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3321-3340 of 3,900 trials

Prostate Cancer: Atorvastatin Study

We are investigating whether atorvastatin can help delay prostate cancer progression in men receiving androgen deprivation therapy. This study aims to see if it can prevent the cancer from becoming resistant to treatment.

Metastatic Prostate Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesOncologyUrology

Soft Tissue Sarcoma: Pembrolizumab with Radiotherapy

We are studying whether adding pembrolizumab to radiotherapy before and after surgery helps patients with high-risk localized soft tissue sarcoma live longer without disease recurrence. This trial compares this approach to standard treatment with radiotherapy and surgery alone.

High-Risk Soft Tissue Sarcoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOrthopedics and Traumatology

ADPKD Treatment: Metformin vs. Tolvaptan

We are studying whether Metformin can effectively slow kidney function decline in adults with Autosomal Dominant Polycystic Kidney Disease compared to Tolvaptan. The trial also examines the safety and impact on kidney size and symptoms.

Autosomal Dominant Polycystic Kidney Disease>2 yearsConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Moderate-to-Severe Asthma: PF-07275315 Study

We are investigating a new medication called PF-07275315 for adults with moderate-to-severe asthma. The study aims to see if it is more effective than a placebo in improving asthma control and quality of life.

Moderate-to-Severe Asthma6-12 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementAllergologyPulmonology

Bone Infections: Clindamycin and Cefalexin Study

We are investigating how well clindamycin and cefalexin penetrate bone tissue in patients. This study aims to improve treatment options for bone infections.

Patients Undergoing Amputation SurgerySafety phase (I)Infectious DiseasesOrthopedics and Traumatology

Understanding ABCB1's Role in Metoclopramide Effects

We are studying how a gene may influence the way metoclopramide works in the brain for individuals taking this medication. This research aims to improve treatment outcomes for patients using metoclopramide.

Healthy ParticipantsSafety phase (I)Internal MedicineNeurology

Hydrocortisone Treatment in Pancreatoduodenectomy Surgery

We are studying whether hydrocortisone infusions can help reduce complications after pancreatoduodenectomy surgery. This trial compares the effects of hydrocortisone to a placebo in patients undergoing this procedure.

Pancreatic Resection>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Nephrotic Syndrome: Ketoanalogues for Muscle Preservation

We are studying a new treatment to help prevent muscle loss in patients with nephrotic syndrome. This trial will assess its safety and how it may improve overall health and quality of life.

Protein-Energy Wasting in Nephrotic Syndrome>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

ANCA-Associated Vasculitis: Rituximab Treatment Study

We are comparing a combination of rituximab and cyclophosphamide to standard treatment for achieving remission in severe ANCA-associated vasculitis. The trial also looks at how different ways of giving rituximab can help maintain remission.

ANCA-Associated Vasculitis6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineRheumatology

Bone Health: Cagrilintide Study

We are investigating how the amylin analogue Cagrilintide affects bone metabolism in participants. This study aims to learn more about its potential role in improving bone health.

Obesity in Post-Menopausal WomenSafety phase (I)EndocrinologyInternal Medicine

Kidney Health After Transplant: Dapagliflozin Study

We are studying how dapagliflozin affects kidney structure and inflammation in patients with impaired kidney function one year after transplantation. This research may help us understand better treatments for kidney transplant recipients.

Chronic Kidney Disease (CKD)3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyNephrology

Infant Immunity to Whooping Cough: Maternal Vaccination Study

We are studying how vaccines given to pregnant women affect their infants' immunity to whooping cough. Our goal is to find out what factors influence the transfer of protective antibodies from mothers to their babies.

Whooping Cough>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsInfectious DiseasesInternal Medicine

Rheumatoid Arthritis: F8IL10 Injection Study

We are exploring different doses of an injection for people with rheumatoid arthritis. The goal is to find out how well it works and its safety profile.

Rheumatoid Arthritis>2 yearsSafety phase (I)Rheumatology

Atherosclerosis: Psilocybin Therapy Study

We are exploring if psilocybin-assisted therapy can help reduce plaque buildup in patients with ischemic heart disease. This study will also look at safety and changes in plaque characteristics over time.

Stable Ischemic Heart DiseaseEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCardiologyInternal Medicine

Knee Osteoarthritis: SYN321 Injection Study

We are testing a new injection for people with knee osteoarthritis to see if it is safe and effective. The study compares different doses of SYN321 to a placebo to assess its impact on symptoms.

Knee Osteoarthritis≤3 monthsSafety phase (I)Efficacy phase (II)Investigational MedicinesInternal MedicineOrthopedics and Traumatology

Midgut Neuroendocrine Tumors: Lu177-Dotatate Treatment Schedule

We are studying whether giving Lu177-Dotatate every 16 weeks can lower serious side effects for patients with advanced midgut neuroendocrine tumors. This trial compares the new schedule to the standard treatment given every 8 weeks.

Small Intestine Neuroendocrine Tumor>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyOncology

Small Cell Lung Cancer: MK-6070 and Ifinatamab Deruxtecan Study

We are studying the safety and effectiveness of MK-6070 combined with ifinatamab deruxtecan in people with advanced small cell lung cancer. This trial aims to find better treatment options for those whose cancer has returned or is hard to treat.

Small Cell Lung Cancer>2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesOncology

Septic Shock: Comparing Sodium Lactate and Saline Solutions

We are studying how two different intravenous fluids affect blood flow and acid-base balance in patients with septic shock. This research may help improve treatment options for this serious condition.

Septic Shock>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicinePulmonology

Long COVID: Fibroblast Activity Study with [68Ga]FAPI PET/CT

We are investigating if patients with ongoing long COVID symptoms have higher fibroblast activity than those who have recovered. This may help us understand the underlying causes of long-term health issues after COVID-19.

Long COVIDConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesCost ReimbursementInternal MedicinePulmonology

Cardiac AL Amyloidosis: PET/CT Imaging Study

We are studying a new non-invasive imaging method to diagnose cardiac AL amyloidosis in patients with a specific type of protein in their blood. This research aims to see if this method is as effective as traditional invasive tests.

Cardiac Amyloidosis1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine