Search Clinical Trials in the European Union

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441-460 of 525 trials

Brain Aneurysms: Acetylsalicylic Acid Study

We are studying whether acetylsalicylic acid can lower the risk of stroke and improve cognitive function in patients undergoing treatment for unruptured brain aneurysms. This trial compares ASA with a placebo to assess its safety and effectiveness.

Unruptured Cerebral Aneurysm>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteNeurology

Endoscopic Sleeve Gastroplasty: Impact of Proton Pump Inhibitors

We are studying how proton pump inhibitors affect the success of endoscopic sleeve gastroplasty in people seeking weight loss. We also want to learn about their effects on quality of life and metabolic health.

Obesity1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Knee Cartilage Damage: UC-MSC Treatment

We are studying a new treatment using stem cells from umbilical cord tissue for people with cartilage damage in the knee. The trial aims to evaluate the safety and effectiveness of this approach.

Knee Cartilage Defect1-2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Advanced NSCLC: Roginolisib with Dostarlimab

We are studying a new treatment combination for patients with advanced non-squamous lung cancer who have not responded to standard therapies. The trial will evaluate safety and early signs of effectiveness.

Advanced Non-Squamous Non-Small Cell Lung CancerSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncologyPulmonology

Crohn's Disease: New Cellular Treatment for Fistulas

We are studying a new injection of fat-derived cells for people with complex perianal Crohn's fistulas. The goal is to see if this treatment helps heal fistulas better than a placebo.

Crohn's Disease>2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Hemophilia A: Efanesoctocog Alfa Treatment Study

We are studying the long-term effects of efanesoctocog alfa on joint health in people with hemophilia A. The trial aims to see how well it prevents joint bleeds and improves quality of life.

Haemophilia A1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOrthopedics and Traumatology

Cystic Fibrosis: Inhaled Teicoplanin Study

We are evaluating the safety and tolerability of inhaled Teicoplanin for cystic fibrosis patients with persistent Staphylococcus aureus infections. The study aims to see if it can improve lung function and reduce infection levels.

Cystic Fibrosis with Staphylococcus Aureus Infection1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Chronic Urticaria: Briquilimab Study

We are studying the long-term safety and effectiveness of briquilimab in people with chronic urticaria. This trial includes participants from earlier studies to see how well the treatment works over time.

Chronic UrticariaEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesAllergologyDermatology

Graves' Ophthalmopathy: Diclofenac vs. Simvastatin

We are studying whether diclofenac or simvastatin can help patients with mild to moderate Graves' ophthalmopathy. The trial aims to assess the activity of the disease and its progression to more severe forms.

Graves' Ophthalmopathy6-12 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesEndocrinologyOphthalmology

Hydrocortisone Treatment in Pancreatoduodenectomy Surgery

We are studying whether hydrocortisone infusions can help reduce complications after pancreatoduodenectomy surgery. This trial compares the effects of hydrocortisone to a placebo in patients undergoing this procedure.

Pancreatic Resection>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Kidney Health After Transplant: Dapagliflozin Study

We are studying how dapagliflozin affects kidney structure and inflammation in patients with impaired kidney function one year after transplantation. This research may help us understand better treatments for kidney transplant recipients.

Chronic Kidney Disease (CKD)3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyNephrology

Infant Immunity to Whooping Cough: Maternal Vaccination Study

We are studying how vaccines given to pregnant women affect their infants' immunity to whooping cough. Our goal is to find out what factors influence the transfer of protective antibodies from mothers to their babies.

Whooping Cough>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsInfectious DiseasesInternal Medicine

Midgut Neuroendocrine Tumors: Lu177-Dotatate Treatment Schedule

We are studying whether giving Lu177-Dotatate every 16 weeks can lower serious side effects for patients with advanced midgut neuroendocrine tumors. This trial compares the new schedule to the standard treatment given every 8 weeks.

Small Intestine Neuroendocrine Tumor>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyOncology

Septic Shock: Comparing Sodium Lactate and Saline Solutions

We are studying how two different intravenous fluids affect blood flow and acid-base balance in patients with septic shock. This research may help improve treatment options for this serious condition.

Septic Shock>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicinePulmonology

Cardiac AL Amyloidosis: PET/CT Imaging Study

We are studying a new non-invasive imaging method to diagnose cardiac AL amyloidosis in patients with a specific type of protein in their blood. This research aims to see if this method is as effective as traditional invasive tests.

Cardiac Amyloidosis1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Alzheimer’s Disease: NTRX-07 Treatment Study

We are investigating the safety and tolerability of NTRX-07 in people with mild cognitive impairment or mild to moderate Alzheimer's disease. This study aims to understand how well the treatment works and its effects on patients.

Mild Cognitive Impairment (MCI)Mild to Moderate Alzheimer's Disease (AD)≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesNeurology

Essential Tremor: BP1.4979 Treatment Study

We are testing a new medication, BP1.4979, for adults with essential tremor to see if it helps reduce symptoms and improve quality of life. The study will also check how safe the treatment is for patients.

Essential Tremor1-2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Premature Ejaculation: BP1.4979 Study

We are testing a new medication for adult men with primary premature ejaculation to see if it improves ejaculatory control and sexual satisfaction compared to a placebo.

Premature Ejaculation3-6 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemotePsychiatryUrology

Oxytocin and Trust Learning in Attachment Development

We are exploring how oxytocin may influence trust learning and cognitive flexibility in a virtual reality setting. This study aims to understand its effects on social bonding and learning processes.

Healthy Children>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsStandard MedicinesPsychiatry

Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder

We are studying whether a high dose of psilocybin can help reduce heavy drinking in people with severe alcohol use disorder during inpatient rehabilitation. This trial also examines the safety and effects on mental health and cognitive function.

Severe Alcohol Use Disorder6-12 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPsychiatry