Search Clinical Trials in the European Union

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201-220 of 552 trials

Radial Nerve Block: Opioid Tolerant Individuals

We are studying how long a radial nerve block lasts in people who are tolerant to opioids versus those who are not. This may help improve pain management for patients with opioid use.

Postoperative PainMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Crohn's Disease: Vedolizumab with Upadacitinib

We are studying whether a combination of vedolizumab and upadacitinib helps improve symptoms in adults with moderately to severely active Crohn's disease compared to vedolizumab alone.

Crohn's Disease>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Cardiovascular Disease: Gene Analysis for Statin Treatment

We are studying whether a gene analysis strategy can help people at risk of cardiovascular disease better tolerate statins and reduce side effects. This trial compares this approach to standard treatment methods.

Patients at Risk of Cardiovascular Disease6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Preventing Opioid-Induced Constipation in Advanced Cancer Patients

We are comparing two laxatives to see which one better prevents constipation in patients with advanced cancer starting opioid pain treatment. This study will also assess quality of life and side effects.

Advanced Cancer≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOncology

ILUVIEN® Eye Implant for Children with Uveitis

We are studying the safety and effectiveness of the ILUVIEN® eye implant in children aged 6 to under 18 with recurrent non-infectious uveitis. This research aims to understand how well the implant works and any possible side effects.

Posterior Uveitis>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementOphthalmologyPediatrics

Tick-Borne Encephalitis: Novel Cytokine Release Assay

We are studying a new test to measure immune responses to Tick-Borne Encephalitis in healthy and immunosuppressed individuals. This research aims to improve understanding of how well the immune system responds to the virus and vaccination.

Tick-borne Encephalitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyInfectious Diseases

Ovarian and Breast Cancer: zAvatar Test Study

We are exploring whether the zAvatar test can help guide treatment decisions for patients with relapsed ovarian cancer and metastatic breast cancer. This study compares outcomes from the zAvatar test approach to standard care.

Breast CancerOvarian CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Bipolar Disorder Type II: Lithium vs. Lamotrigine Study

We are comparing the effects of lithium and lamotrigine on mood stabilization in people with bipolar disorder type II. The goal is to see which treatment may better reduce symptoms and improve daily functioning.

Bipolar Disorder, Type II1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemotePsychiatry

Psoriasis Management: Proactive Drug Monitoring Study

We are comparing proactive drug monitoring to standard care for people with moderate to severe psoriasis. The goal is to see if proactive monitoring helps maintain better disease control and improves quality of life.

Moderate-to-Severe Psoriasis1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyDermatology

Sepsis Treatment: Meropenem vs. Piperacillin/Tazobactam

We are comparing two antibiotics to see which one may help critically ill adults with sepsis survive better and improve their health outcomes.

Septic ShockSepsis6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Pain Management in Heart Surgery: Interpectoral-Pectoserratus Block

We are studying a new pain relief technique for patients undergoing minimally invasive aortic valve replacement. The goal is to see if it improves pain control and recovery compared to a standard approach.

Aortic Valve Disease>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCardiologyOtolaryngology

Rheumatoid Arthritis: JAK Inhibitor Dose Tapering Study

We are exploring whether reducing the dose of JAK inhibitors helps maintain low disease activity in rheumatoid arthritis patients. This study will also look at the impact on pain, function, and overall quality of life.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesRheumatology

Chronic Rhinosinusitis with Nasal Polyps: Dupilumab Study

We are exploring how Dupilumab may improve nasal barrier function in patients with Chronic Rhinosinusitis with nasal polyps. This study compares the effects of treatment on nasal cells from patients and healthy controls.

Chronic Rhinosinusitis with Nasal PolypsChronic Rhinosinusitis without Nasal Polyps>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyOtolaryngology

Testosterone Supplementation for Obese Men with Type 2 Diabetes

We are studying whether intramuscular testosterone can reduce liver fat in obese men with low testosterone and type 2 diabetes. This trial will also look at the long-term effects on metabolic health.

HypogonadismType 2 Diabetes Mellitus (T2DM)Prediabetes>2 yearsMonitoring phase (IV)Post-Trial Drug AccessInvestigational MedicinesDiabetologyEndocrinologyInternal Medicine

Diabetic Macular Edema: Faricimab Treatment Study

We are exploring whether Faricimab can improve vision in patients with diabetic macular edema. The study also examines changes in eye health and treatment frequency over 12 months.

Diabetic Macular Edema>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyOphthalmology

Liver Cirrhosis: Stopping Proton-Pump Inhibitors

We are studying whether stopping proton-pump inhibitors helps or harms patients with liver cirrhosis compared to those who continue the medication. This trial looks at hospitalizations, infections, and overall health outcomes.

Liver Cirrhosis1-2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesGastroenterologyInternal Medicine

Oocyte Cryopreservation: Random Start Ovarian Stimulation

We are comparing a new method of ovarian stimulation with a traditional approach for women planning to freeze their eggs. This study aims to determine if the new method is equally effective.

Prevention of Female Infertility≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Tranexamic Acid for Reducing Blood Transfusions in Abdominal Surgery

We are studying whether Tranexamic Acid can lower blood loss and the need for blood transfusions during major abdominal surgeries. This trial also examines safety and recovery outcomes for patients.

Intraoperative Bleeding1-2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesHematologyOrthopedics and Traumatology

Non-Functioning Pituitary Adenomas: Cabergoline Treatment

We are studying the effects of cabergoline on non-functioning pituitary adenomas. This trial aims to see if this medication can improve treatment outcomes for patients.

Non-functioning Pituitary Adenoma>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteEndocrinologyOncology

Bone Health: Alendronate Discontinuation Study

We are investigating the effects of stopping alendronate on fracture risk in patients with osteoporosis. The study also looks at whether specific health factors can predict bone loss after discontinuation.

Osteoporosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementInternal MedicineOtolaryngology