Search Clinical Trials in the European Union

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2041-2060 of 3,900 trials

Colorectal Cancer: STC-1010 Immunotherapy

We are studying a new immunotherapy for patients with advanced colorectal cancer that cannot be surgically removed. The trial aims to evaluate its safety and effectiveness alongside standard treatment options.

Unresectable Locally Advanced or Metastatic Colorectal CancerSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Genetically Modified T-Cells for ROR1 Positive Tumors

We are assessing the safety and tolerability of a new treatment using genetically modified T-cells for patients with ROR1 positive tumors. This study aims to understand how these cells may help in treating this type of cancer.

Mantle Cell LymphomaOvarian CancerAdrenocortical Carcinoma>2 yearsSafety phase (I)Oncology

Heart Procedure: Protamine Use in Aortic Valve Replacement

We are studying whether protamine can help reduce major bleeding and ischemic events in patients after transcatheter aortic valve replacement. This trial also examines other safety factors and complications related to the procedure.

Transcatheter Aortic Valve Replacement (TAVR)>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Dornase Alfa for Severe Trauma Patients in ICU

We are studying whether inhaled dornase alfa can help reduce serious lung complications in ventilated patients with severe trauma. This trial aims to see if it lowers the risk of ARDS and improves recovery outcomes.

Severe TraumaConfirmation phase (III)Standard MedicinesInternal MedicinePulmonology

Gentamicin Injection for Cat Scratch Disease Lymphadenitis

We are studying whether an injection of gentamicin can improve symptoms in patients with cat scratch disease lymphadenitis compared to a placebo. This trial also looks at pain relief and lymph node changes over time.

Bartonellosis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInfectious DiseasesInternal Medicine

Inhaled Molgramostim for Pediatric Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

We are studying the effects of inhaled molgramostim in children and teens with aPAP. The goal is to see if it is safe and effective for improving their condition.

Pulmonary Alveolar Proteinosis1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPediatricsPulmonology

Progressive Vitiligo: Anifrolumab and Phototherapy Study

We are investigating whether combining anifrolumab with phototherapy helps adults with progressive vitiligo regain skin color better than phototherapy alone. The study will also assess the safety and tolerability of this new treatment approach.

Vitiligo6-12 monthsEfficacy phase (II)Standard MedicinesAllergologyDermatology

Prostate Cancer: Re-treatment with [177Lu]Lu-PSMA

We are studying the effects of re-treating men with metastatic castration-resistant prostate cancer using [177Lu]Lu-PSMA. This trial aims to see if this treatment can help improve survival and quality of life.

Metastatic Prostate Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncologyUrology

Head and Neck Cancer: Cetuximab with Chemotherapy

We are studying a combination of cetuximab and chemotherapy followed by immunotherapy for patients with recurrent or metastatic head and neck cancer. The goal is to see if this treatment improves survival and response rates for those with a specific PD-L1 score.

Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Advanced Solid Tumors: DS-2243a Treatment

We are testing a new drug called DS-2243a in people with advanced solid tumors. This study aims to see how safe it is and how well it works compared to existing treatments.

Advanced Solid Tumor>2 yearsSafety phase (I)Oncology

Cancer Imaging: [18F]AlF-FAPI-74 PET/CT

We are studying a new imaging method for patients with newly diagnosed esophagogastric and pancreatic cancers. This trial aims to see if it detects cancer better than current imaging techniques.

Pancreatic CancerEsophagogastric AdenocarcinomaGastric Cancer1-2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Apixaban in Short Bowel Syndrome Patients

We are studying how the blood levels of apixaban differ in patients with short bowel syndrome who require long-term IV nutrition. This research may help improve treatment strategies for these patients.

Short Bowel Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Haemophilia A: Efanesoctocog Alfa Treatment Study

We are investigating how efanesoctocog alfa affects joint health in patients with haemophilia A. The study aims to understand improvements in joint swelling and overall health during treatment.

Haemophilia A1-2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteHematologyOrthopedics and Traumatology

Sleeping through Menopause: Hormone Therapy and Online Sleep Support

We are studying whether hormone therapy and a guided online sleep program can help improve sleep and mood in perimenopausal women. This trial aims to enhance mental health and overall well-being during this transition.

InsomniaClimacteric Symptoms3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsPsychiatry

Neurocritical Patients: Inhalation vs. Intravenous Sedation

We are studying whether inhalation sedation with isoflurane is more effective and safer than conventional intravenous sedation for patients in critical neurological care. This trial will help us understand the best sedation methods for these patients.

Pain ReliefMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Glucothera Plus for Children on Peritoneal Dialysis

We are studying the safety of Glucothera Plus in children receiving peritoneal dialysis. We also want to see if it helps restore L-carnitine levels in these patients.

End-stage Kidney Disease6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesNephrologyPediatrics

Early Triple-Negative Breast Cancer: Durvalumab Study

We are investigating the effects of Durvalumab in patients with early-stage triple-negative breast cancer before surgery. This study aims to see if it can improve treatment outcomes.

Triple Negative Breast Cancer>2 yearsEfficacy phase (II)Oncology

B-cell Non-Hodgkin Lymphoma: Loncastuximab Tesirine Study

We are testing a new treatment combining Loncastuximab Tesirine with other anti-cancer agents for patients with relapsed or refractory B-cell Non-Hodgkin Lymphoma. The goal is to evaluate its safety and potential effectiveness.

B-cell Non-Hodgkin's Lymphoma>2 yearsSafety phase (I)Oncology

Colchicine for Peripheral Artery Disease

We are studying whether a low dose of colchicine can help reduce serious heart and limb problems in patients with peripheral artery disease. This research aims to improve safety and outcomes for those affected.

Peripheral Arterial Disease>2 yearsConfirmation phase (III)Investigational MedicinesCardiology

CNS Lymphoma: [90Y]Y-PentixaTher Therapy

We are studying the safety and effectiveness of [90Y]Y-PentixaTher in patients with recurrent or refractory central nervous system lymphoma. This trial aims to find the best dose and understand how the treatment works in the body.

CNS LymphomaSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncology