Search Clinical Trials in the European Union

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361-380 of 552 trials

Juvenile Idiopathic Arthritis: Early Drug Withdrawal Study

We are exploring whether stopping medication early is safe and effective for children with juvenile idiopathic arthritis in remission. This study also aims to identify new biomarkers that may help predict flare-ups after treatment withdrawal.

Juvenile Idiopathic Arthritis3-6 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPediatricsRheumatology

Gout Treatment: Prednisolone vs. Colchicine

We are comparing two medications for treating acute gout attacks to see which one provides better pain relief and improves joint function. This study aims to help patients find more effective treatment options.

Gout>2 yearsMonitoring phase (IV)Standard MedicinesRheumatology

Inflammatory Bowel Disease: Vedolizumab Dose Reduction Study

We are studying whether patients with inflammatory bowel disease can safely lower their dose of vedolizumab. This trial will help us understand the effects on health, costs, and quality of life.

Inflammatory Bowel Disease1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Prostate Cancer: Enzalutamide Study

We are investigating how Enzalutamide affects molecular changes in men with localized prostate cancer before and after surgery. This study may help us understand its impact on cell growth and gene activity.

Prostate Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Post-Surgery Pain Management: Ropivacaine Concentration Study

We are investigating whether different concentrations of ropivacaine can help reduce pain after volar plate surgery. This study aims to see if higher doses lead to less rebound pain and better overall pain control.

Radius Fracture>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOrthopedics and TraumatologyOtolaryngologyPsychiatry

Kidney Health After Liver Transplant: Human Albumin Study

We are investigating whether higher doses of human albumin can help reduce kidney problems after liver transplantation. This study looks at various recovery aspects, including hospital stay and potential complications.

Liver Transplantation≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesHepatologyNephrology

Severe Asthma: Predicting Response to Benralizumab

We are studying whether early blood tests can predict how well severe asthma patients respond to Benralizumab treatment. This may help identify those who are likely to experience fewer asthma attacks.

Severe Asthma>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteAllergologyPulmonology

Pemphigus: Personalized Treatment Strategy vs. Standard Care

We are studying whether a personalized treatment plan based on specific blood markers can reduce relapse rates in pemphigus patients compared to standard treatment with rituximab and corticosteroids.

Pemphigus Diseases>2 yearsMonitoring phase (IV)>20 visitsNo PlaceboStandard MedicinesDermatologyRheumatology

Acute Hyperkalemia: Comparing Treatments

We are studying whether insulin/dextrose infusion, nebulized salbutamol, or their combination is more effective in lowering high potassium levels in emergency patients. This research aims to find the best first-line treatment for acute hyperkalemia.

High Potassium Levels>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Irritable Bowel Syndrome: MYRRHINIL-INTEST®

We are investigating whether MYRRHINIL-INTEST® is effective and safe for people with diarrhoea-dominant and mixed-type irritable bowel syndrome. This study compares it to a placebo to see how well it works.

Diarrhea Predominant Irritable Bowel Syndrome≤3 monthsMonitoring phase (IV)≤5 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Short Course Antibiotics for Gram-Negative Bacteremia

We are studying whether a 5-day antibiotic treatment is as effective and safe as longer treatments for hospitalized adults with Gram-negative bacteremia from urinary tract infections.

Gram-negative Bacteremia3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Emergency Tracheal Intubation: New Optimization Strategy

We are studying a new method for emergency tracheal intubation to see if it reduces complications in adult patients. This approach combines medication and ventilation techniques to improve patient safety during emergencies.

Respiratory Distress>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard Medicines

Avapritinib: Continued Access for Previous Study Participants

We are offering ongoing access to avapritinib for adults who benefited from it in a prior study. This trial also aims to evaluate the long-term safety of the treatment.

Systemic Mastocytosis6-12 monthsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Alzheimer's Disease: Donepezil vs. Non-Drug Treatment

We are studying whether daily donepezil can improve thinking skills in people with Alzheimer's compared to usual non-drug care. We will also look at its effects on quality of life and other clinical measures.

Alzheimer's Disease6-12 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesNeurology

Kidney Transplant: Rituximab for EBV Prevention

We are studying whether early treatment with Rituximab can help prevent EBV infections and related complications in kidney transplant recipients who are EBV negative. This research aims to improve outcomes for patients receiving organs from EBV positive donors.

Epstein-Barr Virus in Kidney Transplant Patients>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesHematologyInfectious DiseasesNephrology

Intravenous Iron for Mobility After Hip Fracture Surgery

We are studying whether a single dose of intravenous iron helps elderly patients recover mobility after hip fracture surgery. The trial will also assess its effects on anemia, fatigue, and quality of life.

Hip Fracture3-6 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesInternal MedicineOrthopedics and Traumatology

Rabies Vaccine: Pain and Usability Study for Kids

We are exploring how different injection methods affect pain and anxiety in children aged 4 to 14 receiving a rabies vaccine. Parents will also share their observations about their child's experience.

Rabies Pre-Exposure Prophylaxis3-6 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementInfectious DiseasesPediatrics

Short Bowel Syndrome: Antibiotic Absorption Study

We are investigating how well certain antibiotics are absorbed in people with short bowel syndrome. This study aims to understand if these medications work effectively in this group.

Short Bowel Syndrome>2 yearsMonitoring phase (IV)Gastroenterology

Desmoid Tumors: Nirogacestat Study for Women

We are studying how Nirogacestat affects ovarian function in adult premenopausal women with desmoid tumors. The trial aims to understand any ovarian toxicity and the overall safety of the treatment.

Desmoid Tumors (Aggressive Fibromatosis)1-2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsOncology

HPV Vaccine Study for Women with HPV 16/18

We are studying how the 9vHPV vaccine affects the infectivity of HPV in women who are positive for HPV types 16 and/or 18. The goal is to see if vaccination reduces the virus in cervical, anal, urine, vulvar, and oral samples.

Human Papillomavirus Infection>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases