Search Clinical Trials in the European Union

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1541-1560 of 1,782 trials

Metastatic Colorectal Cancer: Choosing Chemotherapy

We are exploring a new approach to select between two chemotherapy options for patients with metastatic colorectal cancer. This study will help us understand how well these treatments work and their potential side effects.

MSS/pMMR Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Endoscopic Sleeve Gastroplasty: Impact of Proton Pump Inhibitors

We are studying how proton pump inhibitors affect the success of endoscopic sleeve gastroplasty in people seeking weight loss. We also want to learn about their effects on quality of life and metabolic health.

Obesity1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Dexamethasone for Severe Burns

We are studying whether early treatment with dexamethasone can help reduce serious complications and death in patients with severe burns. This trial will also look at its effects on infections and recovery times.

Severe Burns3-6 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Tacrolimus Monotherapy for Elderly Kidney Transplant Recipients

We are studying whether using tacrolimus alone can reduce infection risks and improve quality of life for elderly patients after a kidney transplant. This trial compares it to the standard triple medication regimen.

Kidney Transplant Complications>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineNephrology

Pancreatic Head Cancer: Neoadjuvant Chemotherapy Study

We are exploring whether giving chemotherapy before surgery helps improve survival for patients with resectable pancreatic head cancer compared to surgery alone. This study aims to find better treatment strategies to reduce early mortality.

Resectable Pancreatic Head Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

End-of-Life Care: Midazolam and Morphine Study

We are investigating how midazolam and morphine can help relieve pain and discomfort in elderly patients during their final days. This study aims to understand the best dosing strategies and any potential side effects.

Symptom Treatment in End-of-Life Care for Geriatric Patients1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Metastatic Renal Cell Carcinoma: Immunotherapy and Tumor Treatment Study

We are studying how surgery and radiation affect survival and tumor growth in patients with metastatic renal cell carcinoma receiving immunotherapy. This trial aims to improve treatment strategies and quality of life for these patients.

Advanced Kidney Cancer1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Cisternal Lavage Therapy for Aneurysmal Subarachnoid Hemorrhage

We are studying a new treatment using Urokinase and Nimodipine for patients with aneurysmal subarachnoid hemorrhage. The aim is to see if this therapy improves brain function and is safe.

Aneurysmal Subarachnoid Hemorrhage≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesNeurology

Hemophilia A: Efanesoctocog Alfa Treatment Study

We are studying the long-term effects of efanesoctocog alfa on joint health in people with hemophilia A. The trial aims to see how well it prevents joint bleeds and improves quality of life.

Haemophilia A1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOrthopedics and Traumatology

Advanced Non-Small Cell Lung Cancer: M9140 Treatment Study

We are studying a new drug called M9140 for people with advanced non-small cell lung cancer. The goal is to see how well it works and how safe it is compared to existing treatments.

Non-Small Cell Lung Cancer6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Advanced Pancreatic Cancer: M9140 Treatment Study

We are studying a new drug called M9140 for people with advanced pancreatic cancer to see how well it works and how safe it is. This trial aims to evaluate its effectiveness and side effects compared to standard treatments.

Metastatic Pancreatic Cancer6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Cystic Fibrosis: Inhaled Teicoplanin Study

We are evaluating the safety and tolerability of inhaled Teicoplanin for cystic fibrosis patients with persistent Staphylococcus aureus infections. The study aims to see if it can improve lung function and reduce infection levels.

Cystic Fibrosis with Staphylococcus Aureus Infection1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Graves' Ophthalmopathy: Diclofenac vs. Simvastatin

We are studying whether diclofenac or simvastatin can help patients with mild to moderate Graves' ophthalmopathy. The trial aims to assess the activity of the disease and its progression to more severe forms.

Graves' Ophthalmopathy6-12 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesEndocrinologyOphthalmology

High-Risk Melanoma: Neoadjuvant Pembrolizumab Study

We are studying the effects of pembrolizumab in patients with high-risk melanoma who have no signs of spread. The goal is to see if this treatment can improve outcomes before surgery.

Melanoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Prostate Cancer: Atorvastatin Study

We are investigating whether atorvastatin can help delay prostate cancer progression in men receiving androgen deprivation therapy. This study aims to see if it can prevent the cancer from becoming resistant to treatment.

Metastatic Prostate Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesOncologyUrology

Soft Tissue Sarcoma: Pembrolizumab with Radiotherapy

We are studying whether adding pembrolizumab to radiotherapy before and after surgery helps patients with high-risk localized soft tissue sarcoma live longer without disease recurrence. This trial compares this approach to standard treatment with radiotherapy and surgery alone.

High-Risk Soft Tissue Sarcoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOrthopedics and Traumatology

ADPKD Treatment: Metformin vs. Tolvaptan

We are studying whether Metformin can effectively slow kidney function decline in adults with Autosomal Dominant Polycystic Kidney Disease compared to Tolvaptan. The trial also examines the safety and impact on kidney size and symptoms.

Autosomal Dominant Polycystic Kidney Disease>2 yearsConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Hydrocortisone Treatment in Pancreatoduodenectomy Surgery

We are studying whether hydrocortisone infusions can help reduce complications after pancreatoduodenectomy surgery. This trial compares the effects of hydrocortisone to a placebo in patients undergoing this procedure.

Pancreatic Resection>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Nephrotic Syndrome: Ketoanalogues for Muscle Preservation

We are studying a new treatment to help prevent muscle loss in patients with nephrotic syndrome. This trial will assess its safety and how it may improve overall health and quality of life.

Protein-Energy Wasting in Nephrotic Syndrome>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

ANCA-Associated Vasculitis: Rituximab Treatment Study

We are comparing a combination of rituximab and cyclophosphamide to standard treatment for achieving remission in severe ANCA-associated vasculitis. The trial also looks at how different ways of giving rituximab can help maintain remission.

ANCA-Associated Vasculitis6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineRheumatology