Search Clinical Trials in the European Union

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181-200 of 552 trials

Tonsillitis Treatment: Antibiotic vs. No Treatment

We are studying whether an antibiotic can help reduce symptoms in patients with severe tonsillitis who test negative for Streptococcus group A. This trial compares the antibiotic to usual care without antibiotics.

Tonsilitis>2 yearsMonitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngology

Kidney Health in Type 2 Diabetes: Empagliflozin and Finerenone Study

We are exploring how well two medications work for kidney health in people with type 2 diabetes. This remote trial aims to personalize treatment based on individual responses.

Type 2 DiabetesAlbuminuria≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteDiabetologyInternal MedicineNephrology

Primary IgA Nephropathy: Long-Term Study of Iptacopan

We are evaluating the long-term safety and tolerability of iptacopan in adults with primary IgA nephropathy. This study follows participants who have completed an earlier trial to see how well the treatment works over time.

IgA Nephropathy>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineNephrology

Erythema Migrans: Saccharomyces boulardii Probiotic Study

We are studying the effects of a probiotic on gut health in patients taking antibiotics for erythema migrans. The goal is to see if it helps prevent diarrhea and improves gut balance during treatment.

Erythema Migrans6-12 monthsMonitoring phase (IV)≤5 visitsInvestigational MedicinesGastroenterologyInfectious Diseases

Ovarian Stimulation Methods for Embryo Accumulation

We are comparing two approaches to ovarian stimulation in patients preparing for embryo testing. The goal is to see if one method produces more healthy embryos than the other.

Female InfertilityMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Atrial Fibrillation: Rivaroxaban Monotherapy Study

We are exploring the safety of rivaroxaban in patients with atrial fibrillation who have had a heart procedure. This study aims to see if this treatment is a viable option for these patients.

Coronary Artery DiseasePercutaneous Coronary InterventionAtrial Fibrillation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Prednisolone Transfer in Breast Milk: A Study for Breastfeeding Mothers

We are investigating how prednisolone, used for inflammation, transfers into breast milk and affects breastfeeding infants. This study aims to measure medication levels in both mothers and their babies to ensure safety.

Rheumatoid ArthritisSystemic Lupus ErythematosusMyositis≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePediatrics

Cardiac Device Implantation: Local vs. Regional Anesthesia

We are comparing local anesthesia with a specific regional block to see which provides better comfort for patients undergoing cardiac device implantation. This study also looks at any side effects and the need for extra pain relief.

Implantation of Cardiac Devices1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal MedicineOtolaryngology

Septic Shock: Early Use of Vasopressin

We are studying whether starting vasopressin treatment earlier helps improve kidney function in patients with septic shock. This trial aims to see if it reduces the need for kidney support and other complications in the ICU.

Septic Shock1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNephrologyPulmonology

Ovarian Stimulation for Poor Responders: CFA vs. Modified Natural Cycles

We are comparing a single cycle of a new medication with multiple natural cycles in women who may not respond well to fertility treatments. The goal is to see which method leads to better quality embryos and higher chances of pregnancy.

Subfertility3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Crohn's Disease: New Treatment Target Study

We are investigating if aiming for complete healing of all bowel layers improves outcomes for patients with active Crohn's disease. This study compares different treatment strategies to see which is more effective.

Crohn's Disease1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

TMJ Arthritis: Cortisone Injection vs. Arthrocentesis

We are comparing the effectiveness of a cortisone injection and a procedure called arthrocentesis for relieving pain in people with TMJ arthritis. We also want to see how these treatments affect mouth opening and if other factors play a role in recovery.

Temporomandibular Joint Arthritis3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOrthopedics and Traumatology

Systemic Lupus Erythematosus: Belimumab Study

We are studying the effects of belimumab in adults with early systemic lupus erythematosus to see if it helps improve their condition and reduce steroid use.

Systemic Lupus Erythematosus>2 yearsMonitoring phase (IV)16-20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteRheumatology

Kidney Function: Non-Radioactive Measurement Methods

We are evaluating a new non-radioactive method for measuring kidney function in comparison to traditional radioactive techniques. This study aims to ensure accurate assessments while minimizing radiation exposure.

Chronic Kidney Disease3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementInternal MedicineNephrology

Avian Influenza Vaccine: Immune Response Study

We are studying how well a new avian influenza vaccine triggers immune responses in people, especially those with prior seasonal flu vaccinations. This research aims to understand its effectiveness against various H5N1 virus strains.

Avian Influenza and Seasonal Influenza1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Cytisine vs. Nicotine Replacement Therapy for Smokers with Chronic Kidney Disease

We are studying whether cytisine can help nicotine-dependent patients with chronic kidney disease quit smoking more effectively than traditional nicotine replacement therapy. This trial will also look at any side effects from both treatments.

Nicotine DependenceChronic Kidney DiseaseMonitoring phase (IV)No PlaceboStandard MedicinesNephrologyPsychiatry

Heart Attack Treatment: EVOLocumab Study

We are studying whether adding evolocumab to standard cholesterol management helps reduce serious heart-related events in patients recently hospitalized for a heart attack. This trial aims to improve outcomes for those affected by acute myocardial infarction.

High Cholesterol>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

TAVI Patients: Ticagrelor vs Aspirin Study

We are comparing the safety and effectiveness of Ticagrelor and Aspirin for patients after Transcatheter Aortic Valve Implantation. This study aims to see which treatment may lead to fewer serious health events and complications.

Aortic Stenosis>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal Medicine

Long-Term Safety Study of Dabrafenib and Trametinib

We are evaluating the long-term safety of dabrafenib and trametinib for patients who have benefited from these treatments in previous studies. This study helps ensure continued access to these medications for those who need them.

Non-Small Cell Lung CancerMetastatic Melanoma1-2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

C3 Glomerulopathy: Iptacopan Study

We are studying the long-term safety and effectiveness of iptacopan for individuals with C3 glomerulopathy or idiopathic immune-complex-membranoproliferative glomerulonephritis. This research aims to understand how well the treatment works in improving kidney health.

C3 Glomerulopathy>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineNephrology