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3241-3260 of 3,900 trials

Nasopharyngeal Cancer: Nivolumab Treatment Study

We are studying the effectiveness of Nivolumab for patients with nasopharyngeal cancer who have progressed after chemotherapy. We also want to understand how safe this treatment is for these patients.

Nasopharyngeal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncology

Throat and Larynx Cancer: Low-Dose Radiation Therapy

We are studying a new treatment combining low doses of radiation and chemotherapy for patients with advanced throat and larynx cancer. The goal is to see if this approach improves treatment outcomes and is well-tolerated.

Throat and Larynx Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

Opioid Use Disorder: Daridorexant Treatment

We are studying whether daridorexant can help reduce illicit substance use in people with opioid use disorder already on buprenorphine. The trial also looks at improvements in cravings, withdrawal symptoms, and overall treatment retention.

Opioid Use Disorder≤3 monthsEfficacy phase (II)11-15 visitsStandard MedicinesPsychiatry

Type 1 Diabetes: Fenofibrate Study for Children

We are testing whether fenofibrate can help maintain beta cell function in children newly diagnosed with type 1 diabetes. The study also looks at the safety of this medication for young patients.

Type 1 Diabetes1-2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesEndocrinologyPediatrics

Heart Inflammation: Immunosuppressive Treatment Study

We are studying whether a combination of prednisone and azathioprine can improve heart function in patients with inflammatory heart disease. This trial compares the treatment to a placebo to see if it offers any benefits.

Myocarditis>2 yearsMonitoring phase (IV)11-15 visitsStandard MedicinesCardiologyInternal Medicine

Breast Cancer Diagnosis: Contrast-Enhanced Spectral Mammography

We are evaluating a new imaging method to see if it improves the accuracy of breast cancer diagnosis. This may help reduce the number of unnecessary biopsies for suspicious lesions.

Breast Lesions6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

Infantile Spasms: Vigabatrin for High-Risk Children

We are studying whether vigabatrin can prevent infantile spasms in children under 1 year old who are at high risk due to conditions like tuberous sclerosis. This research aims to improve outcomes for these vulnerable infants.

High-Risk Infantile Spasm Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurology

Alcohol Use Disorder: Psilocybin Treatment

We are studying if a single dose of psilocybin can help reduce heavy drinking in people with alcohol use disorder. This trial compares the effects of psilocybin to a placebo over 12 weeks.

Alcohol Use Disorder>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementPsychiatry

Duchenne Muscular Dystrophy: ENTR-601-45 Treatment Study

We are evaluating a new treatment for Duchenne muscular dystrophy to see if it is safe and well-tolerated. This study will help us understand how the treatment works in the body.

Duchenne Muscular Dystrophy6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Preventing Infections After Hysterectomy: Azithromycin vs. Cefuroxime

We are studying whether a combination of azithromycin and cefuroxime can better prevent infections after hysterectomy compared to cefuroxime alone. This research aims to improve antibiotic use in surgical settings.

Undergoing Hysterectomy>2 yearsMonitoring phase (IV)Investigational MedicinesGynecology and ObstetricsInfectious Diseases

Post-Surgery Pain Management: Comparing Two Techniques

We are studying the effectiveness of two different nerve block methods for pain relief after laparoscopic colon surgery. Our goal is to see if these methods work better than traditional oral pain medications.

Colon Surgery for Cancer or Diverticulosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngology

Efgartigimod and Emasiprubart: Healthy Adult Study

We are examining how the drug efgartigimod affects emasiprubart in healthy adults. This research aims to gather information on their interaction for future treatments.

Healthy Participants1-2 yearsSafety phase (I)

Grass Pollen Allergy: CLU-RX-PHL Treatment

We are testing a new subcutaneous treatment for people with grass pollen allergy. The study aims to find the most effective and safest dose to help manage allergy symptoms.

Allergic Rhinitis Due to Pollen6-12 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesAllergologyInternal Medicine

Grass Pollen Allergy: Sublingual Immunotherapy Study

We are evaluating a new sublingual treatment for people with grass pollen allergies to see if it effectively reduces allergy symptoms. The study will also assess the safety of different doses.

Allergic Rhinitis due to PollenEfficacy phase (II)Confirmation phase (III)Investigational MedicinesAllergology

Chronic Inflammatory Demyelinating Polyneuropathy: DNTH103 Treatment Study

We are studying a new treatment called DNTH103 for adults with Chronic Inflammatory Demyelinating Polyneuropathy. The trial aims to see if it can help reduce relapses and improve overall health compared to a placebo.

Chronic Inflammatory Demyelinating Polyneuropathy>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementNeurology

Severe Asthma: Tezepelumab Treatment

We are exploring how Tezepelumab may improve airway barrier function in patients with severe asthma, including those with chronic rhinosinusitis. This study looks at the effects of the treatment on the airways' response to harmful substances.

Severe Asthma with Chronic Rhinosinusitis and Nasal PolypsSevere Asthma without Chronic Rhinosinusitis>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesAllergologyOtolaryngologyPulmonology

FB301: First-in-Human Study

We are testing a new medication called FB301 in healthy women to evaluate its safety and how it is processed in the body. This study aims to gather important information for future research.

InfertilitySafety phase (I)Gynecology and Obstetrics

Neovascular Age-Related Macular Degeneration: Faricimab Injections

We are studying the safety and long-term effectiveness of faricimab injections for people with neovascular age-related macular degeneration. The goal is to see if it improves vision and how well it works over time.

Neovascular Age-Related Macular Degeneration>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOphthalmology

Rheumatoid Arthritis: ABO21009 Treatment Study

We are testing a new treatment called ABO21009 in healthy volunteers and patients with rheumatoid arthritis. The goal is to see how it compares to a placebo in terms of safety and effects.

Rheumatoid Arthritis>2 yearsSafety phase (I)Rheumatology

ALK-Positive Advanced Lung Cancer: NVL-655 vs. Alectinib

We are studying a new medication, NVL-655, for patients with advanced ALK-positive lung cancer who haven't been treated before. The goal is to see if it works better and is safer than the current standard treatment, alectinib.

Advanced ALK-positive Non-Small Cell Lung CancerConfirmation phase (III)16-20 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology