Search Clinical Trials in the European Union

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941-960 of 1,743 trials

Relapsed Multiple Myeloma: Daratumumab Treatment Study

We are comparing two treatment strategies using Daratumumab, Lenalidomide, and Dexamethasone for patients with relapsed multiple myeloma. The goal is to see if a fixed treatment duration is as effective as continuous therapy.

Myeloma Recurrence>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesHematologyOncology

Temozolomide for Non-enhancing Adult Brainstem Gliomas

We are studying the effects of Temozolomide chemotherapy in adults with specific types of brainstem gliomas. This trial aims to see how well it works for tumors that show an infiltrative pattern of growth.

Malignant GliomaBrain Stem Glioma>2 yearsEfficacy phase (II)NeurologyOncology

Severe Infections in ICU: Comparing Antibiotics

We are studying whether piperacillin-tazobactam or temocillin can effectively treat severe infections caused by certain bacteria in ICU patients, compared to standard carbapenem treatment. This research may help improve treatment options for critically ill patients.

ESBL-Producing Bacteria Infection>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboInvestigational MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Type 1 Diabetes: Metformin's Impact on Arterial Health

We are studying whether metformin can slow down artery calcification and improve blood flow in people with type 1 diabetes who do not have chronic kidney disease. This research may help us understand how to better manage cardiovascular risks in these patients.

Vascular CalcificationType 1 Diabetes>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesCardiologyEndocrinologyInternal Medicine

Fecal Microbiota Transfer for Diabetes Control After Bariatric Surgery

We are studying whether fecal microbiota transfer can help improve blood sugar levels in patients who had bariatric surgery and are in diabetes remission. This trial will explore its effects on insulin production and overall health.

Type 2 Diabetes>2 yearsConfirmation phase (III)Investigational MedicinesEndocrinologyInternal Medicine

COPD Exacerbation: New Diagnostic Strategy

We are testing a new method using advanced diagnostics to see if it can help reduce antibiotic use during severe COPD flare-ups. This study compares this approach to standard treatment to evaluate its effectiveness and safety.

Severe COPD with Ventilation Support>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPulmonology

Dermatomyositis: Baricitinib Treatment Study

We are studying whether baricitinib can help patients with dermatomyositis improve without using steroids. This trial compares its effects to a placebo while providing usual care.

Dermatomyositis>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesDermatologyRheumatology

Relapsed Primary CNS Lymphoma: High-Dose Methotrexate with Glucarpidase

We are exploring a new treatment approach for patients with relapsed primary CNS lymphoma. This study aims to assess the safety of combining high-dose methotrexate with glucarpidase.

Primary Central Nervous System Lymphoma>2 yearsSafety phase (I)Oncology

Pancreatic Cancer: FOLFOX vs. Gemcitabine

We are comparing two chemotherapy treatments, FOLFOX and gemcitabine, for patients with advanced pancreatic cancer who cannot tolerate a stronger regimen. The goal is to see which treatment works better and is safer for these patients.

Pancreatic Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Acromegaly: Paltusotine Treatment Study

We are studying the long-term safety and effectiveness of paltusotine for people with acromegaly. This research aims to improve treatment options for managing this condition.

Acromegaly>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteEndocrinology

Diffuse Cutaneous Systemic Sclerosis: Ianalumab Study

We are testing a new medication, ianalumab, for people with diffuse cutaneous systemic sclerosis. The goal is to see if it improves symptoms and lung function compared to a placebo.

Systemic Scleroderma>2 yearsEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteRheumatology

Pasireotide for Synovial Sarcoma and Desmoplastic Small Round Cell Tumor

We are studying whether pasireotide can help patients with specific cancers live longer without their disease progressing. This trial focuses on those with synovial sarcoma and desmoplastic small round cell tumor.

Locally Advanced or Metastatic Synovial SarcomaLocally Advanced or Metastatic Desmoplastic Small Round Cell Tumor>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

OT-A201 for Blood Cancers and Solid Tumors

We are testing a new treatment called OT-A201 in patients with certain blood cancers and solid tumors. This study aims to understand its safety and effectiveness in humans.

Relapsed or Refractory Hematological Malignancies and Advanced Solid Tumors>2 yearsSafety phase (I)Oncology

Cardiovascular Risk Management: BIO-RISK-EVENT Study

We are testing a new approach to managing heart health in patients at high risk for heart events. The goal is to see if this intensified treatment is more effective than standard care.

Heart Attack>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Oxygen Therapy for Acute Pulmonary Embolism

We are investigating whether supplemental oxygen helps patients with intermediate-risk acute pulmonary embolism improve their health and reduce hospital stays. The study also looks at its effects on survival rates over time.

Acute Pulmonary Embolism>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyPulmonology

Knee Osteoarthritis: Intra-Articular Clodronate Study

We are investigating whether different doses of clodronate can help reduce knee pain and improve function in people with painful knee osteoarthritis. The study will also monitor safety and tolerability of the treatment.

Knee Osteoarthritis>2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesOrthopedics and TraumatologyRheumatology

Prostate Cancer: Neoadjuvant Xaluritamig Study

We are testing a new treatment called Xaluritamig for men with newly diagnosed localized intermediate or high-risk prostate cancer. The goal is to see how well it works before surgery.

Localized Intermediate or High-Risk Prostate Cancer>2 yearsSafety phase (I)Oncology

Non-Hodgkin Lymphoma: New CAR T-Cell Therapy Study

We are comparing a new point-of-care CAR T-cell treatment to a standard commercial option for patients with relapsed or refractory Non-Hodgkin Lymphoma. The goal is to see if the new therapy can improve survival and safety outcomes.

Relapsed/Refractory Non-Hodgkin Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

HER2-Positive Glioblastoma: NK-92/5.28.z Cells and Ezabenlimab

We are investigating a new treatment combining NK-92/5.28.z cells with Ezabenlimab for patients with recurrent HER2-positive glioblastoma. This study aims to see if this combination can improve treatment outcomes.

Glioblastoma>2 yearsSafety phase (I)NeurologyOncology

Pneumonia in Preschool Children: Amoxicillin Study

We are investigating whether amoxicillin helps preschool children with pneumonia compared to a placebo. The study also looks at how the antibiotic affects airway bacteria and other related factors.

Community Acquired Pneumonia>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteInfectious DiseasesPulmonology