Search Clinical Trials in the European Union

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501-520 of 552 trials

SGLT-2 Inhibitors for Elderly Patients with Type 2 Diabetes

We are comparing different SGLT-2 inhibitors to see which helps elderly patients manage their blood sugar levels safely. The study looks at effectiveness and potential side effects over time.

Type 2 DiabetesMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesDiabetologyEndocrinology

High Blood Pressure: Metyrapone for Adrenal Tumors

We are studying if adding Metyrapone helps patients with high blood pressure and adrenal tumors manage their condition better. This trial aims to improve blood pressure control in those with subclinical Cushing's syndrome.

Adrenal Incidentalomas and Mild Cushing’s Syndrome>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCardiologyEndocrinology

X-ALD: Pramipexole for Leg Symptoms

We are investigating whether pramipexole can help reduce restless leg symptoms in women with X-linked Adrenoleukodystrophy. This study aims to improve their sleep and walking performance.

X-linked AdrenoleukodystrophyRestless Legs Syndrome3-6 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurology

Advanced Clear-Cell Renal Carcinoma: Digital Monitoring with Cabozantinib and Nivolumab

We are studying how digital tracking of symptoms can help adjust treatments for patients with advanced clear-cell renal carcinoma receiving Cabozantinib and Nivolumab. This may improve their overall health and quality of life during treatment.

Kidney Cancer>2 yearsMonitoring phase (IV)16-20 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncologyUrology

Basal Cell Carcinoma: Electrochemotherapy vs. Radiotherapy

We are comparing a new treatment called electrochemotherapy with standard radiotherapy for small basal cell carcinomas. The study will also assess side effects, appearance after treatment, and patient satisfaction.

Basal Cell Carcinoma>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesDermatologyOncology

Staphylococcus Aureus Bacteremia: Comparing Antibiotic Durations

We are studying whether 7 days of antibiotic treatment is as effective as 14 days for patients with uncomplicated Staphylococcus aureus bacteremia. This may help reduce antibiotic use and hospital stays.

Staphylococcus aureus Bacteremia≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Ravulizumab Dosing for PNH Patients

We are studying whether personalized dosing of ravulizumab is more effective than standard dosing for adults with PNH. This trial also looks at patient preferences and treatment costs.

Paroxysmal Nocturnal Hemoglobinuria1-2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyInternal Medicine

Emergency Pain Relief: Sublingual Sufentanil Study

We are investigating whether sublingual sufentanil can effectively manage moderate to severe pain in emergency patients after a single trauma. The study will also assess safety and compare it to standard pain management methods.

Pain in Limb6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPsychiatry

PCOS Fertility: Letrozole vs. Gonadotropins

We are studying whether continuing ovulation induction with letrozole is more effective than switching to gonadotropins for women with polycystic ovary syndrome. The trial also looks at safety, quality of life, and costs related to fertility treatment.

Polycystic Ovary Syndrome (PCOS)1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and ObstetricsInternal Medicine

Dry Eye Disease: PRGF Eye Drops for Glaucoma Patients

We are studying whether PRGF eye drops can help relieve dry eye symptoms in patients with glaucoma. The trial also looks at the safety of these eye drops for this condition.

GlaucomaDry Eye Disease≤3 monthsConfirmation phase (III)Monitoring phase (IV)Investigational MedicinesOphthalmology

Bowel Dysfunction After Rectal Cancer Surgery: Irrigation vs. Suppositories

We are comparing transanal irrigation and glycerol suppositories to see which treatment better improves bowel function and quality of life for patients after rectal cancer surgery.

Low Anterior Resection Syndrome≤3 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Lung Transplantation: Heparin-Free Heart-Lung Support

We are studying a new method of heart-lung support without blood thinners during lung transplantation. This trial aims to see if it is safe and effective for improving patient outcomes.

Lung Transplantation1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Vaginal Estrogen Treatment: Effects on Blood Clotting

We are studying how local vaginal estrogen affects blood clotting in postmenopausal women. This includes examining its impact on women with a history of blood clots.

Vulvovaginal Atrophy>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Chronic Rhinosinusitis: Stopping Treatment Study

We are investigating if patients with severe nasal polyps can safely stop treatment after a year without symptoms. We also want to see if one medication works better than the other for achieving this.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Reducing Complications After Pancreatoduodenectomy: HOP Bundle Study

We are investigating whether a combination of hydrocortisone, octreotide, and a teres ligament patch can help prevent major complications in patients undergoing high-risk pancreatoduodenectomy. This study also looks at its effect on specific complications like pancreatic fistulas.

Resectable Pancreatic Cancer3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOncologyOrthopedics and Traumatology

Liver Surgery: Blood Clot Prevention Study

We are comparing two methods of preventing blood clots in patients undergoing liver resection. The goal is to find out which method is safer and more effective in reducing clot risks.

Liver SurgeryMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyHematologyOrthopedics and Traumatology

Chronic Rhinosinusitis with Nasal Polyps: Tapering Biologics

We are studying whether patients with stable chronic rhinosinusitis can safely reduce their biologic medication dosage after a year. This trial compares the effects of Mepolizumab and Dupilumab on disease control.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Anal High-Grade Lesions: Sinecatechins Ointment

We are studying whether adding a topical ointment to standard treatment helps patients with high-grade anal lesions achieve better results. The goal is to see if it reduces lesions and prevents recurrence.

Anal High-Grade Squamous Intraepithelial Lesions (HSIL)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Rezafungin for Fungal Infections in Critically Ill Patients

We are studying how Rezafungin levels change in patients on ECMO, a life-support treatment. This research aims to understand its effectiveness and any potential side effects.

Invasive Candidiasis>2 yearsConfirmation phase (III)Monitoring phase (IV)16-20 visitsNo PlaceboStandard MedicinesInfectious DiseasesInternal MedicinePulmonology

Chronic Heart Failure: Vitamin D and Oral Iron Study

We are studying whether vitamin D combined with oral iron can improve symptoms in patients with chronic heart failure and iron deficiency. This trial compares it to standard intravenous iron treatment to see which is more effective.

Chronic Heart FailureIron Deficiency3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCardiologyInternal Medicine