Search Clinical Trials in the European Union

>2 years
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1621-1640 of 1,743 trials

Critical Limb Ischemia: L-PRF Treatment Study

We are investigating the safety of a new treatment using patient-derived fibrin for individuals with critical limb ischemia. The study also looks at its potential effects on limb health and quality of life.

Critical Limb Ischemia>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Glioblastoma: Dendritic Cell Immunotherapy Study

We are evaluating a new immune therapy for patients with glioblastoma to see if it improves survival and quality of life compared to standard treatments.

Glioblastoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesOncology

Alzheimer's Disease: The ExPlas Study on Plasma Transfusions

We are investigating whether plasma from exercise-trained donors is safe and can improve cognitive function in people with early Alzheimer's disease. This study will help us understand its effects over several years.

Early Symptomatic Phase Alzheimer's Disease>2 yearsEfficacy phase (II)11-15 visitsInvestigational MedicinesInternal MedicineNeurology

Acute Cholecystitis: Indocyanine Green in Surgery

We are testing whether indocyanine green can help reduce surgery time and improve safety during gallbladder removal in patients with acute cholecystitis. This study aims to enhance surgical outcomes and patient satisfaction.

Acute Cholecystitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

MOTHER Trial: Low-Dose Morphine for Cesarean Section Pain

We are studying whether adding a low dose of morphine to standard pain management helps reduce pain after a planned cesarean section. The trial also looks at the safety for both mothers and their newborns.

Planned Caesarean Section>2 yearsMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsOtolaryngology

Prostate Cancer: HIFU and Hormone Therapy Study

We are testing a combination of high-intensity focused ultrasound and short-term hormone therapy for men with intermediate-risk localized prostate cancer. The goal is to see if this approach improves cancer control and maintains sexual and urinary functions.

Intermediate Risk Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyUrology

Heart Failure: Empagliflozin and Dapagliflozin Study

We are investigating how two medications may improve outcomes for patients hospitalized with acute heart failure. The study looks at their effects on heart function and other health indicators.

Acute Decompensated Heart Failure>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

Medication-Related Osteonecrosis of the Jaw>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Apathy After Stroke: Brain Pathway Study

We are examining how cholinergic and dopaminergic systems relate to apathy in stroke patients. This study aims to understand the brain's role in apathy to improve future treatments.

ApathyStroke>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementNeurologyPsychiatry

Heart Procedure: Beta Blocker Study

We are investigating how beta blockers may impact patients undergoing transcatheter aortic valve replacement. This study aims to understand their effects on recovery and outcomes.

Aortic Stenosis>2 yearsMonitoring phase (IV)Cardiology

Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

Severe Acute Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Colon Cancer: Chemotherapy Study for Older Adults

We are comparing two chemotherapy strategies for patients aged 70 and older who have had surgery for stage III colon cancer. The goal is to see which treatment helps prevent cancer from returning.

Colon Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Non-Small Cell Lung Cancer: New Treatment Study

We are testing new investigational treatments for patients with previously treated stage IV non-small cell lung cancer. The study aims to evaluate how well these treatments work and their safety.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Cancer Detection: 68Ga-FAPI PET/CT Imaging Study

We are studying a new imaging method for patients with unclear cancer diagnoses from standard tests. The goal is to see if this new method can provide clearer results and improve diagnosis accuracy.

Suspicion of Cancer or New Tumor Diagnosis>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Patritumab Deruxtecan for Pediatric Solid Tumors

We are studying a new treatment for children with relapsed or refractory solid tumors to see if it is safe and effective. This trial aims to understand how well it works compared to existing options.

HepatoblastomaRhabdomyosarcoma>2 yearsSafety phase (I)Efficacy phase (II)Investigational MedicinesCost ReimbursementOncologyPediatrics

Rheumatoid Arthritis: Prednisolone Tapering Strategies

We are studying whether a quick reduction of low-dose Prednisolone is as effective as a slower taper for newly diagnosed rheumatoid arthritis patients. The goal is to see how these approaches affect pain, function, and overall health.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Indocyanine Green in Gynecological Cancer Surgery

We are testing a dye to improve blood flow assessment during surgery for patients with recurrent gynecological cancer. This study aims to see if it helps reduce complications and improve surgical outcomes.

Gynecological CancersPelvic Exenteration>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Refractory B Cell Autoimmune Diseases: CNTY-101 Treatment

We are testing CNTY-101, a new cell therapy, for people with hard-to-treat B cell autoimmune diseases. The goal is to see if it can improve their condition compared to standard treatments.

Systemic Lupus Erythematosus and Related Conditions>2 yearsSafety phase (I)DermatologyInfectious DiseasesRheumatology

Antibiotics in Children with Brain Tumors

We are studying how different antibiotics move into the cerebrospinal fluid of children with malignant brain tumors. This research may help improve treatment for infections in these patients.

Brain Tumors>2 yearsSafety phase (I)No PlaceboStandard MedicinesInfectious DiseasesOncologyPediatrics

Advanced Non-Small Cell Lung Cancer: Cemiplimab Treatment Study

We are investigating whether treatment decisions based on blood tests for tumor DNA improve outcomes for patients with advanced non-small cell lung cancer. This includes testing Cemiplimab alone or with chemotherapy.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology