Search Clinical Trials in the European Union

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561-580 of 653 trials

STOP-LEUKEMIA: Metformin for Blood Disorders

We are investigating whether metformin can help prevent leukemia in patients with clonal cytopenia of undetermined significance and lower-risk myelodysplastic syndromes. This study will assess the safety of metformin and explore how it may affect disease progression.

Myelodysplastic Syndromes (MDS)Clonal Cytopenia of Undetermined Significance (CCUS)1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOncology

Cerebral Palsy: IncobotulinumtoxinA Treatment

We are studying the safety and effectiveness of IncobotulinumtoxinA for children with upper and lower limb spasticity due to cerebral palsy. This trial includes both new and previously treated patients to see how well the treatment works.

Muscle Spasticity1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesNeurologyPediatrics

Type 2 Diabetes: Retatrutide Study

We are evaluating how Retatrutide affects insulin secretion and sensitivity in adults with type 2 diabetes. This research may help improve diabetes management.

Diabetes Mellitus1-2 yearsSafety phase (I)EndocrinologyInternal Medicine

Neovascular Age-Related Macular Degeneration: AI-Assisted Treatment

We are exploring how artificial intelligence can help improve treatment for patients with active neovascular AMD. This study aims to make the treatment process easier for patients and healthcare providers.

Neovascular Age-Related Macular Degeneration1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOphthalmology

Allergic Rhinitis: New Immunotherapy Treatment

We are studying a new subcutaneous immunotherapy for patients with allergic rhinitis or rhinoconjunctivitis, with or without asthma. The goal is to evaluate its safety and effectiveness compared to a placebo.

Moderate to Severe Allergic Rhinitis with or without Asthma1-2 yearsEfficacy phase (II)Standard MedicinesAllergologyInternal Medicine

Diabetic Foot Syndrome: Stem Cell Treatment Study

We are investigating whether a new therapy using stem cells can help heal chronic wounds in people with diabetic foot syndrome. The study will compare this treatment to standard care to assess its safety and effectiveness.

Diabetic Foot Ulcer1-2 yearsEfficacy phase (II)Investigational MedicinesDiabetologyInternal Medicine

Breast MRI: Low-Dose Gadolinium Study

We are testing whether a lower dose of gadolinium in breast MRI can provide image quality similar to the standard dose. This may help reduce contrast exposure while maintaining diagnostic accuracy.

Breast Cancer1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOncologyOtolaryngology

Bloodstream Infections: PipEracillin Tazobactam vs. Meropenem

We are studying whether PipEracillin Tazobactam is as effective as Meropenem for treating bloodstream infections caused by certain resistant bacteria. This trial is for patients with infections from these specific bacteria.

Bacteremia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Ulcerative Colitis: MK-7240 Treatment Study

We are studying MK-7240 to see if it helps people with moderately to severely active ulcerative colitis achieve remission. The trial will also evaluate the safety and effectiveness of this new treatment compared to a placebo.

Ulcerative Colitis1-2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementGastroenterology

Liraglutide: Effects on Digestion and Hunger

We are studying how liraglutide affects digestive activity and hunger in healthy volunteers. This research may help us understand its potential benefits for managing appetite.

Obesity1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesEndocrinologyGastroenterology

Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

Cholangiocarcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Kidney Transplant: SGLT2 Inhibitor Study

We are investigating whether a new oral medication can improve kidney function in non-diabetic kidney transplant recipients. The study also looks at its safety and effects on overall health compared to a placebo.

Kidney Transplant1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesInternal MedicineNephrology

Durvalumab for Non-Surgical Non-Small Cell Lung Cancer

We are studying the safety and effectiveness of the immunotherapy durvalumab followed by radiation in patients with early stage or locally advanced non-small cell lung cancer. This trial aims to find out if this treatment approach can help those who cannot have surgery.

Non-Small Cell Lung Cancer1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology

Insulin Eye Drops for Persistent Corneal Epithelial Defects

We are studying whether insulin eye drops can help heal persistent corneal defects better than standard treatments. This trial will also assess the safety of insulin drops and explore factors that may influence treatment success.

Persistent Corneal Epithelial Defect1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOphthalmology

V540C Vaccine Study in Healthy Adults

We are investigating the V540C vaccine to see how it works in healthy adults. This study aims to assess its safety and immune response.

Human Papilloma Virus Infection1-2 yearsSafety phase (I)Infectious DiseasesOncology

Cushing's Disease: Silycus® Treatment Study

We are studying the effects of Silycus® on lowering cortisol levels in patients with Cushing's disease. The trial will also evaluate how well patients tolerate the treatment and its impact on their symptoms.

Cushing's Disease1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesEndocrinology

HIV Treatment: Venetoclax Study

We are testing the safety of a medication called venetoclax in people living with HIV who are on antiretroviral therapy. The aim is to see if it can help reduce the size of the HIV reservoir in the body.

HIV-1 Disease1-2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyInfectious Diseases

Nintedanib for Nosebleeds in Hereditary Hemorrhagic Telangiectasia

We are studying whether nintedanib can help reduce the duration of nosebleeds in patients with hereditary hemorrhagic telangiectasia. The trial also examines its effects on quality of life and potential side effects.

Hereditary Hemorrhagic Telangiectasia1-2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesHematologyInternal Medicine

Vitamin D3 for Healing After Wisdom Tooth Removal

We are studying whether high doses of vitamin D3 can improve soft tissue healing after wisdom tooth extraction. We’ll also look at how it affects inflammation during recovery.

Vitamin D Insufficiency Related to Tooth Extraction1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngologyPediatrics

Virus-Specific T-Cell Therapy for Resistant Viral Infections Post-Stem Cell Transplant

We are studying the safety of using specially selected T-cells to treat young patients with viral infections like Adenovirus and Cytomegalovirus after a stem cell transplant. The trial also aims to see how well this treatment controls symptoms related to these infections.

Graft Infection1-2 yearsSafety phase (I)No PlaceboHematologyInfectious Diseases