Search Clinical Trials in the European Union

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1261-1280 of 1,738 trials

Epiflux: Investigating a New Treatment

We are exploring a new treatment called Epiflux for patients with a specific health condition. Our goal is to understand its effects and potential benefits compared to existing options.

Focal Epilepsy>2 yearsEfficacy phase (II)Neurology

CRD-4730 for Catecholaminergic Polymorphic Ventricular Tachycardia

We are studying a new medication, CRD-4730, to see if it is safe and tolerable for people with CPVT. The trial will also assess its effects on heart rhythm during exercise.

Catecholaminergic Polymorphic Ventricular TachycardiaEfficacy phase (II)Investigational MedicinesPartially RemoteCardiologyHematologyInternal Medicine

Hydroxychloroquine for Recurrent Pregnancy Loss

We are studying whether Hydroxychloroquine can help women with recurrent pregnancy loss achieve a live birth. The trial also examines pregnancy outcomes and potential complications compared to a placebo.

Recurrent Pregnancy Loss6-12 monthsEfficacy phase (II)Standard MedicinesGynecology and Obstetrics

Metastatic Colorectal Cancer: FLIRT Treatment Study

We are testing a combination of chemotherapy and targeted therapy for patients with a specific type of metastatic colorectal cancer. This study aims to see if this new approach improves treatment outcomes.

Metastatic Colorectal Cancer>2 yearsSafety phase (I)Efficacy phase (II)GastroenterologyOncology

Bone Health: AGA2118 for Postmenopausal Women

We are studying whether AGA2118 can improve bone density in postmenopausal women with low bone mass. The trial compares its effects to a placebo over 12 months.

Postmenopausal OsteoporosisEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementEndocrinologyOrthopedics and TraumatologyRheumatology

Chronic Spontaneous Urticaria and Hidradenitis Suppurativa: INF904 Study

We are evaluating the safety of an oral medication called INF904 for people with moderate to severe chronic spontaneous urticaria or hidradenitis suppurativa. This study will help us understand how the medication works in the body.

Chronic Spontaneous UrticariaHidradenitis Suppurativa≤3 monthsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Medulloblastoma Treatment: MEMMAT Trial

We are studying a combination of anti-cancer drugs for children with recurrent brain tumors. The goal is to see if this treatment improves response rates and overall survival.

Rare CNS Tumors≤3 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncology

Kidney Disease: VX-147 Study for APOL1 Variants

We are testing the safety and effectiveness of VX-147 in adults and children with APOL1-mediated proteinuric kidney disease. The study aims to see if this treatment can improve kidney function and reduce related health risks.

APOL1-mediated Proteinuric Kidney Disease>2 yearsEfficacy phase (II)Confirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteNephrology

Carotid Artery Disease: [18F]AlF-NOTA-octreotide PET/MRI Study

We are exploring a new imaging method to better understand carotid artery disease in patients who have had a recent stroke or TIA. This study aims to see if it can help identify those at risk for future strokes.

Carotid Artery Atherosclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Chronic Lymphocytic Leukemia: APG-2575 Study

We are studying a new medication, APG-2575, for patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The trial will evaluate its safety and effectiveness alone and with other treatments.

Chronic Lymphocytic Leukemia (CLL)1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Actinic Keratosis: Keramod Gel vs. Aldara Cream

We are studying whether Keramod Gel works better than Aldara Cream for treating actinic keratosis in adults. The trial will also assess safety and how well patients tolerate each treatment.

Actinic Keratosis3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesDermatology

Metastatic Tumors: Atezolizumab with SABR

We are studying the effects of a new combination treatment of atezolizumab and radiotherapy for patients with metastatic tumors. This trial aims to see if this approach can help improve survival rates and understand its safety.

Metastatic Tumors3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Colorectal Cancer: Temozolomide and Irinotecan Treatment

We are studying a combination of temozolomide and irinotecan for patients with specific colorectal cancer characteristics after standard chemotherapy. The goal is to see if this treatment helps eliminate remaining cancer cells and improves survival.

Stage II/III Colorectal Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

BRCA-related Metastatic Breast Cancer: Pembrolizumab and Carboplatin Study

We are testing a combination of Pembrolizumab and Carboplatin for patients with BRCA-related metastatic breast cancer. The goal is to see if this treatment improves response rates and safety compared to existing options.

Stage IV Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Ghrelin for Acute Ischemic Stroke Treatment

We are studying whether ghrelin can improve recovery in patients with acute ischemic stroke treated with endovascular thrombectomy. The trial will also assess its effects on overall health and safety over several days.

Ischemic Stroke1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyNeurology

Heart Failure: Engineered Heart Tissue Treatment

We are studying a new type of heart tissue made from stem cells for patients with severe heart failure. The goal is to see if it is safe and effective in improving heart function and related symptoms.

Acute Heart Failure>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCardiologyInternal Medicine

Optic Pathway Glioma: CHF6467 Eye Drops

We are studying the safety and effectiveness of a new eye drop treatment for children and young adults with optic pathway gliomas. This trial aims to see if it can improve their vision.

Optic Glioma≤3 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesNeurologyOphthalmology

Non-Small Cell Lung Cancer: BNT327 with Chemotherapy

We are studying the safety and effectiveness of BNT327, an investigational therapy, combined with chemotherapy for patients with non-small cell lung cancer. This trial compares it to standard treatments to see which works better.

Non-small cell lung cancer>2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Pulmonary Hypertension: Sotatercept Study

We are investigating the safety and effects of sotatercept in individuals with pulmonary hypertension due to heart failure. This study aims to understand how well the treatment works over time.

Pulmonary Hypertension>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine

Chronic Infection in Hip and Knee Implants: 68Ga PET/CT Study

We are investigating whether a new imaging technique can accurately diagnose chronic infections in artificial hip and knee joints. This study compares its effectiveness to other existing diagnostic methods.

Prosthetic Joint Infection>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and TraumatologyOtolaryngology