Search Clinical Trials in the European Union

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21-40 of 552 trials

Graft-Versus-Host Disease: Anti-Lymphocyte Serum Study

We are studying how the anti-lymphocyte serum works in children and adults receiving stem cell transplants. This research aims to improve prevention strategies for graft-versus-host disease.

Stem Cell Transplant1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyPediatrics

Ovarian Cancer: Mirvetuximab Soravtansine with Bevacizumab

We are studying a new treatment combining mirvetuximab soravtansine and bevacizumab for adults with recurrent ovarian cancer who have not progressed after chemotherapy. The goal is to see if this combination helps patients live longer without their cancer worsening.

Ovarian and Fallopian Tube Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGynecology and ObstetricsOncology

Staphylococcal Joint Infection: Rifampicin vs. Clindamycin

We are studying whether a targeted antibiotic can effectively treat staphylococcal infections in joint prostheses compared to a traditional combination therapy. This trial also examines quality of life and any side effects experienced by participants.

Prosthetic Joint Infection1-2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInfectious DiseasesOrthopedics and Traumatology

Metformin Transfer in Breast Milk: A Study for Lactating Women

We are investigating how metformin, used for Type 2 Diabetes, transfers into breast milk and affects breastfeeding infants. This research aims to ensure the safety of breastfeeding while on this medication.

Type 2 Diabetes and Gestational Diabetes≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyPediatrics

T-Cell Lymphoma: Autologous Stem Cell Transplantation Study

We are investigating whether autologous stem cell transplantation helps patients with T-cell lymphoma who have responded well to initial chemotherapy. This study aims to see if it improves their chances of staying cancer-free longer.

Peripheral T-cell Lymphoma>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyOncology

Takotsubo Syndrome: New Treatment Approaches

We are studying whether a combination of adenosine and dipyridamole improves outcomes for patients with Takotsubo Syndrome. Additionally, we’re testing if apixaban can lower the risk of blood clots in these patients.

Takotsubo Syndrome>2 yearsMonitoring phase (IV)Standard MedicinesPartially RemoteCardiologyInternal Medicine

Oxygen Therapy for AECOPD: Standard vs Targeted Approach

We are investigating whether a targeted oxygen therapy can reduce mortality and improve breathing in patients with acute exacerbations of chronic obstructive pulmonary disease. This study compares it to standard oxygen treatment to see which is more effective.

COPD Exacerbation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Osteoarthritis: Walking Rehabilitation with Anti-Inflammatory Treatment

We are exploring how a specific anti-inflammatory medication can support a walking rehabilitation program for people with hip or knee osteoarthritis. The goal is to see if this combination improves walking ability and overall comfort.

Osteoarthritis of the Hip or Knee≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Rheumatoid Arthritis: Precision Therapy Using Biomarkers

We are studying if tissue samples can help identify which RA patients will respond best to new biologic treatments. This may improve treatment outcomes for those who haven't benefited from standard therapies.

Rheumatoid ArthritisMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesRheumatology

Nuwiq for Managing Bleeding in Hemophilia A Patients During Surgery

We are studying how well Nuwiq works alongside emicizumab for patients with severe hemophilia A undergoing major surgery. The goal is to see if it helps control bleeding effectively and safely.

Haemophilia AMonitoring phase (IV)No PlaceboStandard MedicinesHematology

Nuwiq for Women and Girls with Hemophilia A Needing Surgery

We are studying how well Nuwiq works to control bleeding during major surgery for women and girls with hemophilia A. The trial will also look at its safety and effects on blood product use.

Haemophilia A≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyInternal Medicine

Semaglutide for Glucose Intolerance in Women with Prior Gestational Diabetes

We are studying whether semaglutide can help women with a history of gestational diabetes manage glucose intolerance and reduce the risk of developing type 2 diabetes.

Prediabetes>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyGynecology and Obstetrics

Atrial Fibrillation: WOEST-3 Study

We are exploring a new antithrombotic strategy for patients with atrial fibrillation undergoing heart procedures. The goal is to see if this approach reduces bleeding and heart-related risks compared to standard treatment.

Atrial FibrillationAcute Coronary SyndromeChronic Coronary Syndrome1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine

Semaglutide for Weight Loss in Low Responders After Bariatric Surgery

We are studying whether Semaglutide 2.4 mg can help individuals who haven't lost enough weight after bariatric surgery. This trial compares its effects with a placebo to see how it impacts weight loss and overall health.

Obesity1-2 yearsMonitoring phase (IV)>20 visitsStandard MedicinesDiabetologyEndocrinologyInternal Medicine

Bladder Cancer Treatment: Chemoablation vs. Standard Care

We are studying whether a new chemoablation method is more effective than standard bladder surgery and chemotherapy for patients with recurrent non-muscle invasive bladder cancer. This may help reduce recurrence rates and improve long-term outcomes.

Recurrent Non-Muscle Invasive Bladder Cancer>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementOncologyUrology

HPV Vaccine Effectiveness Study for Young Men

We are studying how well the bivalent HPV vaccine protects men aged 19-26 who have sex with men from anal HPV-16/18 infections. This research aims to understand vaccination impact and related factors.

HPV InfectionHealthy Participants6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious Diseases

Heart Failure: Comparing Spironolactone and Eplerenone

We are studying whether spironolactone or eplerenone is more effective in reducing the risk of death for patients with heart failure. This trial is for those receiving treatment in a heart failure clinic.

Heart Failure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Atrial Fibrillation: Warfarin Study for Dialysis Patients

We are investigating the safety and effectiveness of warfarin in patients with atrial fibrillation who are on dialysis. This study aims to understand how this medication impacts their health.

Atrial FibrillationEnd-Stage Renal Disease>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyNephrology

Osteoporosis: Zoledronate After Denosumab

We are studying if zoledronate can prevent bone loss in patients with osteoporosis who have stopped denosumab treatment. This trial also looks at how this treatment affects muscle strength and insulin sensitivity.

Osteoporosis>2 yearsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngology

Relapsing Multiple Sclerosis: Rituximab vs. Ocrelizumab

We are studying whether rituximab is as effective as ocrelizumab for treating relapsing MS. This trial is for patients who are starting anti-CD20 therapy.

Multiple Sclerosis>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineNeurology