Search Clinical Trials in the European Union

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481-500 of 552 trials

Breast MRI: Low-Dose Gadolinium Study

We are testing whether a lower dose of gadolinium in breast MRI can provide image quality similar to the standard dose. This may help reduce contrast exposure while maintaining diagnostic accuracy.

Breast Cancer1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOncologyOtolaryngology

Turner Syndrome: Oral vs. Transdermal Estrogen

We are studying whether oral and transdermal estrogen treatments provide similar benefits for women with Turner Syndrome. This research may help tailor hormone therapy to individual needs.

Turner's Syndrome≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Antibiotic Levels in Pregnant Women with Twins

We are studying how antibiotics are processed in mothers of twins and their newborns. This research may help improve treatment safety and effectiveness for both mothers and babies.

Pregnancy≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases

Ulcerative Rectal Colitis: Tofacitinib Response Study

We are researching what factors may predict how well patients with ulcerative rectal colitis respond to Tofacitinib therapy. This could help improve treatment strategies for better patient care.

Ulcerative Colitis>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Steroid Withdrawal in Systemic Lupus Erythematosus (SLE)

We are studying whether stopping glucocorticoids is as effective as continuing a low dose for patients with stable SLE. This research aims to understand the impact on disease activity and quality of life over three years.

Systemic Lupus Erythematosus>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Bloodstream Infections: PipEracillin Tazobactam vs. Meropenem

We are studying whether PipEracillin Tazobactam is as effective as Meropenem for treating bloodstream infections caused by certain resistant bacteria. This trial is for patients with infections from these specific bacteria.

Bacteremia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Ulcerative Colitis: MK-7240 Treatment Study

We are studying MK-7240 to see if it helps people with moderately to severely active ulcerative colitis achieve remission. The trial will also evaluate the safety and effectiveness of this new treatment compared to a placebo.

Ulcerative Colitis1-2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterology

Prostate Cancer Treatment: Docetaxel vs. Androgen Receptor-targeted Agents

We are studying whether docetaxel is more effective than abiraterone or enzalutamide for men with advanced prostate cancer and specific negative prognostic factors. This research aims to improve treatment outcomes and quality of life.

Metastatic Castration-Resistant Prostate CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Liraglutide: Effects on Digestion and Hunger

We are studying how liraglutide affects digestive activity and hunger in healthy volunteers. This research may help us understand its potential benefits for managing appetite.

Obesity1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesEndocrinologyGastroenterology

Acute Cholecystitis: Indocyanine Green in Surgery

We are testing whether indocyanine green can help reduce surgery time and improve safety during gallbladder removal in patients with acute cholecystitis. This study aims to enhance surgical outcomes and patient satisfaction.

Acute Cholecystitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

MOTHER Trial: Low-Dose Morphine for Cesarean Section Pain

We are studying whether adding a low dose of morphine to standard pain management helps reduce pain after a planned cesarean section. The trial also looks at the safety for both mothers and their newborns.

Planned Caesarean Section>2 yearsMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsOtolaryngology

Anticoagulation Strategies for ECMO Support

We are comparing three blood-thinning medications to see which is safer and more effective for patients on ECMO. This study aims to reduce blood clots and bleeding risks during treatment.

Respiratory Failure and Insufficiency≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Heart Procedure: Beta Blocker Study

We are investigating how beta blockers may impact patients undergoing transcatheter aortic valve replacement. This study aims to understand their effects on recovery and outcomes.

Aortic Stenosis>2 yearsMonitoring phase (IV)Cardiology

Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

Severe Acute Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Kidney Transplant: SGLT2 Inhibitor Study

We are investigating whether a new oral medication can improve kidney function in non-diabetic kidney transplant recipients. The study also looks at its safety and effects on overall health compared to a placebo.

Kidney Transplant1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesInternal MedicineNephrology

Rheumatoid Arthritis: Prednisolone Tapering Strategies

We are studying whether a quick reduction of low-dose Prednisolone is as effective as a slower taper for newly diagnosed rheumatoid arthritis patients. The goal is to see how these approaches affect pain, function, and overall health.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Levosimendan for Faster Recovery from Ventilation

We are studying whether levosimendan can help critically ill patients wean off invasive ventilation more quickly. The trial also examines patient experiences and healthcare needs during recovery.

Difficulty Stopping Mechanical Ventilation≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyPulmonology

Kidney Transplant: Mannitol vs. Normal Saline

We are studying whether mannitol can help improve kidney transplant outcomes by reducing delayed graft function and early rejections. This trial involves both kidney donors and recipients.

End-Stage Renal Disease>2 yearsMonitoring phase (IV)Standard MedicinesNephrologyUrology

Peyronie's Disease: FAPI-PET/CT and FDG-PET/CT Scans

We are investigating whether special imaging scans can detect inflammation and active tissue changes in men with acute Peyronie's Disease. This may help improve diagnosis and treatment options.

Peyronie's Disease6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementOtolaryngologyUrology

Multiple Sclerosis: Ozanimod Treatment Study

We are investigating how ozanimod affects inflammation in the brain and spinal cord for individuals with Multiple Sclerosis. This study aims to understand its potential benefits and any side effects.

Relapsing Multiple Sclerosis>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesNeurology