Search Clinical Trials in the European Union

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101-120 of 1,743 trials

Pancreatic Cancer: KISIMA-02 Vaccine Therapy

We are testing a new vaccine-based immunotherapy for patients with pancreatic cancer. This study aims to see if it can enhance the effectiveness of current treatments.

Pancreatic Cancer>2 yearsSafety phase (I)Oncology

Remifentanil for Intubation in Newborns

We are studying the best dose of remifentanil to safely sedate newborns during intubation. Our goal is to ensure effective sedation with minimal side effects.

Stable Neonates Requiring Intubation>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPediatrics

Leukemia and Lymphoma: Ruxolitinib and Venetoclax Study

We are studying the safety and effectiveness of ruxolitinib and venetoclax in children with relapsed or refractory leukemia or lymphoma that have specific genetic mutations. This research aims to find better treatment options for these young patients.

Lymphoblastic Lymphoma and Acute Lymphoblastic Leukemia>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementHematologyOncology

Takotsubo Syndrome: New Treatment Approaches

We are studying whether a combination of adenosine and dipyridamole improves outcomes for patients with Takotsubo Syndrome. Additionally, we’re testing if apixaban can lower the risk of blood clots in these patients.

Takotsubo Syndrome>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteCardiologyInternal Medicine

Chronic Lymphocytic Leukemia: Mosunetuzumab and Venetoclax Study

We are testing a new treatment combining Mosunetuzumab and Venetoclax for patients with relapsed or refractory chronic lymphocytic leukemia. The goal is to evaluate its safety and effectiveness compared to Mosunetuzumab alone.

Chronic Lymphocytic Leukemia>2 yearsSafety phase (I)Oncology

Acute Ischemic Stroke: Redasemtide Study

We are investigating whether redasemtide can improve recovery in adults who have had an acute ischemic stroke. Participants will receive either the medication or a placebo to compare effects.

Ischaemic Stroke>2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyNeurology

Prostate Cancer Imaging: PSMA-PET vs. mpMRI

We are comparing two imaging methods to see which better identifies critical areas in high-risk prostate cancer. This study may help improve diagnosis and treatment planning for patients.

Prostate Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyUrology

Rituximab for Heart Attack Recovery

We are studying whether a single injection of rituximab can improve heart function in patients who have had a heart attack. This trial compares its effects to a placebo to see if it helps reduce heart damage.

ST Segment Elevation Myocardial InfarctionAcute Myocardial Infarction>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Prostate Cancer: Apalutamide with Radiation Therapy

We are studying whether adding stereotactic body radiation therapy to Apalutamide improves treatment outcomes for men with low burden metastatic hormone-sensitive prostate cancer. This trial compares standard treatment alone to the combination therapy.

Prostate Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncologyUrology

Ovarian Cancer: Niraparib and Abemaciclib Combination

We are studying the effects of combining niraparib and abemaciclib for patients with late-stage ovarian cancer. This trial aims to see if this treatment can improve outcomes for those who have already received other therapies.

Ovarian Cancer>2 yearsSafety phase (I)Efficacy phase (II)Gynecology and ObstetricsOncology

Multiple Myeloma: Belantamab Treatment Study

We are investigating the safety and effectiveness of belantamab for treating multiple myeloma, both on its own and with other therapies. This study aims to find out how well it works for patients.

Multiple Myeloma>2 yearsSafety phase (I)Efficacy phase (II)HematologyOncology

Gastrectomy: Pancreatic Enzyme Supplementation

We are investigating if taking pancreatic enzymes with meals improves quality of life for patients after gastrectomy. This study aims to see how these enzymes may help in recovery.

Patients after Gastrectomy>2 yearsConfirmation phase (III)Investigational MedicinesGastroenterologyInternal Medicine

Oxygen Therapy for AECOPD: Standard vs Targeted Approach

We are investigating whether a targeted oxygen therapy can reduce mortality and improve breathing in patients with acute exacerbations of chronic obstructive pulmonary disease. This study compares it to standard oxygen treatment to see which is more effective.

COPD Exacerbation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Kidney Transplant: Comparing rATG and Basiliximab

We are studying whether rATG is more effective than basiliximab in preventing kidney transplant rejection in sensitized patients without pre-existing antibodies. This trial aims to improve outcomes for kidney transplant recipients.

Kidney Transplant>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesNephrology

Acute Myeloid Leukemia: Comparing Treatment Regimens

We are studying two different conditioning regimens for adults with acute myeloid leukemia before stem cell transplantation. The goal is to see which regimen may improve survival and recovery outcomes.

Acute Myeloid Leukemia in Remission>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematology

Hemophilia A: Dendritic Cell Therapy

We are testing a new treatment using patients' own dendritic cells to help manage severe bleeding in hemophilia A. This study aims to see if it can improve the body's tolerance to a crucial clotting factor.

Hemophilia A with Anti Factor VIII>2 yearsSafety phase (I)Hematology

Crohn's Disease: Risankizumab for Children

We are studying the safety and effectiveness of risankizumab in children aged 2 to under 18 with moderately to severely active Crohn's disease. This trial aims to help those who haven't responded to other treatments.

Crohn's Disease>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteGastroenterologyInternal Medicine

Semaglutide for Glucose Intolerance in Women with Prior Gestational Diabetes

We are studying whether semaglutide can help women with a history of gestational diabetes manage glucose intolerance and reduce the risk of developing type 2 diabetes.

Prediabetes>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyGynecology and Obstetrics

Small Cell Lung Cancer: Niraparib with Immunotherapy

We are studying the effects of adding niraparib to immunotherapy for patients with SLFN11-positive small cell lung cancer. This research aims to see if it improves treatment after initial therapy.

Extensive Stage Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Primary IgA Nephropathy: RO7434656 Treatment Study

We are testing a new medication to see if it helps reduce protein in urine and improves kidney function in patients with Primary IgA Nephropathy at high risk of progression. The study will also evaluate safety and fatigue levels.

IgA Nephropathy>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteNephrology