Search Clinical Trials in the European Union

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1621-1640 of 1,782 trials

Schizophrenia and Alcohol Use Disorder: Tirzepatide Study

We are investigating whether tirzepatide can help reduce alcohol consumption in individuals with schizophrenia and alcohol use disorder. This study compares tirzepatide to a placebo to assess its effects.

Schizophrenia and Alcohol Use Disorder6-12 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyPsychiatry

Nebivolol for High Blood Pressure in Teens

We are studying how well Nebivolol works to lower blood pressure in adolescents with hypertension. The trial will also look at the safety of this medication during treatment.

Juvenile Hypertension6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Prostate Cancer Treatment: Docetaxel vs. Androgen Receptor-targeted Agents

We are studying whether docetaxel is more effective than abiraterone or enzalutamide for men with advanced prostate cancer and specific negative prognostic factors. This research aims to improve treatment outcomes and quality of life.

Metastatic Castration-Resistant Prostate CancerMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Gastroesophageal Cancer: Sertraline with Immunochemotherapy

We are studying whether adding sertraline can enhance treatment responses in patients with advanced gastroesophageal cancer receiving immunochemotherapy. The trial also looks at safety, quality of life, and depression during treatment.

Gastroesophageal Cancer>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncologyPsychiatry

Advanced Non-Small Cell Lung Cancer: H1-Antihistamine with Immunotherapy

We are studying whether adding an H1-antihistamine to immunotherapy can improve treatment response in patients with advanced non-small cell lung cancer.

Advanced Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyPulmonology

Liraglutide: Effects on Digestion and Hunger

We are studying how liraglutide affects digestive activity and hunger in healthy volunteers. This research may help us understand its potential benefits for managing appetite.

Obesity1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesEndocrinologyGastroenterology

Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

Cholangiocarcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Idiopathic Infertility: Metformin Treatment Study

We are investigating whether metformin can improve endometrial function in women with idiopathic infertility. This study aims to explore its effects on fertility and related biological markers.

Female Infertility3-6 monthsEfficacy phase (II)Standard MedicinesEndocrinologyGynecology and Obstetrics

Acute Cholecystitis: Indocyanine Green in Surgery

We are testing whether indocyanine green can help reduce surgery time and improve safety during gallbladder removal in patients with acute cholecystitis. This study aims to enhance surgical outcomes and patient satisfaction.

Acute Cholecystitis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

MOTHER Trial: Low-Dose Morphine for Cesarean Section Pain

We are studying whether adding a low dose of morphine to standard pain management helps reduce pain after a planned cesarean section. The trial also looks at the safety for both mothers and their newborns.

Planned Caesarean Section>2 yearsMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsOtolaryngology

Prostate Cancer: HIFU and Hormone Therapy Study

We are testing a combination of high-intensity focused ultrasound and short-term hormone therapy for men with intermediate-risk localized prostate cancer. The goal is to see if this approach improves cancer control and maintains sexual and urinary functions.

Intermediate Risk Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyUrology

Heart Failure: Empagliflozin and Dapagliflozin Study

We are investigating how two medications may improve outcomes for patients hospitalized with acute heart failure. The study looks at their effects on heart function and other health indicators.

Acute Decompensated Heart Failure>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

Medication-Related Osteonecrosis of the Jaw>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

HIV-1 Reservoir Study: ITACO and ITACO-ATI

We are investigating how the HIV-1 virus behaves in patients with perinatal infections to find better treatment strategies. This study looks at the effects of temporarily stopping antiretroviral therapy and the immune responses involved.

Perinatal HIV InfectionConfirmation phase (III)No PlaceboStandard MedicinesInfectious Diseases

Anticoagulation Strategies for ECMO Support

We are comparing three blood-thinning medications to see which is safer and more effective for patients on ECMO. This study aims to reduce blood clots and bleeding risks during treatment.

Respiratory Failure and Insufficiency≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Metastatic Pancreatic Cancer: Valproic Acid and Simvastatin Study

We are studying whether adding valproic acid and simvastatin to standard chemotherapy improves treatment for patients with metastatic pancreatic cancer. This trial also looks at safety and quality of life for participants.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

Severe Acute Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPsychiatry

Kidney Transplant: SGLT2 Inhibitor Study

We are investigating whether a new oral medication can improve kidney function in non-diabetic kidney transplant recipients. The study also looks at its safety and effects on overall health compared to a placebo.

Kidney Transplant1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesInternal MedicineNephrology

Rheumatoid Arthritis: Prednisolone Tapering Strategies

We are studying whether a quick reduction of low-dose Prednisolone is as effective as a slower taper for newly diagnosed rheumatoid arthritis patients. The goal is to see how these approaches affect pain, function, and overall health.

Rheumatoid Arthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Indocyanine Green in Gynecological Cancer Surgery

We are testing a dye to improve blood flow assessment during surgery for patients with recurrent gynecological cancer. This study aims to see if it helps reduce complications and improve surgical outcomes.

Gynecological CancersPelvic Exenteration>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology