Search Clinical Trials in the European Union

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261-280 of 552 trials

Alzheimer's Disease: Understanding Tau Spread and Language Function

We are studying how tau protein spreads in the brain during different stages of Alzheimer's disease and its impact on language abilities. This research may help us understand cognitive changes in patients.

Early Alzheimer's Disease>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesNeurologyPsychiatry

Cirrhosis: Carvedilol for Prevention

We are studying whether low-dose carvedilol can help prevent complications or death in patients with asymptomatic cirrhosis. This trial focuses on individuals with specific liver conditions to see if the medication is effective and safe.

Alcoholic Cirrhosis>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementHepatologyInternal Medicine

Bronchiectasis: 7% Hypertonic Saline Inhalation

We are studying whether inhaling a 7% hypertonic saline solution before physiotherapy helps patients with bronchiectasis clear mucus more effectively. We’ll also look at its impact on cough, quality of life, and any side effects.

Bronchiectasis1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboInvestigational MedicinesInternal MedicinePulmonology

Stage III Lung Cancer: Surgery and Durvalumab Study

We are exploring whether surgery is safe for patients with initially unresectable stage III lung cancer after high-dose treatment. We also want to see if they can benefit from a follow-up therapy called durvalumab.

Stage III Non-Small Cell Lung CancerMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Enterococcus faecalis Endocarditis: Continuous Infusion Antibiotics Study

We are studying whether continuous infusion of ampicillin and ceftriaxone is as effective as standard treatment for patients with Enterococcus faecalis infective endocarditis. This may help improve treatment outcomes and reduce complications.

Enterococcal Endocarditis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious Diseases

Semaglutide for Mood Improvement in Depression

We are studying if the medication semaglutide can help improve mood in people with major depressive disorder who are also overweight or obese. The trial will measure changes in depressive symptoms and overall well-being.

Unipolar DepressionObesity and Overweight6-12 monthsConfirmation phase (III)Monitoring phase (IV)Investigational MedicinesCost ReimbursementPsychiatry

Heart Attack Treatment: Timing of Medications

We are studying how the timing of beta blockers, ACE inhibitors, and SGLT2 inhibitors affects heart function in people who have had a heart attack. This may help us understand the best way to use these medications for better recovery.

Heart Attack>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Fecal Microbiota Transplantation for Crohn’s Disease After Anti-TNF Withdrawal

We are studying whether fecal microbiota transplantation can help maintain remission in Crohn’s disease patients after stopping anti-TNF treatment. This trial compares FMT to a sham procedure to assess its effectiveness in preventing relapse and improving gut health.

Crohn's DiseaseConfirmation phase (III)Monitoring phase (IV)6-10 visitsInvestigational MedicinesGastroenterologyInternal Medicine

COPD Exacerbation: New Diagnostic Strategy

We are testing a new method using advanced diagnostics to see if it can help reduce antibiotic use during severe COPD flare-ups. This study compares this approach to standard treatment to evaluate its effectiveness and safety.

Severe COPD with Ventilation Support>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPulmonology

Postoperative Pain Relief After Hip Surgery: Intrathecal Morphine Study

We are testing whether intrathecal morphine, with or without a specific nerve block, can improve pain relief after total hip arthroplasty. This study aims to find the best way to manage pain during recovery.

Total Hip Replacement Surgery1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurologyOrthopedics and Traumatology

Pneumonia in Preschool Children: Amoxicillin Study

We are investigating whether amoxicillin helps preschool children with pneumonia compared to a placebo. The study also looks at how the antibiotic affects airway bacteria and other related factors.

Community Acquired Pneumonia>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteInfectious DiseasesPulmonology

Apixaban in Short Bowel Syndrome Patients

We are studying how the blood levels of apixaban differ in patients with short bowel syndrome who require long-term IV nutrition. This research may help improve treatment strategies for these patients.

Short Bowel Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Haemophilia A: Efanesoctocog Alfa Treatment Study

We are investigating how efanesoctocog alfa affects joint health in patients with haemophilia A. The study aims to understand improvements in joint swelling and overall health during treatment.

Haemophilia A1-2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteHematologyOrthopedics and Traumatology

Sleeping through Menopause: Hormone Therapy and Online Sleep Support

We are studying whether hormone therapy and a guided online sleep program can help improve sleep and mood in perimenopausal women. This trial aims to enhance mental health and overall well-being during this transition.

InsomniaClimacteric Symptoms3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsPsychiatry

Neurocritical Patients: Inhalation vs. Intravenous Sedation

We are studying whether inhalation sedation with isoflurane is more effective and safer than conventional intravenous sedation for patients in critical neurological care. This trial will help us understand the best sedation methods for these patients.

Pain ReliefMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Irritable Bowel Syndrome: Symbioflor®2 Treatment

We are studying an oral treatment with living bacteria for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to see if it helps reduce symptoms compared to a placebo.

Irritable Bowel Syndrome6-12 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementGastroenterology

Brain Surgery Pain Management: Nerve Block Comparison

We are comparing two types of nerve blocks to see which one helps reduce pain and improve recovery for patients undergoing brain surgery. This study aims to find the best option for managing discomfort during the procedure.

Patients Undergoing Craniotomy for Supratentorial Mass>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Kidney Health: SGLT2 Inhibitor for Prediabetes

We are studying whether adding a new medication to lifestyle changes can help improve kidney function in people with prediabetes. This trial will help us understand its potential benefits for kidney health.

Early Stage Chronic Kidney Disease6-12 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesEndocrinologyNephrology

Fluid Overload in ICU: Furosemide Treatment

We are studying whether a diuretic called furosemide helps critically ill patients with fluid overload recover better than a placebo. The focus is on increasing the number of days alive and out of the hospital after 90 days.

Fluid Overload>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteCardiologyInternal MedicinePulmonology

Distal Radius Fracture: Brachial Plexus Nerve Block

We are studying whether an ultrasound-guided nerve block helps adults with distal radius fractures manage pain better than standard treatment during closed reduction. This trial will assess both the benefits and potential risks.

Distal Radius Fracture>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOrthopedics and Traumatology