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3301-3320 of 3,900 trials

Lower Limb Nonunion: NVD-003 Implant Study

We are testing a new 3D bone implant for adults with nonunion fractures in the lower limb. The study aims to evaluate its safety and effectiveness in promoting healing and improving quality of life.

Recalcitrant Lower Limb Nonunion1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and Traumatology

End-of-Life Care: Midazolam and Morphine Study

We are investigating how midazolam and morphine can help relieve pain and discomfort in elderly patients during their final days. This study aims to understand the best dosing strategies and any potential side effects.

Symptom Treatment in End-of-Life Care for Geriatric Patients1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Cardiac Surgery: Angiotensin II vs. Noradrenaline

We are studying whether angiotensin II can better prevent kidney injury compared to noradrenaline in patients undergoing cardiac surgery. This research may help improve kidney health outcomes after surgery.

Acute Kidney Injury>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicineNephrology

Head and Neck Cancer: TB0010 Treatment Study

We are evaluating the safety and tolerability of TB0010 in patients with head and neck squamous cell carcinoma. This study aims to understand how the drug is distributed in the body.

EGFR-Positive Head and Neck Squamous Cell Carcinoma1-2 yearsSafety phase (I)Oncology

Lung Cancer Treatment: Rilvegostomig vs. Pembrolizumab

We are studying a new drug, rilvegostomig, to see if it works better than pembrolizumab for patients with PD-L1-high metastatic non-small cell lung cancer. This trial aims to understand which treatment may improve survival and quality of life.

Lung CancerConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology

Metastatic Renal Cell Carcinoma: Immunotherapy and Tumor Treatment Study

We are studying how surgery and radiation affect survival and tumor growth in patients with metastatic renal cell carcinoma receiving immunotherapy. This trial aims to improve treatment strategies and quality of life for these patients.

Advanced Kidney Cancer1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Crohn's Disease: New Cellular Treatment for Fistulas

We are studying a new injection of fat-derived cells for people with complex perianal Crohn's fistulas. The goal is to see if this treatment helps heal fistulas better than a placebo.

Crohn's Disease>2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Cisternal Lavage Therapy for Aneurysmal Subarachnoid Hemorrhage

We are studying a new treatment using Urokinase and Nimodipine for patients with aneurysmal subarachnoid hemorrhage. The aim is to see if this therapy improves brain function and is safe.

Aneurysmal Subarachnoid Hemorrhage≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesNeurology

Sacubitril/Valsartan for Heart Protection in Breast Cancer Treatment

We are studying whether sacubitril/valsartan can help prevent heart damage in women receiving systemic treatment for breast cancer. This trial aims to understand its potential benefits in protecting heart function during therapy.

Heart Failure>2 yearsConfirmation phase (III)Investigational MedicinesCardiologyOncology

Hemophilia A: Efanesoctocog Alfa Treatment Study

We are studying the long-term effects of efanesoctocog alfa on joint health in people with hemophilia A. The trial aims to see how well it prevents joint bleeds and improves quality of life.

Haemophilia A1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOrthopedics and Traumatology

Gastric Cancer: Personalized Immunotherapy Study

We are exploring new personalized immunotherapy treatments for patients with advanced gastric cancer. The goal is to see if these targeted therapies can improve outcomes for those with recurrent or metastatic disease.

Metastatic Gastric Adenocarcinoma>2 yearsEfficacy phase (II)Oncology

Advanced Non-Small Cell Lung Cancer: M9140 Treatment Study

We are studying a new drug called M9140 for people with advanced non-small cell lung cancer. The goal is to see how well it works and how safe it is compared to existing treatments.

Non-Small Cell Lung Cancer6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Advanced Pancreatic Cancer: M9140 Treatment Study

We are studying a new drug called M9140 for people with advanced pancreatic cancer to see how well it works and how safe it is. This trial aims to evaluate its effectiveness and side effects compared to standard treatments.

Metastatic Pancreatic Cancer6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Cystic Fibrosis: Inhaled Teicoplanin Study

We are evaluating the safety and tolerability of inhaled Teicoplanin for cystic fibrosis patients with persistent Staphylococcus aureus infections. The study aims to see if it can improve lung function and reduce infection levels.

Cystic Fibrosis with Staphylococcus Aureus Infection1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Chronic Urticaria: Briquilimab Study

We are studying the long-term safety and effectiveness of briquilimab in people with chronic urticaria. This trial includes participants from earlier studies to see how well the treatment works over time.

Chronic UrticariaEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesAllergologyDermatology

Graves' Ophthalmopathy: Diclofenac vs. Simvastatin

We are studying whether diclofenac or simvastatin can help patients with mild to moderate Graves' ophthalmopathy. The trial aims to assess the activity of the disease and its progression to more severe forms.

Graves' Ophthalmopathy6-12 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesEndocrinologyOphthalmology

High-Risk Melanoma: Neoadjuvant Pembrolizumab Study

We are studying the effects of pembrolizumab in patients with high-risk melanoma who have no signs of spread. The goal is to see if this treatment can improve outcomes before surgery.

Melanoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Neurogenic Orthostatic Hypotension: Fludrocortisone Treatment

We are studying whether fludrocortisone can improve blood pressure and reduce symptoms in patients with neurogenic orthostatic hypotension. The trial will also assess the safety and quality of life for participants.

Neurogenic Orthostatic Hypotension≤3 monthsMonitoring phase (IV)Investigational MedicinesInternal MedicineNeurology

DAVINCY Trial: (fos)Aprepitant for Nausea in Children

We are studying whether a longer duration of (fos)aprepitant can better prevent nausea and vomiting in children receiving chemotherapy. This trial compares the standard treatment with an extended regimen to find the most effective approach.

Delayed Chemotherapy Induced Nausea and VomitingConfirmation phase (III)Investigational MedicinesPartially RemoteInternal MedicineOncologyPediatrics

Drug Resistance in Cancer: PET Imaging Study

We are exploring how a protein linked to drug resistance behaves in cancer patients using advanced imaging. This study aims to improve our understanding of treatment challenges in cancer care.

Healthy ParticipantsSafety phase (I)Neurology