Search Clinical Trials in the European Union

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3361-3380 of 3,900 trials

Prostate Cancer: Ebastine with Docetaxel or Cabazitaxel

We are studying a new treatment combining ebastine with either docetaxel or cabazitaxel for men with metastatic castration-resistant prostate cancer. The goal is to evaluate how this combination affects cancer markers and PSA levels.

Hormone-Refractory Prostate Cancer3-6 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncologyUrology

Skin Irritation Study: New 5% Lidocaine Plaster

We are testing a new medicated plaster to see if it causes skin irritation or sensitization in healthy volunteers. This research aims to ensure the safety of the product for future use.

Post Herpetic Neuralgia6-12 monthsSafety phase (I)DermatologyNeurology

Small Cell Lung Cancer: 177Lu-EVG321 Treatment

We are testing a new drug to see if it is safe and how well the body tolerates it in patients with small cell lung cancer. This study aims to gather important information for future treatments.

Small Cell Lung Cancer>2 yearsSafety phase (I)OncologyPulmonology

Opioid-Induced Respiratory Depression: Naloxone and Nalmefene Study

We are studying how well naloxone and nalmefene can reverse breathing problems caused by opioids in both new and long-term users. This research aims to improve treatment options for respiratory depression in real-life settings.

Healthy VolunteersOpioid Use Disorder>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal MedicineOtolaryngologyPulmonology

Schizophrenia: Cariprazine for Cognitive Function

We are studying how cariprazine affects cognitive functioning in patients with schizophrenia who need changes to their current treatment. The trial will also look at overall quality of life and any side effects.

Acute Schizophrenia6-12 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPsychiatry

Penile and Tongue Cancer: New Imaging Technique

We are evaluating a new fluorescent imaging method to help surgeons visualize tumors and lymph node spread during surgery for penile and tongue cancer. This study aims to improve detection and assess any side effects.

Penile CancerTongue Cancer1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncologyUrology

Cardiac Arrest and Ventricular Fibrillation: RIME-IVF Study

We are investigating how beta-blocker treatment affects patients with idiopathic ventricular fibrillation and those who have had out-of-hospital cardiac arrests. We also aim to understand the quality of life for survivors of cardiac arrest.

Idiopathic Ventricular FibrillationMonitoring phase (IV)No PlaceboStandard MedicinesCardiology

Orthopedic Surgery: Intraoperative Methadone Study

We are investigating whether methadone can reduce pain and improve satisfaction after orthopedic surgery compared to standard pain relief methods. This study aims to ensure safety while managing postoperative pain effectively.

Orthopedic Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder

We are studying whether a high dose of psilocybin can help reduce heavy drinking in people with severe alcohol use disorder during inpatient rehabilitation. This trial also examines the safety and effects on mental health and cognitive function.

Severe Alcohol Use Disorder6-12 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPsychiatry

Acute Myeloid Leukemia: Eganelisib Treatment Study

We are studying the safety and tolerability of eganelisib alone and with cytarabine in patients with relapsed or refractory acute myeloid leukemia. This trial aims to find the best dose and evaluate how well the treatment works.

Relapsed/Refractory Acute Myeloid LeukemiaHigher-Risk Myelodysplastic SyndromesSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesHematologyOncology

Locally Advanced Rectal Cancer: FOLFOX Before Surgery

We are comparing the effects of chemotherapy before surgery to risk-adapted chemotherapy after surgery for patients with locally advanced rectal cancer. Our goal is to see which approach may lead to better disease-free survival and fewer complications.

Locally Advanced Rectal Cancer≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Advanced Solid Tumors: INP12 Treatment

We are evaluating the safety and how the body handles a new treatment called INP12 in patients with advanced solid tumors. This study aims to understand if INP12 is safe for further testing.

Solid Tumor>2 yearsSafety phase (I)Oncology

Immunotherapy for MSI/dMMR Tumors: Pembrolizumab Study

We are studying the effects of pembrolizumab in patients with untreated localized MSI/dMMR tumors or EBV+ gastric cancer. The goal is to see if this treatment improves outcomes before and after surgery.

MSI/dMMR Tumors and EBV+ Gastric Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

ABO-101 for Primary Hyperoxaluria Type 1

We are testing a new treatment, ABO-101, to see if it is safe and well-tolerated in people with Primary Hyperoxaluria Type 1. The study will also explore how the body reacts to the treatment.

Primary Hyperoxaluria>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteEndocrinologyNephrology

Lung Cancer: RMC-6236 vs. Docetaxel

We are studying a new treatment for patients with advanced lung cancer who have RAS mutations. The goal is to see if RMC-6236 works better than the standard treatment, docetaxel.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Moderate Atopic Dermatitis: Ruxolitinib Cream for Kids

We are studying a new cream for children and adolescents aged 6 to under 18 with moderate atopic dermatitis who haven't had success with other treatments. The trial will assess how well it works and its safety.

Atopic Dermatitis1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Alcohol Dependence: CBD and Naltrexone Study

We are investigating whether adding Cannabidiol to Naltrexone helps reduce alcohol cravings in people with alcohol dependence. The study also looks at its effects on mood, anxiety, and overall quality of life.

Alcohol Dependence>2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemotePsychiatry

EGFR-Mutated Lung Cancer: ERIS Study

We are exploring the best sequence of EGFR-inhibitors for patients with EGFR-mutated lung cancer. The study also examines treatment effects, side effects, and quality of life.

EGFR-Mutated Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncology

Cancer Anorexia: ART27.13 Cannabinoid Study

We are testing a new synthetic cannabinoid to see if it helps patients with cancer gain weight and improve appetite. The study also looks at the safety and quality of life for participants.

Cancer Anorexia3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementInternal MedicineOncology

Hidradenitis Suppurativa: IC0624 Treatment Study

We are testing a new medication, IC0624, for people with mild to moderate Hidradenitis Suppurativa. The study will help us understand its effects on symptoms, pain, and overall quality of life.

Hidradenitis Suppurativa≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesDermatology