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2821-2840 of 3,900 trials

Diffuse Large B-Cell Lymphoma: Zilovertamab Vedotin with R-CHP

We are studying a new treatment combining zilovertamab vedotin with standard therapy for people with diffuse large B-cell lymphoma. The goal is to see if this combination works better than another treatment option.

Diffuse Large B-Cell Lymphoma>2 yearsEfficacy phase (II)Investigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Emicizumab Dosing in Congenital Hemophilia A Patients

We are studying whether personalized dosing of emicizumab can effectively prevent bleeding in patients with congenital hemophilia A compared to standard dosing. This trial also examines the impact on quality of life and treatment costs.

Hemophilia A1-2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementHematology

HPV 16: FluBHPVE6E7 Vaccine Study

We are testing different doses of a new vaccine for women infected with HPV 16. The goal is to see if it helps improve their condition compared to a placebo.

Human Papilloma Virus Infection>2 yearsSafety phase (I)Gynecology and ObstetricsInfectious Diseases

Head and Neck Cancer: INBRX-106 with Pembrolizumab

We are studying whether adding INBRX-106 to pembrolizumab helps patients with recurrent or metastatic head and neck cancer. This trial focuses on effectiveness, safety, and quality of life for those with high PD-L1 expression.

Head and Neck Squamous Cell CarcinomaEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementOncology

Epiflux: Investigating a New Treatment

We are exploring a new treatment called Epiflux for patients with a specific health condition. Our goal is to understand its effects and potential benefits compared to existing options.

Focal Epilepsy>2 yearsEfficacy phase (II)Neurology

Gout Treatment: Immediate vs. Delayed Febuxostat

We are studying whether starting febuxostat right after a gout attack helps reduce the number of gout days compared to starting it six weeks later. This trial is for individuals experiencing acute gout attacks.

Gout>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology

Neuroblastoma: 177Lu-DOTATATE Therapy for Children

We are evaluating a new radioactive treatment for children with refractory or recurrent neuroblastoma. The study aims to find the safest dose and assess how well the treatment works.

Recurrent or Refractory Neuroblastoma≤3 monthsSafety phase (I)No PlaceboInvestigational MedicinesOncologyPediatrics

Juvenile Idiopathic Arthritis: Biosimilar vs. Original Medications

We are studying whether switching between biosimilar and original anti-TNF medications helps children with Juvenile Idiopathic Arthritis maintain disease control. The trial will evaluate safety, effectiveness, and the occurrence of side effects.

Juvenile Idiopathic Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesRheumatology

Ischemic Stroke: DOAC Intravenous Thrombolysis Trial

We are studying whether intravenous thrombolysis is more effective than standard care for patients with ischemic stroke who have recently taken direct oral anticoagulants. This research aims to improve recovery outcomes for these patients.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicineNeurology

Multiple Sclerosis: Immune Cell Therapy

We are testing a new treatment using the patient's own immune cells for individuals with early signs of multiple sclerosis. The goal is to assess its safety and feasibility.

Multiple SclerosisSafety phase (I)Neurology

CRD-4730 for Catecholaminergic Polymorphic Ventricular Tachycardia

We are studying a new medication, CRD-4730, to see if it is safe and tolerable for people with CPVT. The trial will also assess its effects on heart rhythm during exercise.

Catecholaminergic Polymorphic Ventricular TachycardiaEfficacy phase (II)Investigational MedicinesPartially RemoteCardiologyHematologyInternal Medicine

Kidney Transplant: Belatacept vs. Anticalcineurins

We are studying whether switching from anticalcineurins to Belatacept improves blood vessel function and reduces arterial stiffness in kidney transplant patients. This may help enhance overall cardiovascular health.

Kidney Transplant>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementNephrology

Hydroxychloroquine for Recurrent Pregnancy Loss

We are studying whether Hydroxychloroquine can help women with recurrent pregnancy loss achieve a live birth. The trial also examines pregnancy outcomes and potential complications compared to a placebo.

Recurrent Pregnancy Loss6-12 monthsEfficacy phase (II)Standard MedicinesGynecology and Obstetrics

Metastatic Colorectal Cancer: FLIRT Treatment Study

We are testing a combination of chemotherapy and targeted therapy for patients with a specific type of metastatic colorectal cancer. This study aims to see if this new approach improves treatment outcomes.

Metastatic Colorectal Cancer>2 yearsSafety phase (I)Efficacy phase (II)GastroenterologyOncology

Shoulder Surgery: Benzoyl Peroxide Treatment

We are studying whether applying a 5% benzoyl peroxide gel to the skin before shoulder surgery can reduce harmful bacteria. This may help lower the risk of infections in male patients undergoing the procedure.

Cutibacterium acnes Infection in Shoulder Arthroplasty>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesDermatologyInfectious DiseasesOrthopedics and Traumatology

IVF Success: Exercise and Mediterranean Diet vs. Aspirin

We are studying whether exercise and a Mediterranean diet can improve live birth rates compared to aspirin for women undergoing in vitro fertilization. This research aims to find better ways to support fertility.

Women's Infertility>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesPartially RemoteCardiologyGynecology and Obstetrics

Mantle Cell Lymphoma: Sonrotoclax Plus Zanubrutinib

We are investigating whether the combination of sonrotoclax and zanubrutinib is more effective than a placebo with zanubrutinib for adults with relapsed or refractory mantle cell lymphoma. The study will also look at safety and how patients feel during treatment.

Relapsed or Refractory Mantle Cell LymphomaConfirmation phase (III)Investigational MedicinesOncology

Meningococcal Vaccine: Immune Response Study in Transgender and Cisgender Adults

We are investigating how healthy transgender and cisgender individuals aged 18 to 50 respond to the meningococcal serogroup B vaccine. This study aims to understand potential differences in immune responses between these groups.

Healthy Volunteers6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementInfectious DiseasesInternal Medicine

CAIX-Positive Cancer: 68Ga-OncoCAIX Imaging Agent

We are evaluating the safety of a new imaging agent for patients with CAIX-positive cancer. This study aims to ensure it is safe for use in future treatments.

Clear Cell Renal Cell CarcinomaSafety phase (I)Oncology

Bone Health: AGA2118 for Postmenopausal Women

We are studying whether AGA2118 can improve bone density in postmenopausal women with low bone mass. The trial compares its effects to a placebo over 12 months.

Postmenopausal OsteoporosisEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementEndocrinologyOrthopedics and TraumatologyRheumatology