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3521-3540 of 3,900 trials

SDL-M1 Nanoparticles: Safety Study

We are investigating the safety and tolerability of SDL-M1 nanoparticles in healthy volunteers. This study aims to gather important information before testing in patients.

Intrahepatic CholestasisSafety phase (I)Hepatology

Chronic Lymphocytic Leukemia: BGB-16673 Treatment Study

We are studying a new treatment called BGB-16673 for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma who have previously used other therapies. The goal is to see if it works better than current treatment options.

Chronic Lymphocytic Leukemia and Small Cell Lymphocytic Lymphoma>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesHematologyOncology

Vitamin D3 for Healing After Wisdom Tooth Removal

We are studying whether high doses of vitamin D3 can improve soft tissue healing after wisdom tooth extraction. We’ll also look at how it affects inflammation during recovery.

Vitamin D Insufficiency Related to Tooth Extraction1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngologyPediatrics

BCG Vaccine for Radiologically Isolated Syndrome (RIS)

We are studying whether the BCG vaccine can help reduce new brain lesions in people diagnosed with Radiologically Isolated Syndrome. The trial also looks at the safety of the vaccine and other brain changes over time.

Radiologically Isolated Syndrome>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesNeurology

Ulcerative Colitis and Crohn’s Disease: Long-term Study of Zasocitinib

We are investigating the long-term safety and effectiveness of oral zasocitinib in adults with moderately to severely active ulcerative colitis and Crohn’s disease. This study is for those who have responded to treatment in previous trials.

Ulcerative ColitisCrohn's Disease>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

SGLT-2 Inhibitors for Elderly Patients with Type 2 Diabetes

We are comparing different SGLT-2 inhibitors to see which helps elderly patients manage their blood sugar levels safely. The study looks at effectiveness and potential side effects over time.

Type 2 DiabetesMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesDiabetologyEndocrinology

Knee Osteoarthritis: Study of 4P004 Treatment

We are investigating whether the treatment 4P004 can reduce pain and improve function in people with knee synovitis and osteoarthritis. Participants will receive either the treatment or a placebo to assess its effectiveness and safety.

Knee Synovitis and Osteoarthritis≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteOrthopedics and TraumatologyRheumatology

Cannabinoids for Quality of Life in Cancer Patients

We are studying whether a cannabinoid solution can improve symptoms and overall well-being in patients with cancer. This trial compares its effects to a placebo to gather important data for future research.

Healthy Participants≤3 monthsEfficacy phase (II)Investigational MedicinesInternal MedicineOncology

Virus-Specific T-Cell Therapy for Resistant Viral Infections Post-Stem Cell Transplant

We are studying the safety of using specially selected T-cells to treat young patients with viral infections like Adenovirus and Cytomegalovirus after a stem cell transplant. The trial also aims to see how well this treatment controls symptoms related to these infections.

Graft Infection1-2 yearsSafety phase (I)No PlaceboHematologyInfectious Diseases

Narcolepsy and Idiopathic Hypersomnia: ORX750 Study

We are testing a new medication, ORX750, to see if it is safe and well-tolerated in people with narcolepsy and idiopathic hypersomnia. This study will help us understand how the drug works in the body.

Narcolepsy with CataplexyIdiopathic Hypersomnia3-6 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

High Blood Pressure: Metyrapone for Adrenal Tumors

We are studying if adding Metyrapone helps patients with high blood pressure and adrenal tumors manage their condition better. This trial aims to improve blood pressure control in those with subclinical Cushing's syndrome.

Adrenal Incidentalomas and Mild Cushing’s Syndrome>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCardiologyEndocrinology

Bladder Cancer: New Treatment Combination Study

We are investigating a new treatment combining chemotherapy and immunotherapy with radiotherapy for patients with non-metastatic muscle invasive bladder cancer. The goal is to see if this approach improves survival and quality of life after surgery.

Non-Metastatic Muscle Invasive Bladder Cancer1-2 yearsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesOncologyUrology

Pancreatic Cancer: Nabpaclitaxel Chemotherapy Study

We are studying a new combination of chemotherapy treatments for patients with pancreatic cancer that has spread to the abdominal lining. The goal is to see if this approach can help shrink tumors and improve survival.

Pancreatic Cancer with Peritoneal MetastasesEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Myasthenia Gravis: Rituximab Treatment Study

We are studying whether rituximab can help improve symptoms and quality of life for patients with generalized AChR-antibody positive Myasthenia Gravis. The trial will also assess its safety and impact on other treatments.

Generalized Myasthenia Gravis6-12 monthsConfirmation phase (III)Standard MedicinesNeurologyRheumatology

Cardiac Arrest: Landiolol Treatment Study

We are testing whether adding landiolol can help patients who have had a cardiac arrest regain a stable heartbeat faster. This study will also look at overall survival and safety outcomes.

Cardiac Arrest and Ventricular Fibrillation6-12 monthsEfficacy phase (II)6-10 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Atrial Fibrillation Prevention: Landiolol Hydrochloride

We are studying whether Landiolol hydrochloride can help prevent atrial fibrillation in patients undergoing heart surgery. This trial looks at how often this condition occurs in the days following the surgery.

Normal Heart RhythmNormal Ejection FractionBeta-blocker Use≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyInternal Medicine

Worsening Heart Failure: COR-1167 Treatment Study

We are testing a new medication for people with worsening heart failure to see how it affects symptoms and heart health. The study will also check the safety and tolerability of this treatment.

Worsening Heart Failure≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementCardiologyInternal Medicine

Riluzole for Spinocerebellar Ataxia Type 7

We are studying whether Riluzole can help patients with Spinocerebellar Ataxia type 7 maintain their stability in symptoms and visual function. This trial will also assess the safety and tolerability of the medication.

Spinocerebellar Ataxia Type 7 (SCA7)1-2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesInternal MedicineNeurology

Neurotrophic Keratopathy: RGN-259 Eye Drops

We are studying a new eye drop solution for people with Neurotrophic Keratopathy. The trial will compare its effects to a placebo to see if it improves eye health.

Neurotrophic Keratitis≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Chronic Graft-Versus-Host Disease: Axatilimab Treatment Study

We are comparing a new treatment called axatilimab to the best available therapy for patients with chronic graft-versus-host disease who have not responded to previous treatments. The goal is to see if axatilimab is more effective and safer.

Chronic Graft-Versus-Host Disease>2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology