Search Clinical Trials in the European Union

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361-380 of 525 trials

Chronic Cluster Headache: Botulinum Toxin Treatment Study

We are investigating whether botulinum toxin can help people with chronic cluster headaches that haven't responded to other treatments. The study will also look at safety and how it affects headache frequency and quality of life.

Chronic Cluster Headache3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteNeurology

HPV Vaccine Study for Women with HPV 16/18

We are studying how the 9vHPV vaccine affects the infectivity of HPV in women who are positive for HPV types 16 and/or 18. The goal is to see if vaccination reduces the virus in cervical, anal, urine, vulvar, and oral samples.

Human Papillomavirus Infection>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases

Eosinophilic Esophagitis: Budesonide Dosing Study

We are comparing the effectiveness and tolerability of taking budesonide once daily versus twice daily for adults with esophagus inflammation. This study aims to see if both dosing schedules work equally well and how they affect patients' quality of life.

Eosinophilic EsophagitisConfirmation phase (III)≤5 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Kidney Transplant: IVIG for BKV Prevention

We are studying whether intravenous immunoglobulins can help prevent BKV viremia in kidney transplant recipients with low antibody levels. This research aims to improve outcomes for patients at risk of BKV-related complications.

Kidney Transplant and BKV Infection>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesNephrology

Fecal Incontinence: Botulinum Toxin Injections

We are studying how botulinum toxin injections may improve rectal movement in patients with fecal incontinence. The trial will also look at the treatment's effectiveness, quality of life, and tolerance after one month.

Fecal Incontinence>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Filgrastim for Severe Bullous Drug Eruptions

We are studying whether Filgrastim can help patients with severe drug reactions like Stevens-Johnson syndrome. The goal is to see if it slows disease progression and improves recovery compared to standard treatment alone.

Stevens Johnson SyndromeLyell Syndrome>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsInvestigational MedicinesDermatology

Rectal Cancer: NanoEcho Imaging Study

We are exploring a new imaging method for examining rectal lymph nodes in healthy volunteers and rectal cancer patients. The goal is to assess safety and improve detection of lymph node involvement.

Rectal Cancer6-12 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Steroid Treatment for Wheezing in Children

We are studying whether a new steroid treatment can help prevent asthma in children who wheezed for the first time after a rhinovirus infection. The trial will also look at the frequency and severity of wheezing episodes over time.

Acute Wheezing/Bronchiolitis1-2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementPartially RemotePediatricsPulmonology

Pneumococcal Vaccine Response in Patients Without a Spleen

We are studying how the timing of pneumococcal vaccination affects immune response in patients who have had their spleen removed. This research may help improve vaccination strategies for asplenic individuals.

Asplenia>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementAllergologyHematologyInfectious Diseases

ADHD and Depression: Dexamfetamine Formulations Study

We are investigating the safety and effectiveness of two dexamfetamine sulfate formulations for adults with ADHD and moderate to severe depression. This study aims to see how these treatments compare to a placebo in improving symptoms and managing side effects.

Major DepressionAttention Deficit Hyperactivity Disorder (ADHD)3-6 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesPsychiatry

Mucositis in Metastatic Renal Cell Carcinoma: Folic Acid Supplement Study

We are studying whether a folic acid supplement can help reduce mucositis in patients with metastatic renal cell carcinoma receiving targeted therapy. This trial will also assess the impact on quality of life and treatment side effects.

Metastatic Renal Cell Carcinoma≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesInternal MedicineOncology

Heart Failure: Hyperpolarized MRI Study

We are investigating how the heart uses a substance called pyruvate in patients with heart failure. This study aims to see if a new imaging method can improve our understanding of heart metabolism.

Heart Failure>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal Medicine

Erectile Rehabilitation with Sildenafil After Rectal Cancer Surgery

We are studying whether Sildenafil can help men maintain erectile function after proctectomy for rectal cancer. This trial will evaluate its effects on sexual health and quality of life over the year following surgery.

Men Treated with Proctectomy for Rectal Cancer>2 yearsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementOncologyUrology

Myocarditis: Anakinra Treatment Study

We are investigating whether adding Anakinra to standard treatments helps patients with virus-negative myocarditis. This study aims to evaluate its safety and effectiveness compared to usual care.

Virus-Negative Myocarditis6-12 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCardiologyInternal Medicine

Atopic Dermatitis: RO7790121 Treatment Study

We are testing a new medication, RO7790121, for people with moderate to severe atopic dermatitis. The study aims to see if it can significantly improve skin symptoms compared to a placebo.

Atopic DermatitisEfficacy phase (II)≤5 visitsInvestigational MedicinesPartially RemoteAllergologyDermatology

Preventing Heart Issues in Cancer Patients: Empagliflozin Study

We are studying whether empagliflozin can help prevent heart problems in cancer patients undergoing chemotherapy with anthracyclines. We will compare its effects to a placebo to assess safety and effectiveness.

Cardiotoxicity1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyOncology

Emicizumab Dosing in Congenital Hemophilia A Patients

We are studying whether personalized dosing of emicizumab can effectively prevent bleeding in patients with congenital hemophilia A compared to standard dosing. This trial also examines the impact on quality of life and treatment costs.

Hemophilia A1-2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementHematology

Gout Treatment: Immediate vs. Delayed Febuxostat

We are studying whether starting febuxostat right after a gout attack helps reduce the number of gout days compared to starting it six weeks later. This trial is for individuals experiencing acute gout attacks.

Gout>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology

Ischemic Stroke: DOAC Intravenous Thrombolysis Trial

We are studying whether intravenous thrombolysis is more effective than standard care for patients with ischemic stroke who have recently taken direct oral anticoagulants. This research aims to improve recovery outcomes for these patients.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteInternal MedicineNeurology

Carotid Artery Disease: [18F]AlF-NOTA-octreotide PET/MRI Study

We are exploring a new imaging method to better understand carotid artery disease in patients who have had a recent stroke or TIA. This study aims to see if it can help identify those at risk for future strokes.

Carotid Artery Atherosclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyNeurology