Search Clinical Trials in the European Union

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441-460 of 552 trials

IVF/ICSI: Optimizing Recombinant FSH Dosing

We are studying the best dose of recombinant FSH for patients undergoing IVF/ICSI to improve hormone levels and pregnancy outcomes. This research may help enhance fertility treatment success.

Female Subfertility1-2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

TOASST Study: Comparing Steroid Withdrawal Methods

We are studying whether stopping glucocorticoids suddenly is as safe as tapering them for patients with inflammatory disorders. This research may help improve treatment strategies and patient outcomes.

Inflammatory or Autoimmune Disorders>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineRheumatology

Statin Therapy for Frail Older Adults After Stroke

We are studying whether starting statin medication helps frail individuals aged 70 and older who have had a recent stroke or transient ischemic attack. The goal is to see if it improves heart health and quality of life.

Ischemic Stroke and Transient Ischemic Attack>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesPartially RemoteCardiologyInternal MedicineNeurology

COVID-19 Vaccine Immunology Study in Finland

We are studying how different COVID-19 vaccines affect immune responses in various groups. This research may help us understand the need for boosters and how well vaccines work against different virus variants.

COVID-196-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInfectious DiseasesInternal Medicine

Pancreas and Kidney Transplant: Sirolimus vs. Mycophenolate Mofetil

We are comparing two medications to see which one may reduce the risk of hernias after simultaneous pancreas and kidney transplants in people with type 1 diabetes. We also want to understand their effects on diabetes complications.

End-stage Kidney Disease in Type 1 DiabetesTransplantation ComplicationsSimultaneous Pancreas and Kidney Transplantation>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesGastroenterologyInternal MedicineNephrologyOncologyUrology

Heart Function in Cancer Patients: Nivolumab and Pembrolizumab

We are studying how immunotherapy treatments affect heart function in patients with cancer. This includes monitoring changes in heart performance and rhythm during treatment.

Cancer3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyOncology

Heart Inflammation: Immunosuppressive Treatment Study

We are studying whether a combination of prednisone and azathioprine can improve heart function in patients with inflammatory heart disease. This trial compares the treatment to a placebo to see if it offers any benefits.

Myocarditis>2 yearsMonitoring phase (IV)11-15 visitsStandard MedicinesCardiologyInternal Medicine

Infantile Spasms: Vigabatrin for High-Risk Children

We are studying whether vigabatrin can prevent infantile spasms in children under 1 year old who are at high risk due to conditions like tuberous sclerosis. This research aims to improve outcomes for these vulnerable infants.

High-Risk Infantile Spasm Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurology

Preventing Infections After Hysterectomy: Azithromycin vs. Cefuroxime

We are studying whether a combination of azithromycin and cefuroxime can better prevent infections after hysterectomy compared to cefuroxime alone. This research aims to improve antibiotic use in surgical settings.

Undergoing Hysterectomy>2 yearsMonitoring phase (IV)Investigational MedicinesGynecology and ObstetricsInfectious Diseases

Post-Surgery Pain Management: Comparing Two Techniques

We are studying the effectiveness of two different nerve block methods for pain relief after laparoscopic colon surgery. Our goal is to see if these methods work better than traditional oral pain medications.

Colon Surgery for Cancer or Diverticulosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngology

Severe Asthma: Tezepelumab Treatment

We are exploring how Tezepelumab may improve airway barrier function in patients with severe asthma, including those with chronic rhinosinusitis. This study looks at the effects of the treatment on the airways' response to harmful substances.

Severe Asthma with Chronic Rhinosinusitis and Nasal PolypsSevere Asthma without Chronic Rhinosinusitis>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesAllergologyOtolaryngologyPulmonology

Neovascular Age-Related Macular Degeneration: Faricimab Injections

We are studying the safety and long-term effectiveness of faricimab injections for people with neovascular age-related macular degeneration. The goal is to see if it improves vision and how well it works over time.

Neovascular Age-Related Macular Degeneration>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOphthalmology

Severe Asthma: Dupilumab Treatment Study

We are investigating how Dupilumab affects mucus buildup and immune responses in patients with severe asthma. This study aims to improve understanding of asthma management and treatment options.

Severe Asthma>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteAllergologyPulmonology

Lung Surgery: Oxygen Delivery Techniques

We are comparing three methods of oxygen administration during lung surgery to see how they affect recovery and complications. This study aims to find the best approach for improving patient outcomes after surgery.

Lung Resection Surgery>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPulmonology

Difficult-to-Treat Hypertension: OPTIMAL-HT Study

We are exploring whether a new combination of medications can help people with uncontrolled high blood pressure achieve better control. This study will compare different treatment strategies to find the most effective approach.

High Blood Pressure (Hypertension)OverpressureConfirmation phase (III)Monitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

Severe Spasticity: Botulinum Toxin Type A Treatment

We are studying the effects and safety of a personalized dose of botulinum toxin type A for individuals with severe spasticity. This trial aims to see how well it works for managing symptoms in the upper and lower limbs.

Spasticity Due to Brain Damage1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurology

Labor Induction: Oxytocin vs. Prostaglandins

We are studying whether oxytocin is as safe as prostaglandins for inducing labor in women with an unfavorable cervix. This trial will help us understand the risks and benefits of both methods.

Labor Induction>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesGynecology and Obstetrics

Endoscopic Sleeve Gastroplasty: Impact of Proton Pump Inhibitors

We are studying how proton pump inhibitors affect the success of endoscopic sleeve gastroplasty in people seeking weight loss. We also want to learn about their effects on quality of life and metabolic health.

Obesity1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Tacrolimus Monotherapy for Elderly Kidney Transplant Recipients

We are studying whether using tacrolimus alone can reduce infection risks and improve quality of life for elderly patients after a kidney transplant. This trial compares it to the standard triple medication regimen.

Kidney Transplant Complications>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineNephrology

End-of-Life Care: Midazolam and Morphine Study

We are investigating how midazolam and morphine can help relieve pain and discomfort in elderly patients during their final days. This study aims to understand the best dosing strategies and any potential side effects.

Symptom Treatment in End-of-Life Care for Geriatric Patients1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine