Search Clinical Trials in the European Union

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161-180 of 552 trials

Pulmonary Embolism: Surveillance vs. Anticoagulation

We are studying whether monitoring without blood thinners is as safe and effective as using them for low-risk patients with isolated subsegmental pulmonary embolism. This trial will also assess side effects and quality of life for participants.

Isolated Subsegmental Pulmonary Embolism3-6 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesPartially RemoteCardiologyPulmonology

Cardiac Anesthesia: Eleveld Model for Propofol and Remifentanil

We are studying how well a new model predicts drug levels of propofol and remifentanil in patients undergoing heart surgery. This research may help improve anesthesia safety and effectiveness during cardiac procedures.

Heart Disorders1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal MedicineOtolaryngology

Pancreatic Exocrine Insufficiency: Creon® Therapy Study

We are exploring how Creon® may help improve nutrition and quality of life for patients with pancreatic exocrine insufficiency after total gastrectomy. The study also looks at weight changes and gastrointestinal symptoms.

Pancreatic Exocrine Insufficiency1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Hormonal Contraceptives: Brain Effects Study

We are comparing two types of hormonal contraceptives to see how they affect brain structure and function. We're also looking at their impact on quality of life and mental health symptoms.

Hormonal Contraception≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsNeurology

ANCA-Associated Vasculitis: Rituximab with Cyclophosphamide

We are studying the effects of combining rituximab with cyclophosphamide compared to rituximab alone in patients with ANCA-associated vasculitis. This research aims to find out how these treatments help maintain remission and their impact on patient health.

ANCA Vasculitis>2 yearsMonitoring phase (IV)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementRheumatology

Mpox Vaccination Study: MPOX-VAX

We are studying a vaccine to see how well it prevents Mpox infection and how long the immune response lasts. Participants will also be monitored for other infections to understand overall health impacts.

Mpox Infection6-12 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious Diseases

Pompe Disease: Enzyme Replacement Therapy Study

We are examining how a new enzyme replacement therapy affects muscle glycogen in people with Pompe disease who have not yet received treatment. This research may help improve future therapies for this condition.

Pompe's Disease>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyHematologyNeurology

Eosinophilic Granulomatosis with Polyangiitis: Mepolizumab Treatment

We are studying how mepolizumab affects the nasal microbiome and immune response in patients with eGPA. This research may help understand its impact on local inflammation in the ENT area.

Eosinophilic Granulomatosis with Polyangiitis (eGPA)>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOtolaryngology

Dupilumab for Chronic Rhinosinusitis with Nasal Polyps

We are studying how dupilumab affects ear symptoms and hearing in patients with chronic rhinosinusitis and eosinophilic otitis media. This research aims to improve understanding of treatment benefits for these conditions.

Chronic Rhinosinusitis with Nasal PolypsEosinophilic Otitis Media>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyOtolaryngology

CRSwNP: Predicting Response to Mepolizumab

We are studying biomarkers to see if they can help predict how well patients with CRSwNP respond to the treatment mepolizumab. This research aims to improve personalized treatment options for these patients.

Chronic Rhinosinusitis with Nasal Polyps≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyOtolaryngology

Intrathecal Baclofen for Spinal Cord Injury: Safety Study

We are investigating whether intrathecal baclofen is safe for spinal cord injury patients, particularly regarding lung function and sleep disorders. The study also looks at its potential to reduce muscle stiffness and improve daily activities.

Spinal Cord Injury>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurologyPulmonology

Thrombosis Prevention in Surgery: Apixaban Study

We are studying whether the medication apixaban can help prevent blood clots in patients undergoing general abdominal, gynecologic, and urologic surgeries. This trial compares its effects to not using any anticoagulants during surgery.

Venous Thromboembolism>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteGynecology and ObstetricsInternal MedicineOrthopedics and TraumatologyUrology

Crohn's Disease: Vedolizumab vs. Adalimumab Dose Increase

We are studying whether Vedolizumab is more effective than increasing the dose of Adalimumab for Crohn's disease patients who are not responding well to their current treatment. This trial will help us understand which strategy leads to better remission and fewer side effects.

Crohn's Disease3-6 monthsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Roxadustat: Impact on Heart and Metabolism

We are investigating how roxadustat influences glucose and fat metabolism and heart function in participants. This study may help us understand its potential benefits for cardiovascular health.

Risk Factors for Cardiovascular DiseaseMetabolic Syndrome1-2 yearsMonitoring phase (IV)Standard MedicinesCardiologyEndocrinologyInternal Medicine

Meniscal Loss: Spongioflex® Allografts Study

We are investigating whether sterile allogeneic spongioflex® allografts can improve knee function in patients with incomplete meniscal loss. The study will also assess safety and patient satisfaction over several years.

Meniscus Tear>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOrthopedics and Traumatology

Liver Tumors: Indocyanine Green for Better Detection

We are testing whether a dye can help surgeons find liver tumors more easily during surgery. This study aims to improve surgical outcomes and understand how the dye behaves in the liver.

Resectable Malignant Liver Tumor>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteHepatologyOncology

Whooping Cough Vaccine: Tdap-IPV Study

We are studying whether a booster shot of the Tdap-IPV vaccine helps prevent colonization by whooping cough bacteria in healthy adults after exposure. This research aims to improve vaccination strategies against whooping cough.

Whooping Cough≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious Diseases

Chronic Pelvic Pain: Esketamine Infusion Study

We are investigating whether an 8-hour infusion of esketamine can help reduce chronic pelvic pain in individuals with endometriosis. The study also examines treatment experiences and overall quality of life.

EndometriosisMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsPsychiatry

Stroke Treatment Study: Tirofiban vs. Aspirin

We are comparing the effectiveness and safety of tirofiban and aspirin for patients with acute ischemic stroke caused by tandem lesions. This study aims to find out which treatment better prevents complications and improves recovery.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyNeurology

Coronary Artery Disease: Comparing Diabetes Medications

We are studying how well a new diabetes medication works to improve heart health in people with coronary artery disease and prediabetes. This trial compares a GLP-1 agonist and an SGLT-2 inhibitor to standard treatment.

Coronary Artery DiseasePrediabetesCoronary Atherosclerosis3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyEndocrinology