Search Clinical Trials in the European Union

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101-120 of 552 trials

Brain Injury: Effects of Ketamine Treatment

We are studying whether adding ketamine to treatment helps lower the intensity of care needed for patients with acute brain injuries. We also want to see if it affects intracranial pressure.

Traumatic Brain Injury>2 yearsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesNeurologyOtolaryngology

Influenza Vaccine After Heart Attack: ELIMINATE Trial

We are studying whether an influenza vaccine can help reduce heart inflammation in people who have had a heart attack. This trial compares the vaccine to a placebo to see its effects on heart health.

Heart Attack>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesCardiologyInfectious Diseases

Nutrition Timing After Major Abdominal Surgery

We are comparing early versus delayed nutrition support for patients recovering from major emergency abdominal surgery. The goal is to see which approach may lower the risk of infections after surgery.

Major Emergency Abdominal Surgery≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesGastroenterology

Chronic Rhinosinusitis: Mepolizumab and Nasal Polypectomy Study

We are investigating whether combining Mepolizumab with in-office nasal polypectomy can improve quality of life for patients with chronic rhinosinusitis. The study will assess symptom relief and safety over time.

Chronic Rhinosinusitis with Nasal Polyps6-12 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Bacterial Brain Abscess: Oral vs. IV Antibiotics

We are studying whether oral antibiotics are as effective as IV antibiotics for treating bacterial brain abscesses. This trial will help us understand the best treatment options and their impact on recovery and quality of life.

Brain Abscess>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesNeurology

Long-term Safety Study for Ciltacabtagene Autoleucel

We are following up with patients who received cilta-cel to learn about any long-term side effects and how well the treatment works over time. This study aims to improve our understanding of the treatment's safety and effectiveness.

Multiple Myeloma>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementHematologyOncology

Ceftazidime-Avibactam for Critically Ill Patients

We are studying the best dosing of ceftazidime-avibactam for critically ill patients on continuous renal replacement therapy. This research aims to improve treatment effectiveness and safety.

Ceftazidime-avibactam Therapy1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesNephrology

Refractory Heart Failure: Dapagliflozin Study

We are investigating how Dapagliflozin may help patients with refractory heart failure eliminate sodium and manage fluid levels during peritoneal dialysis. This study aims to improve treatment options for these patients.

Refractory Heart Failure≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal MedicineNephrology

Chronic Kidney Disease: Patiromer Study

We are testing whether patiromer helps patients with chronic kidney disease better manage their blood pressure and reduce protein in urine. This study aims to improve treatment options for those with advanced kidney disease.

Chronic Kidney Disease6-12 monthsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementCardiologyNephrology

Prostate Cancer: Abiraterone and Oxycodone Study

We are investigating how abiraterone affects the metabolism of oxycodone in men with prostate cancer. This may help improve pain management for patients using these medications.

Prostate Cancer≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOncologyUrology

Klinefelter Syndrome: Testosterone Treatment in Puberty

We are studying how testosterone replacement therapy affects boys with Klinefelter syndrome during puberty. This includes looking at changes in body composition, growth, and overall development.

Klinefelter Syndrome>2 yearsMonitoring phase (IV)Standard MedicinesEndocrinologyUrology

Heart Surgery: Buckberg vs. Del Nido Cardioplegia

We are comparing two heart protection solutions used during surgery to see which one better safeguards the heart and leads to fewer complications. This study is for patients undergoing isolated myocardial revascularization surgery.

Cardiovascular DiseaseMonitoring phase (IV)No PlaceboStandard Medicines

Stem Cell Transplantation vs. Immunosuppressive Therapy for Systemic Sclerosis

We are studying whether upfront stem cell transplantation is more effective than immunosuppressive medication for early diffuse cutaneous systemic sclerosis. This trial will help us understand the best treatment approach for improving survival and quality of life.

Diffuse Cutaneous Systemic SclerosisMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesRheumatology

Peptide Receptor Radionuclide Therapy: LA-SSA Study

We are investigating how a long-acting medication affects radiation doses in tumors and normal tissues during treatment for certain cancers. This may help improve the effectiveness and safety of future therapies.

Neuroendocrine Tumors (NETs)3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Obesity Surgery: Opioid Sparing Care Pathway

We are studying a new pain management approach for patients undergoing obesity surgery to see if it helps reduce opioid use and improve recovery. This may lead to better health outcomes and less reliance on pain medications.

Postoperative PainObesity>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngology

Osteoporosis Treatment: The OPTIMIST Study on Romosozumab

We are exploring the best ways to use romosozumab for osteoporosis treatment. Additionally, we’re investigating if it has any impact on insulin sensitivity.

Osteoporosis>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Pain Management: Dexmedetomidine for Nerve Block

We are exploring the best dose of dexmedetomidine to enhance pain relief during a nerve block procedure. This study will also check for side effects and benefits like reduced opioid use and better patient satisfaction.

Patients Scheduled for Shoulder Operations1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOrthopedics and TraumatologyOtolaryngology

Heart Failure: Trimetazidine Study

We are investigating how trimetazidine affects heart function and health markers in people with heart failure. The goal is to see if it can improve symptoms and reduce hospital visits.

Heart Failure with Preserved Ejection Fraction1-2 yearsMonitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

Breast Reconstruction: Goal-Directed Fluid Therapy

We are studying how a specific fluid management approach during DIEP breast reconstruction may reduce swelling and improve healing. This trial aims to see if it helps with better blood flow to the surgical area.

Low Blood Pressure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal MedicineOtolaryngology

Atopic Dermatitis: Personalized Treatment Approaches

We are studying how genetic and biochemical markers can help choose the best treatment for patients with atopic dermatitis needing stronger therapies. This research may lead to better management strategies tailored to individual needs.

Atopic Dermatitis6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesAllergologyDermatology