Search Clinical Trials in the European Union

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521-540 of 552 trials

Cerebrospinal Fluid Disorders: MRI Contrast Agent Study

We are testing a new MRI contrast agent to assess cerebrospinal fluid flow in adults with CSF disorders. This may help improve diagnosis and treatment of central nervous system conditions.

Idiopathic Intracranial HypertensionIntracranial CystsPrimary or Secondary Brain Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurologyOtolaryngology

Botox for Hidradenitis Suppurativa Treatment

We are studying whether Botox can help reduce symptoms in patients with Hidradenitis Suppurativa. This trial will assess changes in skin condition and patient satisfaction over several months.

Hidradenitis SuppurativaMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesAllergologyDermatology

Infective Endocarditis: Oral vs. Parenteral Antibiotics

We are comparing oral antibiotics to outpatient parenteral antibiotics for treating infective endocarditis. The goal is to see if oral treatment is as effective and to assess patient satisfaction and costs.

Infective Endocarditis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious Diseases

Rheumatoid Arthritis: Lower Dose of Rituximab Study

We are evaluating whether a 200 mg dose of Rituximab every six months is as effective as the standard 1 g dose for managing rheumatoid arthritis. This study will help us understand its impact on disease activity and overall patient well-being.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementRheumatology

Bladder Cancer: EMDA-MMC Treatment Study

We are evaluating a new treatment using electric current to deliver mitomycin C for high-grade non-muscle invasive bladder cancer. This study compares its effectiveness and safety to the standard BCG therapy.

Non-Muscle Invasive Bladder Cancer>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesOncologyUrology

Bisphosphonate Treatment for Primary Hyperparathyroidism

We are studying whether bisphosphonate treatment before parathyroid surgery can improve bone, kidney, and heart health one year after the procedure. This trial compares the treatment to a placebo to see if there are any benefits.

Primary Hyperparathyroidism1-2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementEndocrinologyOrthopedics and Traumatology

Knee Replacement Surgery: Local Anesthetic Comparison

We are studying whether using 20 mL of local anesthetic instead of 10 mL during a nerve block can reduce opioid use and improve pain management after knee surgery.

Postoperative Pain After Knee Surgery≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

Recovery After Gallbladder Surgery: Esmolol vs. Sufentanil

We are comparing two medications to see which one helps patients recover more comfortably after laparoscopic gallbladder surgery. This study aims to improve patient comfort during the recovery process.

Laparoscopic Gallbladder Removal1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and TraumatologyOtolaryngology

Metastatic Colorectal Cancer: RAXO Trial

We are studying how metastatic colorectal cancer behaves and the effectiveness of different treatments in patients. This research aims to improve surgical options and overall patient outcomes.

Advanced Colorectal Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Breast Cancer: Typology-based Coaching with Ribociclib

We are studying whether personalized coaching and education can help patients with HR+ HER2- early breast cancer stay on their ribociclib treatment. This may improve their treatment experience and overall health outcomes.

Hormone Receptor Positive Breast CancerBreast Cancer>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncology

Scabies Treatment Comparison: Permethrin vs. Ivermectin

We are comparing the effectiveness of topical permethrin, oral ivermectin, and their combination for treating scabies. The goal is to find out which treatment works best and is safest for patients.

Scabies≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Heart Patients: Reduced Dose of Prasugrel

We are studying whether a lower dose of prasugrel is safe and effective for patients after heart procedures. The trial also looks at how well patients stick to this treatment compared to the usual approach.

Acute and Chronic Coronary SyndromeMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Onychomycosis: DexULac® Treatment Study

We are studying how well DexULac® works for treating nail fungal infections and its impact on patients' quality of life. This trial will help us understand the effectiveness and safety of this treatment over time.

Nail Fungus (Onychomycosis)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Kidney Transplant: Reduced Immunosuppression for Older Adults

We are studying whether a lower dose of immunosuppressive medication is as effective and safe as the standard dose for older adults after kidney transplantation. This may help improve their overall health and quality of life.

End-stage Renal Disease1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Dengue Vaccine Qdenga: Antibody Response Study

We are examining how the Qdenga vaccine affects antibody levels for other flavivirus infections in Swedish travelers. This study aims to see if vaccination leads to higher antibody levels that could interfere with diagnostic tests.

Healthy Participants3-6 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesAllergologyHematologyInfectious Diseases

Fluid Management in Critically Ill Adults: CRUSADERS Trial

We are studying whether reducing sodium and chloride in fluids helps critically ill adults have better health outcomes. This includes looking at effects on organ support needs and overall survival.

Healthy Participants>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNephrology

Inflammatory Rheumatic Diseases: JAK Inhibitor Dose Reduction Study

We are exploring if lowering the dose of JAK inhibitors is as effective as keeping the current dose for patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis in low disease activity. This study will also look at safety and how many patients can successfully reduce their medication.

Rheumatoid Arthritis, Psoriatic Arthritis, and Axial Spondyloarthritis1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineRheumatology

Tonsillectomy Pain Relief: Ropivacaine vs. Lidocaine

We are comparing two local anesthetics to see which one better reduces pain after tonsillectomy. This study aims to find the most effective option for managing postoperative discomfort.

Chronic Tonsillitis6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOtolaryngology

Choline Alfoscerate for Elderly with Subthreshold Depression

We are studying whether choline alfoscerate can help improve symptoms of subthreshold depression in elderly patients. The trial also looks at its effects on cognitive symptoms and apathy.

Under Threshold Depression in the Elderly1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPsychiatry

Atrial Fibrillation: Early Rhythm-Control Therapy for Stroke Prevention

We are studying if starting rhythm-control therapy early helps patients with atrial fibrillation after a stroke avoid further heart problems. This trial also examines the impact on quality of life and treatment costs.

Acute Ischemic Stroke and Atrial Fibrillation>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine