Search Clinical Trials in the European Union

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821-840 of 1,782 trials

Hallux Valgus Surgery: Ropivacaine Ankle Block Study

We are investigating how different strengths of ropivacaine affect pain relief and recovery in patients undergoing hallux valgus repair surgery. This study aims to find the best concentration for effective anesthesia and reduced opioid use.

Bunion (Hallux Valgus)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOrthopedics and TraumatologyOtolaryngology

High-Risk Medulloblastoma: New Treatment Approaches

We are exploring whether new radiotherapy and chemotherapy methods improve outcomes for children and adults with high-risk medulloblastoma. The study also looks at the long-term effects of these treatments on patients' health and quality of life.

Medulloblastoma6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncologyPediatrics

Rhabdomyosarcoma: New Treatment Combinations

We are studying new chemotherapy and radiotherapy options for children and adults with Rhabdomyosarcoma. The goal is to see if these new treatments improve outcomes compared to standard therapies.

RhabdomyosarcomaSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncologyPediatrics

Ovarian Cancer: 5-ALA Imaging Study

We are testing a dye called 5-ALA to see if it helps surgeons find ovarian cancer tumors that regular methods might miss. This study aims to improve tumor detection during surgery.

Ovarian Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsOncologyOtolaryngology

Kidney Transplant Rejection: INTERCEPT Study

We are studying whether adding TCZ to standard treatment helps kidney transplant recipients with chronic rejection maintain better kidney function. The trial also looks at the safety of this treatment and its effects on overall health.

Chronic Active Antibody-Mediated Rejection>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteInternal MedicineNephrology

Glioma Treatment Study: Temozolomide and Lomustine

We are testing a combination of chemotherapy and radiotherapy for patients with newly diagnosed grade 2 or 3 glioma. The goal is to see if this approach improves survival compared to standard treatments.

Newly Diagnosed Glioma>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurologyOncology

Parkinson's Disease: New Approaches to Levodopa Resistance

We are studying whether the medication apomorphine or the antibiotic rifaximin can help people with Parkinson's disease who struggle with levodopa treatment. This trial aims to improve their symptoms and overall treatment response.

Parkinson's Disease6-12 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementInternal MedicineNeurology

Denosumab: Impact on Muscle Strength and Insulin Sensitivity

We are studying whether denosumab can improve muscle strength and insulin sensitivity in participants. This trial compares its effects to a placebo to understand its potential benefits.

Diabetes MellitusPostmenopausal Osteoporosis6-12 monthsMonitoring phase (IV)Standard MedicinesEndocrinologyHepatologyInternal Medicine

Acute Myeloid Leukemia: Venetoclax and Azacitidine Treatment

We are studying whether a combination of venetoclax and azacitidine can help clear residual disease in AML patients before a stem cell transplant. This trial also looks at the safety and effectiveness of this treatment approach.

Acute Myeloid Leukemia>2 yearsEfficacy phase (II)Confirmation phase (III)>20 visitsNo PlaceboStandard MedicinesHematologyOncology

Soft Tissue Sarcoma: Oral Cyclophosphamide vs Doxorubicin

We are comparing the effectiveness of oral cyclophosphamide and doxorubicin in treating elderly patients with advanced soft tissue sarcoma. The goal is to find out which treatment may lead to better outcomes and fewer side effects.

Soft Tissue SarcomaConfirmation phase (III)No PlaceboStandard MedicinesOncology

Chronic Migraine: Eptinezumab for Teens

We are studying whether eptinezumab can help reduce the number of migraine days in adolescents aged 12 to 17 with chronic migraine. This trial compares the medication to a placebo to assess its effectiveness.

Migraine3-6 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteNeurologyPediatrics

Zanamivir for Infants with Complicated Influenza

We are studying how safe and effective intravenous zanamivir is for hospitalized infants under 6 months with complicated influenza. This research aims to understand how the drug works in young children.

Human Influenza>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesPediatrics

Andersen-Tawil Syndrome: Flecainide Therapy Study

We are exploring whether flecainide alone or in combination with other medications is more effective for managing heart rhythm issues in patients with Andersen-Tawil syndrome and multifocal ectopic contractions.

Andersen-Tawil SyndromeMultifocal Ectopic Purkinje-related Premature Contractions≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiology

Mpox Booster Vaccine: Fractional vs. Full Dose

We are studying whether a smaller booster dose of the MVA-BN vaccine is as effective as the standard dose in adults. This trial will also look at the safety and immune response of both doses.

Mpox (Monkeypox)3-6 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious Diseases

External Cephalic Version: Propofol vs. Spinal Analgesia

We are comparing the use of Propofol and spinal analgesia for sedation during a procedure to turn breech babies. Our goal is to find out which method has a higher success rate and fewer complications.

External Cephalic Version>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Prostate Cancer: Personalized Radiotherapy and Hormone Therapy

We are studying whether using AI to customize radiotherapy and hormone treatment can help prostate cancer patients while reducing the overall treatment time. This trial is for those with high-risk localized prostate cancer.

Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Soft Tissue Sarcoma: MEK and PDL1 Inhibitor Combination

We are studying a new treatment combining two medications for patients with advanced soft tissue sarcoma. This trial aims to confirm safety and evaluate how well the treatment works in both children and adults.

Advanced or Metastatic CancerSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

Soft Tissue Sarcomas: Atezolizumab with Radiotherapy

We are studying whether adding an immunotherapy drug to radiotherapy helps patients with localized soft tissue sarcomas achieve better treatment outcomes. The trial will also look at the safety and immune response to this combination.

Localized Soft Tissue Sarcoma3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncology

VEXAS Syndrome: Azacitidine Treatment Study

We are studying whether Azacitidine can help reduce symptoms and improve health in patients with VEXAS Syndrome. The trial will also assess the safety of this treatment and its impact on patients' quality of life.

VEXAS Syndrome>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteHematologyRheumatology

Membranous Nephropathy: Personalized Rituximab Treatment Study

We are exploring whether an AI-driven personalized treatment plan for membranous nephropathy is more effective than standard rituximab treatment. This study aims to improve patient outcomes and remission rates.

Acute GlomerulonephritisMembranous Nephropathy6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesNephrology