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81-100 of 3,900 trials

Multiple Myeloma: Anti-BCMA CAR T Cell Therapy

We are studying a new CAR T cell treatment for patients with relapsed or refractory Multiple Myeloma. The trial aims to evaluate its safety and effectiveness in improving patient outcomes.

Relapsed/Refractory Multiple Myeloma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Acute Myeloid Leukemia: New Treatments for Children and Adolescents

We are exploring different therapies for children and adolescents with acute myeloid leukemia to see if they improve survival and treatment outcomes. This includes testing new drugs alongside standard chemotherapy.

Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyPediatrics

Eosinophilic Gastritis: Dupilumab Treatment Study

We are investigating how well dupilumab works for adults and adolescents with eosinophilic gastritis, with or without eosinophilic duodenitis. The study will also look at the safety and side effects of this treatment.

Eosinophilic Gastritis1-2 yearsEfficacy phase (II)Post-Trial Drug AccessStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Multiple Myeloma: Linvoseltamab Treatment Study

We are investigating the safety and effectiveness of linvoseltamab in patients with newly diagnosed multiple myeloma who have not yet received treatment. This study will help us understand how well this new therapy works for different patient groups.

Multiple MyelomaEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteHematologyOncology

Multiple Myeloma: KTX-1001 Treatment

We are testing different amounts of KTX-1001 to see if it is safe and tolerable for people with relapsed or treatment-resistant multiple myeloma.

Relapsed and Refractory Multiple Myeloma>2 yearsSafety phase (I)HematologyOncology

Advanced Non-Small Cell Lung Cancer: Datopotamab Deruxtecan and Pembrolizumab

We are studying a new treatment combination for patients with advanced non-small cell lung cancer who have not had prior therapy. The goal is to see if this combination works better than standard treatments in improving survival and reducing disease progression.

Advanced Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOncology

Arrhythmic Mitral Valve Prolapse: Flecainide and Metoprolol Study

We are studying whether adding flecainide to metoprolol can better reduce irregular heartbeats in patients with arrhythmic mitral valve prolapse. This trial aims to assess the safety and effectiveness of this combination treatment.

Mitral Valve Prolapse>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Prostate Cancer: Neoadjuvant Treatment with [177Lu]Lu-PSMA-617

We are studying a new method of delivering a targeted treatment for men with high-risk prostate cancer before surgery. The goal is to evaluate its safety and how well it works compared to standard approaches.

High-Risk Prostate Cancer3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncologyUrology

Advanced Solid Tumors: TT125-802 Treatment Study

We are testing a new treatment for people with advanced solid tumors to see how safe it is and how well it works. This study will help us learn more about its effects in humans.

Advanced Solid Tumors1-2 yearsSafety phase (I)Oncology

Atrial Fibrillation: Colchicine Study

We are investigating whether colchicine can help prevent the return of atrial fibrillation in patients scheduled for heart rhythm treatment. We will also look at its effects on heart health and quality of life.

Atrial Fibrillation and Atrial Flutter>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiology

ERASE PH-COPD: New Treatment for COPD

We are exploring a new approach for individuals with chronic obstructive pulmonary disease (COPD). The goal is to see if this treatment can improve breathing and overall health.

Pulmonary Hypertension6-12 monthsConfirmation phase (III)Pulmonology

Achilles Tendinopathy: NGI226 Microparticles Study

We are investigating the safety and effects of NGI226 microparticles for patients with Achilles tendinopathy. This study aims to see if it helps restore tendon strength compared to a placebo.

Achilles Tendinopathy6-12 monthsEfficacy phase (II)>20 visitsInvestigational MedicinesInternal MedicineOrthopedics and Traumatology

Post-Traumatic Stress Disorder: Testing New Therapy

We are studying a new therapy called reconsolidation therapy for people with severe PTSD. This trial compares it to standard treatment and looks at whether adding propranolol can improve outcomes.

Post-Traumatic Stress Disorder≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesPsychiatry

Acyclovir Dosage for Obese Patients

We are exploring how to personalize acyclovir dosages for individuals with obesity. This study aims to improve treatment effectiveness and safety for this patient group.

ObesitySafety phase (I)Infectious DiseasesInternal Medicine

Type 1 Diabetes: INVITED Trial on Flu Vaccine

We are studying whether influenza vaccination can help protect insulin-producing cells in individuals with early type 1 diabetes. This research aims to find new ways to support diabetes management.

Type 1 Diabetes>2 yearsEfficacy phase (II)Standard MedicinesEndocrinologyInfectious Diseases

Aspirin for Preventing Preeclampsia in First-Time Pregnant Women

We are studying whether daily aspirin can help prevent preeclampsia and improve pregnancy outcomes in women who are pregnant for the first time after assisted reproductive technology. This trial compares aspirin to a placebo to see which is more effective.

Preeclampsia>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesPartially RemoteGynecology and Obstetrics

Esophageal Cancer Treatment: The NEEDS Trial

We are comparing two treatment methods for operable esophageal squamous cell carcinoma to see which may help patients survive longer. The study also examines quality of life and other health impacts during and after treatment.

Locally Advanced Esophageal Squamous Cell Carcinoma≤3 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesPartially RemoteOncology

Melanoma Treatment: Nivolumab + Relatlimab Injection Study

We are comparing a new way to give a combination treatment for advanced melanoma to see if it works as well as the traditional method. This study is for people who have not yet been treated for their melanoma.

Metastatic MelanomaConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementDermatologyOncology

Acute Venous Thromboembolism: Anticoagulant Therapy Study

We are studying whether full-dose anticoagulant therapy alone is safer and more effective than combining it with antiplatelet therapy for patients with acute VTE. This research aims to improve treatment options for those already taking antiplatelets.

Deep Venous Thrombosis and Pulmonary Embolism>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Merkel Cell Carcinoma: Pembrolizumab with Chemotherapy

We are studying a new treatment combining pembrolizumab with chemotherapy for patients with advanced Merkel cell carcinoma. The goal is to see if this combination is effective and safe for those who haven't been treated before.

Merkel Cell CarcinomaEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology