Search Clinical Trials in the European Union

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901-920 of 1,782 trials

RECLAIM: Treatments for Long COVID

We are studying different treatments for people suffering from long COVID to see how they improve physical and mental health. The trial will also assess specific symptoms like fatigue and cognitive difficulties.

Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)3-6 monthsConfirmation phase (III)6-10 visitsStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Atrial Fibrillation After Aortic Valve Surgery: Atorvastatin Study

We are investigating whether taking atorvastatin before surgery helps reduce the risk of atrial fibrillation in patients undergoing aortic valve replacement. We also want to see how stopping statins affects complications after surgery.

Atrial Fibrillation and FlutterPatients Undergoing Surgical Aortic Valve Replacement≤3 monthsMonitoring phase (IV)Standard MedicinesCardiology

Locally-Advanced Rectal Cancer: Tailored Treatment Study

We are studying a personalized treatment plan for patients with locally-advanced rectal cancer who respond well to initial chemotherapy. The goal is to see if this approach maintains effective surgery outcomes while reducing treatment intensity.

Rectal Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Alzheimer's Disease: Understanding Tau Spread and Language Function

We are studying how tau protein spreads in the brain during different stages of Alzheimer's disease and its impact on language abilities. This research may help us understand cognitive changes in patients.

Early Alzheimer's Disease>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesNeurologyPsychiatry

Esophageal Adenocarcinoma: Metformin Treatment

We are studying whether metformin can enhance the immune response in patients with esophageal adenocarcinoma receiving chemoradiotherapy. This research may help improve treatment effectiveness and patient outcomes.

Oesophageal Adenocarcinoma3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyOncology

Daratumumab for Very High-Risk T-Cell Acute Lymphoblastic Leukemia

We are studying whether adding daratumumab to standard treatment helps adults with very high-risk T-ALL achieve better disease control. This trial will also assess the safety and effectiveness of this combination therapy.

Very High-Risk T-Lineage Acute Lymphoblastic Leukemia>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Hodgkin's Lymphoma: Atezolizumab and BEGEV Treatment

We are studying a new combination treatment for patients with relapsed or refractory Hodgkin's lymphoma to see if it helps improve response rates before stem-cell transplantation. This trial will also evaluate the safety and tolerability of this treatment approach.

Hodgkin's Lymphoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Mantle Cell Lymphoma: Loncastuximab Tesirine Treatment

We are studying whether loncastuximab tesirine can improve outcomes for patients with relapsed or refractory mantle cell lymphoma after immunochemotherapy. The trial also looks at the safety of this treatment and its effectiveness in reducing disease presence.

Mantle Cell LymphomaEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Plasmablastic Lymphoma: Daratumumab with Bortezomib and Dexamethasone

We are studying a combination of daratumumab, bortezomib, and dexamethasone for patients with relapsed or refractory plasmablastic lymphoma. The goal is to see if this treatment improves outcomes for those who cannot undergo stem cell transplantation.

Relapsed or Refractory Plasmablastic Lymphoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Myelodysplastic Syndrome: Targeted Treatment After Stem Cell Transplant

We are studying a new approach to prevent relapse and improve survival in patients with myelodysplastic syndrome after stem cell transplantation. The trial focuses on those with minimal residual disease to see if personalized treatment can help.

Myelodysplastic Syndrome>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Prostate Cancer: Radium-223 and Docetaxel Study

We are exploring whether using Radium-223 followed by Docetaxel helps men with bone-only metastatic prostate cancer feel better and live longer. This study will compare the effects of these treatments on quality of life and survival.

Metastatic Castration-Resistant Prostate CancerSymptomatic Bone-Only Metastatic Castration-Resistant Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

NVDX3 Implant: Long-Term Safety Study

We are examining the long-term safety of the NVDX3 osteogenic implant made from human tissue. This study aims to ensure it is safe for patients who may need this type of treatment.

Low Grade Degenerative Lumbar SpondylolisthesisDistal Radius Fracture>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOrthopedics and Traumatology

Cirrhosis: Carvedilol for Prevention

We are studying whether low-dose carvedilol can help prevent complications or death in patients with asymptomatic cirrhosis. This trial focuses on individuals with specific liver conditions to see if the medication is effective and safe.

Alcoholic Cirrhosis>2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementHepatologyInternal Medicine

Anorexia Nervosa: Donepezil Treatment Study

We are investigating whether donepezil can help improve symptoms and support weight gain in adult women with anorexia nervosa. This study compares its effects to a placebo to understand its potential benefits.

Anorexia Nervosa3-6 monthsEfficacy phase (II)Standard MedicinesPsychiatry

Long-term Safety of Genetically Modified T Cell Therapy

We are following up with patients who received genetically modified T cells to assess their long-term safety and survival. This study aims to understand how well the treatment works and any potential risks involved.

Acute Lymphoblastic LeukemiaSystemic Lupus ErythematosusNon-Hodgkin's Lymphoma>2 yearsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyOncologyRheumatology

Dexamethasone for Congenital Adrenal Hyperplasia in Pregnancy

We are studying whether a lower dose of dexamethasone can effectively prevent prenatal complications in female babies with congenital adrenal hyperplasia. We will also monitor the health of mothers and their children during and after pregnancy.

Congenital Adrenal HyperplasiaEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and Obstetrics

High Blood Pressure: Irbesartan and Amlodipine Combination

We are testing a new fixed-dose pill combining irbesartan and amlodipine for patients with high blood pressure. The goal is to see if it effectively lowers blood pressure and is safe for use.

High Blood Pressure1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Stage III Lung Cancer: Surgery and Durvalumab Study

We are exploring whether surgery is safe for patients with initially unresectable stage III lung cancer after high-dose treatment. We also want to see if they can benefit from a follow-up therapy called durvalumab.

Stage III Non-Small Cell Lung CancerMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Enterococcus faecalis Endocarditis: Continuous Infusion Antibiotics Study

We are studying whether continuous infusion of ampicillin and ceftriaxone is as effective as standard treatment for patients with Enterococcus faecalis infective endocarditis. This may help improve treatment outcomes and reduce complications.

Enterococcal Endocarditis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious Diseases

Adnexal Torsion: Contrast-Enhanced Ultrasound Study

We are testing a new ultrasound method to see if it helps diagnose adnexal torsion more accurately than standard methods. This could reduce unnecessary surgeries and improve care for patients with suspected torsion.

Adnexal Torsion>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsInternal Medicine