Search Clinical Trials in the European Union

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541-560 of 2,120 trials

HMB-001 for Glanzmann Thrombasthenia

We are investigating a new treatment to see if it is safe and can help reduce bleeding in people with Glanzmann Thrombasthenia. This study will also look at how the body processes the medication and its effects on quality of life.

Glanzmann's Disease1-2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematology

Juvenile Psoriatic Arthritis: Risankizumab Study

We are studying a new treatment called risankizumab for children aged 5 to 17 with active juvenile psoriatic arthritis. The goal is to see if it is safe and effective compared to an existing medication.

Juvenile Psoriatic Arthritis>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementDermatologyPediatricsRheumatology

Myotonic Dystrophy Type 1: VX-670 Study

We are testing the safety and tolerability of a new drug, VX-670, in adults with myotonic dystrophy type 1. This study aims to understand how the drug works in the body and its potential benefits.

Myotonic DystrophySafety phase (I)Efficacy phase (II)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Hypertonic Lactate After Cardiac Arrest: The LATTE Trial

We are studying whether hypertonic sodium lactate can help reduce brain injury in comatose survivors of cardiac arrest. This trial will also look at its effects on recovery and safety.

Cardiac ArrestComaPost Cardiac Arrest Syndrome≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesCardiologyNeurology

Follicular Lymphoma: Mosunetuzumab and Zanubrutinib Study

We are investigating a combination of two medications for patients with relapsed or refractory follicular lymphoma. The goal is to see if this treatment improves outcomes and safety compared to existing options.

Follicular Lymphoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematology

Ketamine for Depression and Alcohol Use Disorder

We are studying whether ketamine can help adults with depression and alcohol use disorder during their addiction treatment. The trial will also look at the safety of this treatment approach.

DepressionAlcohol Use Disorder6-12 monthsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemotePsychiatry

Pain Management: Dexmedetomidine for Nerve Block

We are exploring the best dose of dexmedetomidine to enhance pain relief during a nerve block procedure. This study will also check for side effects and benefits like reduced opioid use and better patient satisfaction.

Patients Scheduled for Shoulder Operations1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOrthopedics and TraumatologyOtolaryngology

EPO-TRAUMA: Epoetin Alfa for Critically Ill Trauma Patients

We are studying whether epoetin alfa can lower the risk of death and severe disability in critically ill patients after trauma. This trial compares its effects to a placebo treatment.

Traumatic Injury3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicinePulmonology

Achondroplasia: TransCon CNP Treatment for Infants

We are investigating the safety and growth effects of weekly injections of TransCon CNP in infants with achondroplasia. This study aims to understand how the treatment may help with growth and development.

Achondroplasia1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementEndocrinologyPediatrics

Gastric Cancer: Dostarlimab Immunotherapy Study

We are exploring a new treatment approach for patients with localized gastric cancer to see if delaying surgery while using Dostarlimab can be effective. The study aims to evaluate patient responses and safety over time.

Metastatic Gastric Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGastroenterologyOncology

Weight Management in Schizophrenia: Semaglutide Study

We are investigating whether semaglutide can help patients with schizophrenia and obesity improve their weight and metabolic health. This study compares semaglutide to a placebo to see its effects on various health measures.

Metabolic Control in Antipsychotic-Using Patients6-12 monthsConfirmation phase (III)>20 visitsInvestigational MedicinesEndocrinologyPsychiatry

Colorectal Cancer: Reduced Dose Chemotherapy for Older Patients

We are studying whether a lower dose of chemotherapy is as effective as the standard dose for older patients with advanced colorectal cancer. This may help improve quality of life and reduce severe side effects.

Metastatic Colorectal Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Breast Reconstruction: Goal-Directed Fluid Therapy

We are studying how a specific fluid management approach during DIEP breast reconstruction may reduce swelling and improve healing. This trial aims to see if it helps with better blood flow to the surgical area.

Low Blood Pressure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal MedicineOtolaryngology

Efgartigimod PH20 SC for Children with Generalized Myasthenia Gravis

We are studying a new treatment for children aged 2 to under 18 with generalized myasthenia gravis. The trial will help us understand the right dose and evaluate its safety and effects on daily life.

Myasthenia Gravis3-6 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Atopic Dermatitis: Personalized Treatment Approaches

We are studying how genetic and biochemical markers can help choose the best treatment for patients with atopic dermatitis needing stronger therapies. This research may lead to better management strategies tailored to individual needs.

Atopic Dermatitis6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesAllergologyDermatology

VAXXAIR TRIAL: Comparing Nasal and Injectable Flu Vaccines

We are studying how well a nasal flu vaccine works compared to an injectable one in building immunity. This research aims to find out which method produces a stronger immune response in the body.

Influenza>2 yearsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPulmonology

Neonatal OTC Deficiency: ECUR-506 Treatment Study

We are investigating a new treatment called ECUR-506 for boys under 9 months with neonatal onset OTC deficiency. The study will help us understand its safety and how well it works.

Ornithine Transcarbamylase Deficiency6-12 monthsSafety phase (I)Efficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicinePediatrics

Chronic Spontaneous Urticaria: Omalizumab Treatment Intervals

We are studying whether adults with well-controlled chronic spontaneous urticaria can safely extend the time between omalizumab treatments while maintaining symptom control.

Chronic Spontaneous Urticaria6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteAllergologyDermatology

Colorectal Liver Metastases: HAIP-SYST Treatment Study

We are investigating a new combination of local and systemic chemotherapy for patients with initially unresectable colorectal liver metastases. The study aims to see if this approach improves survival and quality of life compared to standard treatment.

Colorectal Liver Metastases1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesHepatologyOncology

Diffuse Large B-cell Lymphoma: Rituximab and Golcadomide Study

We are testing a new combination treatment for older frail patients with Diffuse Large B-cell non-Hodgkin Lymphoma. This study aims to see if it can improve outcomes without traditional chemotherapy.

Diffuse Large B-cell Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesHematologyInternal Medicine