Search Clinical Trials in the European Union

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1761-1780 of 2,251 trials

Immunotherapy for Cutaneous Squamous Cell Carcinoma

We are studying whether immunotherapy can help patients with skin cancer achieve remission without surgery or radiation. This trial aims to assess the treatment's effectiveness and safety over time.

Skin Cancer (Cutaneous Squamous Cell Carcinoma)>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesDermatologyOncology

Neuroendocrine Neoplasms: Advanced PET/CT Imaging Study

We are exploring how combined PET/CT scans can help predict survival outcomes for patients with neuroendocrine neoplasms. This study may also identify who is eligible for targeted therapies based on imaging results.

Neuroendocrine Carcinoma1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesEndocrinologyOncology

Recurrent Brain Tumors in Children: Ultrasound Blood-Brain Barrier Study

We are evaluating a new ultrasound device to safely open the blood-brain barrier before chemotherapy in children with recurrent brain tumors. This study aims to see how well this method works and its effects on tumor progression.

Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesNeurologyOncologyPediatrics

COPD Management: Azithromycin Based on Mucus Properties

We are studying whether prescribing azithromycin based on mucus rheology helps reduce COPD flare-ups compared to standard treatment. This trial aims to improve care for patients with chronic airway disease.

Chronic Obstructive Pulmonary Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicinePulmonology

Early Breast Cancer: Trastuzumab-Deruxtecan vs. Standard Care

We are studying a new treatment for early breast cancer patients who have had a molecular relapse. The trial aims to see if this new therapy clears cancer markers more effectively than standard treatments.

HER2-positive Breast CancerBreast Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Metastatic Colorectal Cancer: S 95005 with Bevacizumab

We are studying a new treatment combination for patients with metastatic colorectal cancer who cannot receive intensive therapy. The goal is to see if it helps patients live longer without disease progression compared to standard treatment.

Metastatic Colorectal Cancer1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

B-Cell Lymphoma: Valemetostat Tosylate Study

We are testing a new treatment for patients with relapsed or refractory B-cell lymphoma. The study aims to see how well it works and its safety across different lymphoma types.

Relapse/Refractory B-Cell Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Stroke Prevention: ASPIRING Study

We are investigating if an oral antiplatelet drug can help prevent serious heart and brain events in stroke survivors. This study compares the effects of this medication to standard care without antiplatelet drugs.

Intracerebral Hemorrhage>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal MedicineNeurology

Liver Transplant: QEL-001 Treatment Study

We are testing a new CAR T cell therapy for patients who received an HLA-A2 mismatched liver transplant. The goal is to evaluate its safety and how well it works in this specific group.

Liver Transplant Rejection3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHepatologyInternal Medicine

High-Risk Breast Cancer: Personalized Chemotherapy Study

We are investigating a new chemotherapy treatment for patients with high-risk, HER2-negative breast cancer to see if it improves survival rates compared to standard therapies. This trial is for individuals with specific genetic profiles, including those without known BRCA mutations.

Breast Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Intensive Care: INCEPT Trial

We are studying different treatments for adults admitted to the intensive care unit to see how they affect recovery. This trial aims to improve care by understanding the best practices among clinicians.

Intensive Care>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicineNeurologyPulmonology

Glioblastoma Multiforme: Long-Term Safety of Temferon

We are monitoring the long-term safety and effects of Temferon in patients who have been treated for glioblastoma multiforme. This study aims to understand any potential side effects and how the disease may progress.

Glioblastoma MultiformeSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteNeurologyOncology

Colorectal Cancer: Dendritic Cell Vaccine Study

We are testing a personalized vaccine made from patients' own cells after surgery for stage IV colorectal cancer. The goal is to see if it safely boosts the immune response against cancer.

Stage IV Colorectal Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesOncology

Pancreatic Cancer: Sotorasib with Chemotherapy

We are studying the safety of combining sotorasib with standard chemotherapy for patients with advanced pancreatic cancer that has a specific genetic mutation. This trial aims to see if this combination improves treatment outcomes.

Pancreatic Cancer≤3 monthsSafety phase (I)No PlaceboStandard MedicinesGastroenterologyOncology

B-Cell Malignancies: BGB-16673 Treatment Study

We are investigating the safety and effectiveness of BGB-16673 combined with other treatments for patients with relapsed or refractory B-cell malignancies. This study aims to find the best dose and assess how well the treatment works.

Relapsed or Refractory B-Cell Malignancies>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Wrist Osteoarthritis: Microfat and PRP Injection Study

We are testing whether injections of your own fat and platelet-rich plasma can help relieve pain in wrist osteoarthritis compared to standard surgery. This study aims to see if the new treatment is just as effective and safe.

Wrist Osteoarthritis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOrthopedics and TraumatologyRheumatology

Acute Demyelinating Syndromes in Children: Azathioprine vs. Rituximab

We are studying whether starting treatment immediately with azathioprine or rituximab helps children with anti-MOG antibodies better than delaying treatment until a second attack. The goal is to see which method reduces relapses and improves health outcomes.

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyRheumatology

Hereditary Angioedema: Deucrictibant Extended-Release Tablet

We are studying a new oral medication to prevent angioedema attacks in adolescents and adults with hereditary angioedema. The trial will evaluate its safety, effectiveness, and impact on quality of life.

Hereditary Angioedema>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyInternal Medicine

Iron Deficiency Anemia in Children: Ferumoxytol Study

We are testing the safety and effectiveness of the drug ferumoxytol for children with iron deficiency anemia. This study compares it to an existing treatment to see how well it works.

Iron Deficiency Anemia≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesHematologyPediatrics

Fertility Preservation for Breast Cancer: Tamoxifen and Ovarian Stimulation

We are studying whether combining Tamoxifen with ovarian stimulation can help women with breast cancer collect healthy eggs before chemotherapy. This may support their chances of having children in the future.

Breast CancerEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology