Search Clinical Trials in the European Union

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121-140 of 240 trials

Chronic Depression: Ketamine Treatment Study

We are investigating whether adding ketamine to a therapy for chronic depression can reduce symptoms more effectively than a placebo. This study aims to help improve treatment options for those struggling with depression.

Chronic Depression≤3 monthsEfficacy phase (II)Standard MedicinesPsychiatry

Colon Cancer: Neoadjuvant Dostarlimab Treatment

We are studying the effects of Dostarlimab in patients with untreated Stage III colon cancer. This trial aims to understand how well the treatment works and its safety before surgery.

Resectable Colon Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGastroenterologyOncology

X-Linked Hypohidrotic Ectodermal Dysplasia: ER004 Treatment

We are studying a new prenatal treatment for male infants with X-linked hypohidrotic ectodermal dysplasia to see if it improves sweating ability and dental health. The trial also examines the safety of this treatment for both the infants and their mothers.

X-linked Hypohidrotic Ectodermal Dysplasia≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteDermatologyInternal MedicinePediatrics

Vaginal Progesterone for IVF: Improving Live Birth Rates

We are studying whether vaginal progesterone helps women achieve live births after frozen embryo transfer. The trial compares outcomes between those receiving progesterone and those who do not.

Infertility≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Metastatic Colorectal Cancer: Telisotuzumab Adizutecan Study

We are investigating a new treatment combination for people with metastatic colorectal cancer to see if it works better and is safer than current standard treatments.

Metastatic Colorectal Cancer≤3 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Major Depression: Samyr® Tablet Study

We are investigating whether Samyr® tablets can improve symptoms in patients with major depressive disorder who are not fully responding to their current treatment. The study compares Samyr® to a placebo to assess its effectiveness and safety.

Major Depression Disorder≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemotePsychiatry

Major Depression: Samyr Injection Study

We are testing whether Samyr, an injectable treatment, can improve symptoms in people with major depression who are not responding well to their current antidepressants. This study compares Samyr to a placebo to assess its effectiveness and safety.

Major Depression Disorder≤3 monthsConfirmation phase (III)11-15 visitsInvestigational MedicinesPsychiatry

Bipolar Mania: Lumateperone Study

We are evaluating the safety and effectiveness of lumateperone for treating manic episodes in patients with bipolar I disorder. This study compares the medication to a placebo to see how well it works.

Bipolar Disorder≤3 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPsychiatry

RSV Vaccination in Stem Cell Transplant Recipients

We are studying two RSV vaccines to see how well they work in patients who have received stem cell transplants. The goal is to understand their immune response and effectiveness compared to healthy individuals.

Allogeneic Hematopoietic Stem Cell Transplantation≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematologyInfectious DiseasesInternal Medicine

Early-Stage Colon Cancer: NICHE Trial for Immunotherapy

We are studying a new immunotherapy treatment for patients with early-stage colon cancer to see if it can reduce tumors before surgery. The trial also aims to identify biomarkers that may help tailor treatments and improve patient outcomes.

Colon or Rectosigmoid Adenocarcinoma≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncology

Cancer Treatments: Impact on Speech and Quality of Life

We are studying how different cancer treatments affect speech understanding in noise and overall quality of life for patients. This research may help us understand the cognitive effects of these treatments over time.

Bladder CancerTesticular SeminomaHead and Neck Cancer≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesOncologyPsychiatry

CSL889 for Sickle Cell Disease: A New Treatment

We are studying the safety and effects of CSL889 in adults and adolescents with sickle cell disease during painful vaso-occlusive crises. The goal is to see if it helps speed up recovery compared to a placebo.

Sickle Cell Anemia with Crisis≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteHematologyInternal Medicine

Mindfulness Training and Oxytocin for Stress Relief

We are studying whether combining oxytocin treatment with mindfulness training can better reduce stress in adults with high stress levels. This trial will measure changes in psychological distress and other related factors.

Psychological Distress≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost Reimbursement

Preventing C. difficile Infections: Oral Vancomycin for Stem Cell Transplant Patients

We are studying if oral vancomycin can help prevent infections in patients receiving allogeneic stem cell transplants. This research aims to see if it reduces the risk of Clostridium difficile infections during their hospital stay.

Clostridium Difficile InfectionPatients Hospitalized for Allogeneic Hematopoietic Stem Cell Transplantation≤3 monthsConfirmation phase (III)Standard MedicinesPartially RemoteHematologyInfectious Diseases

COPD: Dronabinol for Breathlessness Relief

We are studying whether Dronabinol can help people with severe and very severe COPD experience less breathlessness. This trial will compare its effects against a placebo.

Chronic Obstructive Pulmonary Disease≤3 monthsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessStandard MedicinesInternal MedicinePulmonology

Migraine Prevention: Comparing Common Medications

We are studying how well different medications prevent migraines in primary care patients. This trial aims to find out which treatment reduces migraine days and improves quality of life.

Migraine Headaches≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurology

Cytoreductive Surgery: HiPRESS Study

We are testing if low-dose argipressin can reduce fluid use and improve recovery during surgery for cancer treatment. This study compares it to standard treatment to see which is better for patients.

Disseminated Cancer≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and Traumatology

Atrial Fibrillation: Dapagliflozin Treatment Study

We are investigating if dapagliflozin can help prevent the return of atrial fibrillation after cardioversion compared to usual care. This study aims to see how well it works in prolonging the time before atrial fibrillation recurs.

Atrial Fibrillation≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Chronic Kidney Disease: Sevuparin Treatment Study

We are investigating how sevuparin may improve kidney function and anemia in people with chronic kidney disease. The study will assess safety and how the drug works in the body.

Chronic Kidney Disease≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteHematologyNephrology

Flu Vaccine Study: LAIV in Young Children

We are studying how the LAIV flu vaccine affects the immune response in young children. This research aims to see how well it protects against flu and influences overall health.

Influenza≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPediatricsPulmonology