Search Clinical Trials in the European Union

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761-780 of 3,900 trials

Combination Therapies for Advanced Esophageal Cancer

We are studying new treatment combinations for patients with advanced esophageal cancer who have already been treated with PD-1/PD-L1 therapies. The aim is to evaluate their safety and how well they work in shrinking tumors and improving survival.

Advanced Esophageal Squamous Cell Carcinoma>2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteOncology

B-Cell Malignancies: SRG-1505 Treatment Study

We are testing a new treatment called SRG-1505 for individuals with mature B-cell malignancies. This study aims to evaluate its safety and appropriate dosage.

B-Cell Neoplasms and Lymphomas>2 yearsSafety phase (I)HematologyOncology

Colon Cancer Treatment: Neo-Adjuvant Chemotherapy for Seniors

We are studying whether a 6-week chemotherapy treatment before surgery helps older adults with resectable colon cancer live longer and stay disease-free. This trial aims to personalize treatment for patients aged 70 and older.

Colon Cancer>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOncology

Atopic Dermatitis: PF-07275315 and PF-07264660

We are investigating two new treatments for adults with moderate to severe atopic dermatitis. The study aims to see if they are more effective than a placebo in reducing eczema symptoms.

Atopic Dermatitis1-2 yearsEfficacy phase (II)6-10 visitsCost ReimbursementPartially RemoteAllergologyDermatology

Acute Pancreatitis: Omega-3 Fatty Acid Infusion

We are studying whether early intravenous omega-3 fatty acids can help reduce organ failure and mortality in patients with acute pancreatitis. This trial compares the effects of omega-3s to standard medical care.

Severe Acute Pancreatitis6-12 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesGastroenterologyInternal Medicine

Multiple Myeloma: Innovative Treatment Approaches

We are studying new methods to monitor multiple myeloma in patients who have not yet been treated. This trial compares different treatment combinations, including a stem cell transplant, to see which is more effective.

Multiple Myeloma6-12 monthsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesHematologyOncology

Type 1 Diabetes: New Cell Therapy for Children

We are studying a new treatment combining cell therapy and an antibody for children with early-stage type 1 diabetes. The goal is to see if this approach can help delay the onset of diabetes symptoms.

Prediabetes>2 yearsEfficacy phase (II)11-15 visitsInvestigational MedicinesEndocrinologyInfectious DiseasesPediatrics

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia

We are comparing a new treatment, bomedemstat, to hydroxyurea in people with essential thrombocythemia who haven't been treated before. The goal is to see which treatment better reduces symptoms and fatigue.

Essential Thrombocythemia>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteHematology

Blood Pressure Response: Multi-Omics Study

We are exploring how specific biomarkers can predict the effectiveness of blood pressure medications for individuals. This study aims to improve treatment personalization and understand potential side effects.

Essential Hypertension3-6 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine

COPD Treatment: Understanding ICS Response

We are studying how different eosinophil levels affect the response to inhaled corticosteroids in COPD patients. This research may help personalize treatment strategies for better management of the disease.

Chronic Obstructive Pulmonary Disease (COPD)1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyPulmonology

Heart Health: Adenosine Dose Study

We are investigating how different doses of adenosine affect blood flow in the heart for healthy individuals and patients with coronary artery disease. This study aims to understand if the response varies based on health status.

Chronic Ischemic Heart DiseaseMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Autism Spectrum Disorder: Sensorimotor Therapy and Oxytocin

We are exploring whether a new therapy combined with a single dose of oxytocin can improve social connections in children with autism. The goal is to see if this approach enhances their interactions with others.

Autism Spectrum Disorder>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPsychiatry

Osteoarthritis in the Thumb: Comparing Treatments

We are studying whether steroid injections are more effective than saline injections and occupational therapy for painful thumb osteoarthritis. The goal is to improve pain, function, and overall quality of life.

Osteoarthritis of the Thumb>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesOrthopedics and TraumatologyRheumatology

Acute Myeloid Leukemia: MP0533 Treatment Study

We are testing a new drug, MP0533, for patients with acute myeloid leukemia or myelodysplastic syndrome. The study aims to evaluate its safety and how well it may work against these blood cancers.

Myelodysplastic Syndrome (MDS)Acute Myeloid Leukemia (AML)Safety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesHematologyOncology

High-Risk Retroperitoneal Sarcoma: Chemotherapy Before Surgery

We are testing whether chemotherapy before surgery improves outcomes for patients with high-risk retroperitoneal sarcoma. This study compares the effects of preoperative chemotherapy to surgery alone.

Dedifferentiated LiposarcomaLeiomyosarcoma6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Advanced Solid Tumors: XON7 Antibody Study

We are investigating a new antibody treatment for patients with advanced or metastatic solid tumors. This study aims to evaluate its safety and how well it works in treating these cancers.

Advanced or Metastatic Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)Oncology

Glioblastoma Treatment: Lomustine with or without Reirradiation

We are studying whether adding a second round of radiation to lomustine improves survival and quality of life for patients with recurrent glioblastoma. This trial aims to find out if this combination is more effective than lomustine alone.

Glioblastoma>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Treatment-Resistant Depression: COMP360 Study

We are studying whether two doses of COMP360 can improve symptoms in adults with treatment-resistant depression. This trial includes psychological support to enhance treatment effects.

Major Depressive DisorderTreatment-Resistant Depression6-12 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Coronary Disease: Tirzepatide Study

We are exploring whether tirzepatide can improve heart health by changing plaque composition and blood flow in people with obesity and coronary artery disease. This study compares tirzepatide to a placebo to assess its effects.

Overweight and Obesity1-2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteCardiologyEndocrinology

Diffuse Large B-Cell Lymphoma: Epcoritamab with R-CHOP

We are studying whether adding Epcoritamab to standard R-CHOP treatment helps people with newly diagnosed Diffuse Large B-Cell Lymphoma live longer without disease progression. This trial compares the new combination to R-CHOP alone.

Diffuse Large B-Cell Lymphoma1-2 yearsConfirmation phase (III)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology