Search Clinical Trials in the European Union

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201-220 of 240 trials

Chronic Kidney Disease: Vicadrostat and Empagliflozin Study

We are investigating whether starting vicadrostat with empagliflozin helps people with chronic kidney disease. The study compares two different ways of starting the medications to see which is more effective.

Chronic Kidney Disease≤3 monthsEfficacy phase (II)Investigational MedicinesCost ReimbursementPartially RemoteDiabetologyNephrology

Immune Thrombocytopenia: Pirtobrutinib Study

We are investigating a new medication, pirtobrutinib, for adults with immune thrombocytopenia. The study aims to assess its safety and effectiveness compared to a placebo.

Immune Thrombocytopenia≤3 monthsSafety phase (I)Efficacy phase (II)11-15 visitsStandard MedicinesCost ReimbursementPartially RemoteHematology

Turner Syndrome: Oral vs. Transdermal Estrogen

We are studying whether oral and transdermal estrogen treatments provide similar benefits for women with Turner Syndrome. This research may help tailor hormone therapy to individual needs.

Turner's Syndrome≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Antibiotic Levels in Pregnant Women with Twins

We are studying how antibiotics are processed in mothers of twins and their newborns. This research may help improve treatment safety and effectiveness for both mothers and babies.

Pregnancy≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases

Anticoagulation Strategies for ECMO Support

We are comparing three blood-thinning medications to see which is safer and more effective for patients on ECMO. This study aims to reduce blood clots and bleeding risks during treatment.

Respiratory Failure and Insufficiency≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Erosive Esophagitis: Linaprazan Glurate vs. Lansoprazole

We are studying whether linaprazan glurate can heal erosive esophagitis in patients with GERD better than lansoprazole. This trial aims to evaluate the effectiveness and safety of the new treatment.

Erosive Esophagitis≤3 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterology

Levosimendan for Faster Recovery from Ventilation

We are studying whether levosimendan can help critically ill patients wean off invasive ventilation more quickly. The trial also examines patient experiences and healthcare needs during recovery.

Difficulty Stopping Mechanical Ventilation≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyPulmonology

Dapansutrile Tablets for Acute Gout Flare

We are studying whether dapansutrile can reduce joint pain and other symptoms in people experiencing an acute gout flare. This trial compares the medication to a placebo to assess its effectiveness and safety.

Gout Flare≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesInternal MedicineRheumatology

Knee Osteoarthritis: Study of 4P004 Treatment

We are investigating whether the treatment 4P004 can reduce pain and improve function in people with knee synovitis and osteoarthritis. Participants will receive either the treatment or a placebo to assess its effectiveness and safety.

Knee Synovitis and Osteoarthritis≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteOrthopedics and TraumatologyRheumatology

Cannabinoids for Quality of Life in Cancer Patients

We are studying whether a cannabinoid solution can improve symptoms and overall well-being in patients with cancer. This trial compares its effects to a placebo to gather important data for future research.

Healthy Participants≤3 monthsEfficacy phase (II)Investigational MedicinesInternal MedicineOncology

Atrial Fibrillation Prevention: Landiolol Hydrochloride

We are studying whether Landiolol hydrochloride can help prevent atrial fibrillation in patients undergoing heart surgery. This trial looks at how often this condition occurs in the days following the surgery.

Normal Heart RhythmNormal Ejection FractionBeta-blocker Use≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyInternal Medicine

Worsening Heart Failure: COR-1167 Treatment Study

We are testing a new medication for people with worsening heart failure to see how it affects symptoms and heart health. The study will also check the safety and tolerability of this treatment.

Worsening Heart Failure≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementCardiologyInternal Medicine

Neurotrophic Keratopathy: RGN-259 Eye Drops

We are studying a new eye drop solution for people with Neurotrophic Keratopathy. The trial will compare its effects to a placebo to see if it improves eye health.

Neurotrophic Keratitis≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Esketamine for Schizophrenia Symptoms

We are studying whether esketamine can reduce depressive and negative symptoms in people with schizophrenia. The trial also looks at whether it causes any worsening of psychotic symptoms.

Negative and Depressive Symptoms in Schizophrenia and Schizoaffective Disorder≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesPsychiatry

Staphylococcus Aureus Bacteremia: Comparing Antibiotic Durations

We are studying whether 7 days of antibiotic treatment is as effective as 14 days for patients with uncomplicated Staphylococcus aureus bacteremia. This may help reduce antibiotic use and hospital stays.

Staphylococcus aureus Bacteremia≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Refractory Schizophrenia: NaBen® with Clozapine

We are studying whether NaBen®, a new medication, can help adults with refractory schizophrenia who still have symptoms despite treatment with clozapine. The trial will also assess the safety of this combination therapy.

Treatment-resistant Schizophrenia≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesCost ReimbursementPsychiatry

Glioblastoma Multiforme: Itraconazole with Radiotherapy and Temozolomide

We are studying whether adding Itraconazole to standard radiotherapy and temozolomide is safe for patients with newly diagnosed glioblastoma. Our goal is to find the best dose and understand its effects on survival and quality of life.

Glioblastoma≤3 monthsSafety phase (I)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Crohn's Disease in Children: Budesonide Treatment

We are studying a topical treatment with budesonide for children with Crohn's disease affecting the esophagus, stomach, or duodenum. The goal is to see if it helps reduce inflammation in these areas.

Crohn's Disease≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyPediatrics

Dry Eye Disease: PRGF Eye Drops for Glaucoma Patients

We are studying whether PRGF eye drops can help relieve dry eye symptoms in patients with glaucoma. The trial also looks at the safety of these eye drops for this condition.

GlaucomaDry Eye Disease≤3 monthsConfirmation phase (III)Monitoring phase (IV)Investigational MedicinesOphthalmology

Bowel Dysfunction After Rectal Cancer Surgery: Irrigation vs. Suppositories

We are comparing transanal irrigation and glycerol suppositories to see which treatment better improves bowel function and quality of life for patients after rectal cancer surgery.

Low Anterior Resection Syndrome≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine