Search Clinical Trials in the European Union

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481-500 of 1,743 trials

Postoperative Pain Management After Cardiac Surgery: NSAIDs Study

We are investigating whether nonsteroidal anti-inflammatory drugs can help reduce pain after cardiac surgery. This study will also look at how these medications affect recovery and overall quality of life.

Postoperative Pain After Cardiac Surgery>2 yearsMonitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

AUTO1 Treatment for Pediatric Blood Cancers

We are studying the safety and early effectiveness of AUTO1 in children with relapsed or refractory B cell acute lymphoblastic leukemia and aggressive mature B cell non-Hodgkin lymphoma. This trial aims to see how well the treatment works and how it can be safely administered.

B-cell Acute Lymphoblastic LeukemiaAggressive Mature B-cell Non-Hodgkin Lymphoma>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesHematologyOncology

Advanced Melanoma: RO7276389 and Cobimetinib Study

We are evaluating a new treatment for patients with advanced solid tumors or melanoma that have a specific genetic mutation. This study looks at the safety and early effects of the treatment alone and in combination with another drug.

Metastatic Melanoma>2 yearsSafety phase (I)Oncology

Melanoma Treatment: Pembrolizumab with New Agents

We are studying the safety and effectiveness of pembrolizumab alone or with new investigational treatments for people with melanoma. This research aims to find better options for managing this type of skin cancer.

Melanoma>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Lung Cancer: V940 and Pembrolizumab Study

We are studying the effects of a new treatment combining V940 with pembrolizumab for patients with resectable stage II to IIIB lung cancer. The goal is to see if this combination improves disease-free survival compared to a placebo.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)16-20 visitsInvestigational MedicinesCost ReimbursementOncologyPulmonology

Plaque Psoriasis: Bimekizumab Study

We are exploring how bimekizumab affects gene expression in people with moderate to severe plaque psoriasis. The study also looks at the safety of this treatment for those with or without psoriatic arthritis.

Plaque PsoriasisPsoriatic Arthritis>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesDermatologyRheumatology

Tourette Disorder: Serotonin and Impulsivity Study

We are investigating how serotonin receptors relate to impulsivity in adults with Tourette's syndrome. This study may help us understand brain activity and behavior during treatment.

Tourette Syndrome>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyPsychiatry

Advanced Urothelial Carcinoma: MK-2870 with Enfortumab Vedotin

We are studying a new treatment combining MK-2870 with Enfortumab Vedotin and Pembrolizumab for patients with advanced bladder cancer. The goal is to assess safety and how well it works compared to existing options.

Bladder Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Advanced Non-Small Cell Lung Cancer: JNJ-86974680 Study

We are exploring a new treatment for advanced non-small cell lung cancer using JNJ-86974680 alone and with other therapies. The goal is to see how well it works in combination with cetrelimab and radiotherapy.

Advanced Non-Small Cell Lung Cancer>2 yearsSafety phase (I)OncologyPulmonology

Melanoma, NSCLC, and Cervical Cancer: ANV419 vs High-Dose IL-2

We are studying whether a new treatment (ANV419) is safer and improves outcomes compared to high-dose IL-2 for patients after tumor-infiltrating lymphocyte therapy. This trial also looks at quality of life and patient experiences.

Advanced Solid Tumors>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

IDOR-1134-2831 Vaccine: Healthy Participants Study

We are evaluating a new vaccine in healthy individuals to see how it is administered and its effects. This study aims to understand its safety and how the body responds to it.

Clostridium Difficile Infection>2 yearsSafety phase (I)Infectious Diseases

Chronic Lymphocytic Leukemia: New Triple Therapy Study

We are testing a new combination of medications for patients with high-risk chronic lymphocytic leukemia who haven't been treated before. The study aims to see if this new treatment can help keep the disease from progressing better than standard options.

High-Risk Hematological Patients>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyOncology

Preventing Diabetes After Kidney Transplant: GLP-1 Treatment Study

We are studying whether a new medication can help prevent diabetes in patients immediately after receiving a kidney transplant. This trial looks at various health effects and safety over time.

Post-Kidney Transplant Diabetes>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesDiabetologyNephrology

Ulcerative Colitis: Comparing Ustekinumab and Infliximab

We are studying whether a combination of two treatments helps people with moderate to severe ulcerative colitis achieve remission better than using each treatment alone.

Ulcerative Colitis>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Chronic Kidney Disease: Baxdrostat with Dapagliflozin

We are studying whether the combination of baxdrostat and dapagliflozin is more effective than dapagliflozin alone for adults with chronic kidney disease and high blood pressure. The trial will assess its impact on kidney health and heart-related risks.

Chronic Kidney DiseaseHypertension>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementCardiologyInternal MedicineNephrology

Repotrectinib for Advanced Cancers in Kids and Young Adults

We are studying a new treatment for children and young adults with advanced cancers that have specific genetic changes. The trial aims to evaluate how well it works and its safety.

Advanced Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncologyPediatrics

Advanced Cancer: JNJ-87704916 Tumor-Targeting Virus

We are testing a new virus that targets tumors in patients with advanced cancer. The goal is to see if it can effectively attack cancer cells when injected directly into the tumor.

Advanced Solid Tumors>2 yearsSafety phase (I)Oncology

Parkinson’s Disease vs. Multiple System Atrophy: Imaging Study

We are comparing two imaging methods to see which one better identifies Parkinson’s disease and multiple system atrophy. This may help improve diagnosis for patients with these conditions.

Parkinson's DiseaseAlzheimer's DiseaseMultiple Systems Atrophy - Parkinsonian Variant>2 yearsEfficacy phase (II)Confirmation phase (III)NeurologyOtolaryngology

Parkinson's Disease: AAV2-GDNF Treatment Study

We are studying a new therapy to see if it can improve motor symptoms in adults with moderate Parkinson's Disease. The trial also looks at safety and overall quality of life for participants.

Parkinson's Disease>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesNeurology

Teicoplanin for Infection Prevention in Pediatric AML

We are studying whether teicoplanin can help prevent serious infections in children newly diagnosed with acute myeloid leukemia. This trial will assess its safety and effectiveness during their treatment.

Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesOncology