Search Clinical Trials in the European Union

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321-340 of 2,120 trials

Graft-versus-Host Disease: MC0518 Treatment for Kids

We are studying a new treatment called MC0518 for children with steroid-refractory acute graft-versus-host disease after stem cell transplant. The goal is to see if it works better than the best available therapy.

Steroid Refractory Acute Graft Versus Host Disease>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesHematologyInfectious Diseases

Anifrolumab for Polymyositis and Dermatomyositis

We are studying whether Anifrolumab can improve muscle strength and reduce corticosteroid use in adults with polymyositis and dermatomyositis compared to a placebo.

Polymyositis and Dermatomyositis>2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteInfectious DiseasesRheumatology

Breast Cancer Surgery: ICG Imaging Study

We are exploring how a special imaging technique using ICG dye can help surgeons evaluate cancer margins during breast-conserving surgery. This study aims to find the best timing and dose for the dye to improve surgical outcomes.

Early Invasive Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

[18F]PSMA-1007 PET/CT Imaging for Prostate Cancer

We are studying how well a new imaging method detects cancer spread in patients with newly diagnosed high-risk prostate cancer. This could help improve diagnosis and treatment planning.

Prostate Cancer>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Guselkumab for Crohn's Disease Healing

We are studying whether guselkumab can help heal the intestinal wall in patients with Crohn's disease. This research aims to find out how effective it is over 48 weeks.

Crohn's Disease>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Hip Replacement Pain Management: Néfopam Study

We are studying the effects of néfopam on pain relief after hip replacement surgery. This trial compares its use against a placebo to see if it helps reduce the need for morphine and improves recovery.

Hip Replacement Surgery6-12 monthsConfirmation phase (III)Standard MedicinesInternal MedicineOrthopedics and Traumatology

Hunter Syndrome: Long-Term Safety of Idursulfase-IT and Elaprase®

We are studying the long-term safety of a treatment combining intrathecal idursulfase-IT and intravenous Elaprase® for individuals with Hunter syndrome and cognitive impairment. This research aims to ensure the safety of these therapies over time.

Hunter's SyndromeConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyInternal MedicineNeurology

Breast Cancer: Stopping CDK4/6 Inhibitors

We are studying whether stopping CDK4/6 inhibitors helps maintain disease stability in patients with metastatic HR positive, HER2 negative breast cancer. This trial involves patients who have had stable disease after long-term treatment.

Metastatic HR Positive, HER2 Negative Breast Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

HER2-Negative Breast Cancer: Pembrolizumab and Radiation Therapy

We are studying a new treatment combining immunotherapy and radiation for patients with HER2-negative breast cancer who haven't responded to initial chemotherapy. The goal is to see if this approach improves cancer response and quality of life.

HER2 Negative Breast Cancer>2 yearsEfficacy phase (II)Standard MedicinesOncology

Endometrial Cancer: NEPA for Nausea Relief

We are studying whether a single dose of NEPA can effectively prevent nausea and vomiting in patients with endometrial cancer receiving chemotherapy. This trial also assesses the safety of NEPA and its effects on patients' quality of life.

Chemotherapy-Induced Nausea and Vomiting Prophylaxis≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOncology

Nipocalimab for Generalized Myasthenia Gravis

We are studying whether nipocalimab IV infusions can help adults with generalized myasthenia gravis perform daily activities better than a placebo. This research aims to assess its effectiveness and safety.

Myasthenia Gravis6-12 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Advanced Ovarian Cancer: Comparing Treatment Combinations

We are studying two different drug combinations to see which one helps patients with advanced ovarian cancer live longer without disease progression after surgery. This trial involves patients who have undergone complete initial surgery.

Advanced Ovarian Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Atopic Eczema: Dupilumab Dosing Study

We are studying how different dosing schedules of dupilumab affect people with controlled atopic eczema. The goal is to see which schedule works best for managing symptoms and improving quality of life.

Atopic Eczema3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteAllergologyDermatology

Advanced Breast Cancer: Saruparib and Camizestrant Study

We are studying a new combination treatment for adults with advanced hormone receptor-positive, HER2-negative breast cancer. The goal is to see if it helps patients live longer without disease progression compared to standard therapies.

Advanced Breast CancerConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyOncology

Fertility Treatment: Natural Progesterone vs. GnRH Antagonists

We are comparing a natural progesterone treatment to a standard injectable medication for women undergoing ovarian stimulation. The goal is to see which method is more effective and cost-efficient in preventing hormonal surges.

Women Undergoing Ovarian Stimulation for Oocyte DonationMonitoring phase (IV)No PlaceboInvestigational MedicinesGynecology and Obstetrics

Metastatic Melanoma: Diclofenac with PD-1 Inhibitor

We are studying whether adding diclofenac to ongoing PD-1 inhibitor therapy helps patients with metastatic melanoma who have stable disease. This trial aims to evaluate the potential benefits of this combination treatment.

Metastatic Melanoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesDermatologyOncology

Long-Term Follow-Up for Gene-Modified T Cell Treatment

We are monitoring patients treated with gene-modified T cells to assess any delayed side effects and the long-term effectiveness of the treatment. This study also looks at the health of younger patients who received this therapy.

Malignant Lymphoid Neoplasm>2 yearsEfficacy phase (II)Confirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteHematologyInternal MedicineOncology

Lumbar Spinal Surgery: Erector Spinae Plane Block

We are studying whether a specific pain management technique can reduce the need for morphine after lumbar spinal surgery. We will also look at recovery quality and any complications related to the procedure.

Patients Undergoing Lumbar ArthrodesisMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

Heart Procedure: Protamine Administration Study

We are comparing routine versus selective use of protamine during transcatheter aortic valve implantation to see which method better reduces bleeding and death risks after the procedure.

Aortic Stenosis≤3 monthsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesCardiologyInternal Medicine

Community-Acquired Pneumonia: Customized Antibiotic Duration Study

We are investigating whether a new strategy for shortening antibiotic treatment is as effective as standard care for hospitalized patients with pneumonia. This study aims to improve patient outcomes while reducing unnecessary antibiotic use.

Community-acquired Pneumonia>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesInternal MedicinePulmonology