Search Clinical Trials in the European Union

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1321-1340 of 1,738 trials

Neuroendocrine Neoplasms: Advanced PET/CT Imaging Study

We are exploring how combined PET/CT scans can help predict survival outcomes for patients with neuroendocrine neoplasms. This study may also identify who is eligible for targeted therapies based on imaging results.

Neuroendocrine Carcinoma1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesEndocrinologyOncology

Recurrent Brain Tumors in Children: Ultrasound Blood-Brain Barrier Study

We are evaluating a new ultrasound device to safely open the blood-brain barrier before chemotherapy in children with recurrent brain tumors. This study aims to see how well this method works and its effects on tumor progression.

Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesNeurologyOncologyPediatrics

COPD Management: Azithromycin Based on Mucus Properties

We are studying whether prescribing azithromycin based on mucus rheology helps reduce COPD flare-ups compared to standard treatment. This trial aims to improve care for patients with chronic airway disease.

Chronic Obstructive Pulmonary Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicinePulmonology

B-Cell Lymphoma: Valemetostat Tosylate Study

We are testing a new treatment for patients with relapsed or refractory B-cell lymphoma. The study aims to see how well it works and its safety across different lymphoma types.

Relapse/Refractory B-Cell Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Liver Transplant: QEL-001 Treatment Study

We are testing a new CAR T cell therapy for patients who received an HLA-A2 mismatched liver transplant. The goal is to evaluate its safety and how well it works in this specific group.

Liver Transplant Rejection3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHepatologyInternal Medicine

Glioblastoma Multiforme: Long-Term Safety of Temferon

We are monitoring the long-term safety and effects of Temferon in patients who have been treated for glioblastoma multiforme. This study aims to understand any potential side effects and how the disease may progress.

Glioblastoma MultiformeSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteNeurologyOncology

Colorectal Cancer: Dendritic Cell Vaccine Study

We are testing a personalized vaccine made from patients' own cells after surgery for stage IV colorectal cancer. The goal is to see if it safely boosts the immune response against cancer.

Stage IV Colorectal Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesOncology

B-Cell Malignancies: BGB-16673 Treatment Study

We are investigating the safety and effectiveness of BGB-16673 combined with other treatments for patients with relapsed or refractory B-cell malignancies. This study aims to find the best dose and assess how well the treatment works.

Relapsed or Refractory B-Cell Malignancies>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Cryoglobulinemia Vasculitis: Belimumab Study

We are studying whether belimumab can help people with non-infectious active cryoglobulinemia vasculitis compared to a placebo. The goal is to see if it improves symptoms and overall health.

Cryoglobulinemia Vasculitis6-12 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementInfectious DiseasesRheumatology

Wrist Osteoarthritis: Microfat and PRP Injection Study

We are testing whether injections of your own fat and platelet-rich plasma can help relieve pain in wrist osteoarthritis compared to standard surgery. This study aims to see if the new treatment is just as effective and safe.

Wrist Osteoarthritis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOrthopedics and TraumatologyRheumatology

Metastatic Thyroid Cancer: Personalized 131I Therapy

We are studying if a personalized approach to administering radioactive iodine can improve treatment outcomes for patients with metastatic thyroid cancer. This trial also looks at how genetic factors may affect treatment effectiveness.

Thyroid Cancer>2 yearsEfficacy phase (II)Standard MedicinesOncology

Fertility Preservation for Breast Cancer: Tamoxifen and Ovarian Stimulation

We are studying whether combining Tamoxifen with ovarian stimulation can help women with breast cancer collect healthy eggs before chemotherapy. This may support their chances of having children in the future.

Breast CancerEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Liver Cirrhosis: RTX001 Macrophage Therapy

We are studying a new treatment using RTX001 autologous macrophages for people with decompensated liver cirrhosis. The trial aims to evaluate its safety and effectiveness in improving liver function.

Liver Cirrhosis>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteHepatologyInternal Medicine

Sjögren’s Disease: Sibeprenlimab Treatment Study

We are investigating whether Sibeprenlimab can improve symptoms in people with Sjögren’s Disease compared to a placebo. The study will also look at the safety and tolerability of this new treatment.

Sjögren's Disease1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementInfectious DiseasesRheumatology

Lung Fibrosis in Systemic Rheumatic Diseases: Imaging Study

We are investigating whether advanced imaging can help identify early signs of lung fibrosis in patients with systemic rheumatic diseases. This may help us understand lung function changes and improve patient care.

Connective Tissue Disease with Risk of Lung Disease1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPulmonologyRheumatology

Oxytocin for Children with Autism and Intellectual Disabilities

We are studying whether oxytocin can safely support educational measures for children aged 6 to 12 with autism and intellectual disabilities. This trial will help us understand its feasibility and safety in managing challenging behaviors.

Autism Spectrum Disorder and Intellectual Disability>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPediatricsPsychiatry

Metastatic Colorectal Cancer: Nivolumab and Ipilimumab Study

We are testing a combination of two immunotherapy drugs for patients with metastatic colorectal cancer that is resistant to previous treatments. This study aims to find out if this combination can improve outcomes for these patients.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)Oncology

HER2 Positive Esophageal Cancer: HERES Trial

We are studying whether adding trastuzumab to standard chemotherapy and immunotherapy helps patients with HER2 positive esophageal squamous cell carcinoma live longer without disease progression.

Esophageal Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology

Type 3 Spinal Muscular Atrophy: NMD670 Study

We are testing the safety and effectiveness of NMD670 in adults with Type 3 spinal muscular atrophy. The study aims to see if it improves muscle strength and function compared to a placebo.

Spinal Muscular Atrophy Type III3-6 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementNeurologyOrthopedics and Traumatology

Metastatic Pancreatic Cancer: 5-FU with NALIRI or NALIRINOX

We are studying two new treatment combinations for patients with metastatic pancreatic ductal adenocarcinoma who have progressed after prior therapies. The aim is to see if these combinations improve survival and are safe to use.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology