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3161-3180 of 3,900 trials

Alzheimer's Disease: Tau and Amyloid Brain Imaging Study

We are investigating how tau protein deposits in the brain can help distinguish between Alzheimer's disease and other conditions. This study may provide insights into early diagnosis and disease progression.

Alzheimer's Disease>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesPartially RemoteNeurology

Advanced Melanoma: New Treatment Combination

We are studying a new treatment approach for patients with advanced melanoma, combining immune therapies to see if it improves outcomes and reduces side effects. This trial aims to understand how well these treatments work together.

Solid Tumors3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Multiple Myeloma: Fluciclovine PET/CT Imaging Study

We are investigating a new imaging method for multiple myeloma patients to see how it compares to standard imaging. This study aims to understand its effectiveness and safety in detecting the disease.

Multiple MyelomaEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncologyOtolaryngology

Multiple Myeloma: Isatuximab Combination Therapy

We are studying a new treatment combining isatuximab with other medications for patients with newly diagnosed multiple myeloma who cannot undergo a transplant. The goal is to see how effective and safe this treatment is, and how it impacts patients' lives.

Newly Diagnosed Transplant Ineligible Multiple Myeloma>2 yearsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesHematologyOncology

ELGN-2112 for Intestinal Malabsorption in Preterm Infants

We are studying whether ELGN-2112 can help preterm infants with intestinal malabsorption achieve full feeding sooner and reduce the risk of serious complications. This trial compares the new treatment to a placebo to assess its safety and effectiveness.

Intestinal Malabsorption>2 yearsConfirmation phase (III)Standard MedicinesCost ReimbursementPartially RemoteGastroenterologyPediatrics

Alcohol Use Disorder: Sunobinop Study

We are testing whether Sunobinop can help reduce heavy drinking days for individuals with alcohol use disorder. This study aims to understand its effects on overall alcohol consumption and cravings.

Alcohol Use Disorder≤3 monthsEfficacy phase (II)Investigational MedicinesCost ReimbursementPsychiatry

Bladder Cancer: Intravesical Gemcitabine Treatment

We are studying the effectiveness and safety of a drug called gemcitabine for patients with low-grade bladder cancer. This trial aims to see how well it works in treating this specific type of cancer.

Bladder Cancer≤3 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncologyUrology

Heart Procedure: Comparing Blood Thinners

We are studying how two different blood-thinning treatments affect blood clotting in patients undergoing closure of heart defects. This may help us understand which treatment is safer and more effective after the procedure.

Patent Foramen Ovale (PFO) / Atrial Septum Defect (ASD)>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCardiologyInternal Medicine

Rectal Cancer: Atezolizumab and Bevacizumab After Radiotherapy

We are studying a new treatment for low- to intermediate-risk rectal cancer to see if it helps prevent disease relapse and preserves organ function. The trial also evaluates the safety of this approach.

Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Menstrual Migraine: Rimegepant Study

We are investigating whether Rimegepant can help prevent menstrual migraines in women aged 18 to 45. This study compares its effects to a placebo to see if it reduces migraine frequency and improves quality of life.

Menstrual Migraine6-12 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesGynecology and ObstetricsNeurology

Ulcerative Colitis: Encapsulated Stool Microbiome Study

We are investigating whether long-term treatment with encapsulated stool microbiome can improve symptoms in people with active ulcerative colitis. This study compares the treatment to a placebo to assess its effectiveness.

Active Ulcerative Colitis≤3 monthsConfirmation phase (III)Investigational MedicinesGastroenterologyInfectious Diseases

Multiple Myeloma: ABBV-453 Treatment Study

We are studying the safety and effects of ABBV-453, alone or with other treatments, for adults with multiple myeloma. This research aims to understand how well it works and how it is tolerated by patients.

Multiple MyelomaSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Advanced Solid Tumors: GSK5733584 with Anti-Cancer Therapies

We are studying a new drug, GSK5733584, combined with other cancer treatments for patients with advanced solid tumors. The trial aims to evaluate its safety and how well it may work in this setting.

Gynecological TumorsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Cervical Dysplasia: Improving Diagnosis with Estrogen

We are studying whether vaginal estrogen can improve the detection of precancerous cervical lesions in women aged 50 and older. This may help reduce the risk of cervical cancer and improve follow-up care.

HPV Positive with Cervical DysplasiaMonitoring phase (IV)Standard MedicinesGynecology and ObstetricsInternal Medicine

Antibiotics in Bile Fluid: A Study for Patients with Biliary Drainage

We are investigating how antibiotics are processed in the bile of patients with external biliary drainage. This research may help improve treatment strategies for these patients.

Cholangitis1-2 yearsSafety phase (I)GastroenterologyHepatology

Chronic Hepatitis Delta: BJT-778 vs Bulevirtide

We are studying a new treatment called brelovitug for chronic hepatitis delta infection to see if it works better and is safer than the current treatment, bulevirtide. We also want to understand how it affects patients' quality of life.

Chronic Hepatitis D Infection1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHepatologyInfectious Diseases

Multiple System Atrophy: Lu AF82422 Study

We are testing the medication Lu AF82422 to see if it can slow disease progression in people with Multiple System Atrophy. The study will also look at its effects on overall health and quality of life.

Multiple System Atrophy1-2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Bipolar Depression: Lithium vs. Cariprazine

We are comparing the effectiveness of lithium and cariprazine for treating acute depressive episodes in people with bipolar disorder. The goal is to find out which medication may lead to better improvements in mood.

Depressive Episode in Bipolar Disorder≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Sarcopenia Treatment: Nandrolone and Therapy

We are studying whether nandrolone, along with physiotherapy and diet, can improve muscle strength in people with sarcopenia. This research aims to find effective treatments for muscle loss.

Sarcopenia≤3 monthsEfficacy phase (II)Standard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Ovarian Cancer: Mirvetuximab Soravtansine Study

We are evaluating different dosing schedules of mirvetuximab soravtansine for patients with advanced ovarian, peritoneal, or fallopian tube cancers. This study aims to find the safest and most effective way to administer the treatment.

Advanced Ovarian and Fallopian Tube Cancer6-12 monthsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsOncology