-1 Antitrypsin Treatment

We are studying whether intravenous Alpha-1 Antitrypsin can reduce inflammation in patients with severe alcohol-associated hepatitis. The trial also looks at its safety and effects on liver health.

Alcohol-Associated Hepatitis3-6 monthsEfficacy phase (II)≤5 visits No Placebo Standard MedicinesHepatologyInternal Medicine

Chronic Low Back Pain: Antibiotic Treatment Study

We are studying whether a three-month course of amoxicillin can help people with chronic low back pain and specific MRI changes. This trial compares the antibiotic treatment to a placebo to see if it offers any benefits.

Non-Specific Low Back Pain1-2 yearsMonitoring phase (IV)≤5 visits Post-Trial Drug Access Standard MedicinesInfectious DiseasesOrthopedics and Traumatology

Oxybutynin for Boys with Posterior Urethral Valves

We are studying whether early treatment with oxybutynin improves bladder function in boys after surgery for posterior urethral valves. The trial also looks at the safety of the medication and its effects on urinary tract infections.

Urethral Posterior Valve>2 yearsEfficacy phase (II)≤5 visits No Placebo Standard MedicinesPediatricsUrology

Acute Kidney Injury: Angiotensin Receptor Blocker Study

We are studying whether an angiotensin receptor blocker can improve heart and kidney health in patients recovering from acute kidney injury after ICU discharge. This trial will help us understand its effects on overall health and safety.

Acute Kidney Injury>2 yearsConfirmation phase (III)≤5 visits Standard MedicinesCardiologyInternal MedicineNephrology

Chickenpox Vaccine Study for Children Aged 12 to 15 Months

We are evaluating a new chickenpox vaccine to see how well it works and its safety compared to the standard Varivax vaccine in healthy children. This study aims to ensure that the new vaccine provides a strong immune response.

Chickenpox6-12 monthsConfirmation phase (III)≤5 visits No Placebo Standard Medicines Cost Reimbursement Partially RemoteInfectious DiseasesPediatrics

Small Cell Lung Cancer: Sacituzumab Govitecan vs. Standard Care

We are studying a new treatment called sacituzumab govitecan for patients with previously treated extensive stage small cell lung cancer. The goal is to see if it works better and is safer than current standard treatments.

Extensive Stage Small Cell Lung CancerConfirmation phase (III)≤5 visits Post-Trial Drug Access No Placebo Standard Medicines Cost Reimbursement Partially RemoteOncology

Posttraumatic Headache: Botulinum Toxin A Study

We are investigating whether botulinum toxin A can safely reduce the number of headache days for individuals with posttraumatic headaches. The study also looks at biological markers to see if they can predict treatment success.

Post-Traumatic Headache3-6 monthsConfirmation phase (III)≤5 visits Standard Medicines Cost Reimbursement Partially RemoteInternal MedicineNeurology

Primary Biliary Cholangitis: Golexanolone Study

We are testing a new medication, golexanolone, for individuals with primary biliary cholangitis who have significant fatigue and cognitive difficulties. The study aims to evaluate its safety and effects on daily life and cognitive function.

Primary Biliary Cholangitis3-6 monthsSafety phase (I)Efficacy phase (II)≤5 visits Investigational MedicinesHepatologyInternal Medicine

Chronic Lung Disease in Premature Babies: OHB-607 Study

We are testing a new drug to see if it helps reduce lung disease in extremely premature infants compared to standard care. The study aims to improve their overall health and development.

Chronic Lung Disease6-12 monthsEfficacy phase (II)≤5 visits No Placebo Standard Medicines Cost Reimbursement Partially RemotePediatricsPulmonology

Dystonia: Botulinum Toxin for Arm Tremors

We are exploring how different tests and imaging techniques can help determine the effectiveness of botulinum toxin for treating arm tremors in people with dystonia. This study aims to improve treatment options for those affected.

Dystonic Tremor Syndrome6-12 monthsMonitoring phase (IV)≤5 visits Post-Trial Drug Access No Placebo Standard Medicines Cost ReimbursementNeurology

Crohn's Disease: Adalimumab Treatment Study

We are comparing a new approach using adalimumab for newly diagnosed Crohn's disease patients against standard treatments. The goal is to see which method is safer and more effective in the long run.

Crohn's Disease3-6 monthsMonitoring phase (IV)≤5 visits Post-Trial Drug Access No Placebo Standard Medicines Partially RemoteGastroenterologyInternal Medicine

Chronic Myeloid Leukemia: Asciminib Treatment Study

We are studying Asciminib for patients with Chronic Myeloid Leukemia who have the T315I mutation and have not responded to ponatinib. The trial aims to see how well it works and how safe it is.

Chronic Myeloid Leukemia>2 yearsEfficacy phase (II)≤5 visits Post-Trial Drug Access No Placebo Standard Medicines Partially RemoteOncology

Hydroxychloroquine for Early Systemic Sclerosis

We are studying whether adding hydroxychloroquine to standard treatments helps improve symptoms in people with early systemic sclerosis. The trial will assess its safety and effectiveness compared to a placebo.

Systemic Sclerosis1-2 yearsConfirmation phase (III)≤5 visits Standard MedicinesInternal MedicineRheumatology

Serotonin and Decision-Making: A Behavioral Study

We are investigating how serotonin influences learning and decision-making in individuals. The study also looks at how personal traits like perfectionism and impulsivity relate to these behaviors.

Healthy Participants≤3 monthsMonitoring phase (IV)≤5 visits Standard MedicinesPsychiatry

CAR T Cell Therapy for Acute Leukemia in Young Patients

We are studying a new treatment using donor-derived CAR T cells for children and young adults with recurrent acute leukemia. The trial aims to assess the safety and effectiveness of this therapy after previous stem cell transplantation.

Recurrent Acute Lymphocytic Leukaemia>2 yearsEfficacy phase (II)≤5 visits No Placebo Investigational MedicinesHematologyOncology

ANCA-Vasculitis: Corticosteroid Dosing Study

We are investigating if taking corticosteroids twice daily helps patients with ANCA-vasculitis maintain better blood sugar levels. This study will measure glucose control using continuous monitoring.

ANCA-associated VasculitisRapid-Progressive Glomerulonephritis≤3 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visits No Placebo Standard MedicinesEndocrinologyRheumatology

Cryoglobulinemia Vasculitis: Belimumab Study

We are studying whether belimumab can help people with non-infectious active cryoglobulinemia vasculitis compared to a placebo. The goal is to see if it improves symptoms and overall health.

Cryoglobulinemia Vasculitis6-12 monthsEfficacy phase (II)≤5 visits Standard Medicines Cost ReimbursementInfectious DiseasesRheumatology

Wrist Osteoarthritis: Microfat and PRP Injection Study

We are testing whether injections of your own fat and platelet-rich plasma can help relieve pain in wrist osteoarthritis compared to standard surgery. This study aims to see if the new treatment is just as effective and safe.

Wrist Osteoarthritis>2 yearsEfficacy phase (II)≤5 visits No Placebo Investigational MedicinesOrthopedics and TraumatologyRheumatology

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