Search Clinical Trials in the European Union

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641-660 of 3,900 trials

Trigeminal Neuralgia: Botox Treatment Study

We are exploring whether Botox can effectively reduce pain in patients with trigeminal neuralgia compared to a placebo. Additionally, we’re investigating if specific biomarkers can help predict treatment response.

Trigeminal Neuralgia3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesNeurology

Colorectal Liver Metastases: IP-001 Immuno-Adjuvant Study

We are exploring a new treatment to see if it improves outcomes for patients with colorectal liver metastases after microwave ablation or electroporation. The study will help us understand the best dose and immune response.

Colorectal Liver Metastases>2 yearsSafety phase (I)Efficacy phase (II)GastroenterologyHepatologyInternal MedicineOncology

Carotid Stenosis: Ficolin-2 and Inflammation Study

We are investigating how levels of ficolin-2 relate to inflammation in the carotid arteries and brain in patients who have had a stroke or transient ischemic attack. This research may help us understand the underlying causes of these conditions better.

Stroke or Transient Ischemic Attack (TIA)>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal MedicineNeurology

Hereditary Haemochromatosis: NNC0614-0001 Study

We are evaluating the effects of a new treatment in healthy adults and individuals with hereditary haemochromatosis type 1. This research aims to understand how the treatment works in these groups.

Hereditary Hemochromatosis>2 yearsSafety phase (I)HematologyInternal Medicine

Hypotension Treatment: Early Vasopressor Therapy

We are studying whether starting vasopressor therapy early helps hypotensive patients in the emergency department recover faster than standard fluid therapy. This may reduce the need for intensive care admission.

Low Blood Pressure (Hypotension)Shock>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicinePulmonology

COVID-19 Vaccine Booster Study: CD40.RBDv

We are testing a new bivalent COVID-19 vaccine to see if it safely boosts immunity in volunteers. This study will help us understand its effectiveness compared to existing vaccines.

COVID-19>2 yearsSafety phase (I)Infectious Diseases

Advanced Non-Small Cell Lung Cancer: THIO with Cemiplimab

We are studying the safety and effectiveness of a new treatment combining THIO and cemiplimab for people with advanced non-small cell lung cancer. This trial aims to find out if this combination works better than THIO alone for patients who have already been treated.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Focal Segmental Glomerulosclerosis: DMX-200 Treatment Study

We are studying the effects of DMX-200 on kidney function in patients with focal segmental glomerulosclerosis who are taking an angiotensin II receptor blocker. This trial will help us understand its safety and effectiveness compared to standard treatments.

Focal Segmental Glomerulosclerosis>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteNephrology

Chronic Lymphocytic Leukemia: Venetoclax and Obinutuzumab Study

We are assessing the effectiveness and safety of a combination treatment for adults with recurring chronic lymphocytic leukemia. This study aims to understand how well the treatment works and what side effects may occur.

Recurrent Chronic Lymphocytic Leukemia1-2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyOncology

Hepatocellular Carcinoma: Livmoniplimab and Budigalimab Study

We are studying a combination of two medications for people with advanced liver cancer who have not had prior treatment. The goal is to find the best dose and assess safety and effectiveness.

Metastatic Liver Cancer1-2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteHepatologyOncology

Alzheimer's Disease: Rotigotine and Rivastigmine Study

We are testing a combination of rotigotine and rivastigmine to see if it improves thinking skills and daily activities in people with mild to moderate Alzheimer's disease. This study compares the new treatment to rivastigmine with a placebo.

Mild to Moderate Alzheimer's Disease3-6 monthsConfirmation phase (III)6-10 visitsStandard MedicinesPartially RemoteNeurology

Advanced Solid Tumors: IPH5301 Treatment Study

We are exploring a new treatment called IPH5301, both alone and with chemotherapy and trastuzumab, for patients with advanced solid tumors. This study aims to understand how well it works and its safety in humans.

Advanced and Metastatic Cancer>2 yearsSafety phase (I)Oncology

Cell Therapy for Acute Kidney Injury After Heart Surgery

We are studying whether modified autologous leukocyte cells can help patients recover kidney function after developing acute kidney injury following cardiac surgery. The trial will also assess the safety of this new treatment.

Acute Kidney Injury6-12 monthsEfficacy phase (II)Investigational MedicinesCardiologyNephrology

Colorectal Liver Metastases: SGM-101 and Indocyanine Green Imaging

We are studying the use of two imaging agents during surgery for colorectal liver metastases to see if they help surgeons remove cancerous tissue more effectively. This trial aims to improve surgical accuracy and patient outcomes.

Liver Metastases1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesInternal MedicineOncology

Chemotherapy-Induced Peripheral Neuropathy: Capsaicin Patch vs. Duloxetine

We are studying whether a capsaicin patch can reduce nerve pain better than duloxetine in patients with chemotherapy-induced peripheral neuropathy. The trial also looks at safety and overall quality of life improvements.

Chemotherapy Induced Peripheral Neuropathy>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesNeurologyOncology

Triple-Negative Breast Cancer: Pembrolizumab and Chemotherapy Study

We are investigating whether adding pembrolizumab to chemotherapy improves outcomes for patients with early-stage triple-negative breast cancer based on their tumor-infiltrating lymphocyte levels. This study also looks at the safety and quality of life for participants.

Triple Negative Breast Cancer6-12 monthsEfficacy phase (II)Standard MedicinesOncology

Severe Brain Injury: Apomorphine Treatment Study

We are investigating whether apomorphine can help patients with disorders of consciousness. The study also aims to identify which patients may respond best to this treatment.

Severe Brain Injury and Disorder of Consciousness≤3 monthsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteNeurology

Advanced Tumors: TILs Treatment Study

We are studying a new therapy using tumor-infiltrating lymphocytes for patients with advanced tumors that have specific genetic changes. The goal is to see if this treatment can improve survival and tumor response.

Malignant Solid TumorEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Antithrombotic Therapy After Aortic Valve Implantation

We are studying whether a personalized, CT-guided antithrombotic therapy can better reduce serious heart and bleeding events compared to standard treatment in patients after transcatheter aortic valve implantation.

Aortic Valve StenosisMonitoring phase (IV)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Chronic Coccygodynia: Capsaicin 8% Patches

We are testing the effectiveness of capsaicin patches for people suffering from chronic tailbone pain. This study aims to see if these patches can provide better pain relief than a placebo.

Neuropathic PainChronic Coccygodynia>2 yearsConfirmation phase (III)Neurology