Search Clinical Trials in the European Union

1-2 years
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621-640 of 653 trials

Recovery After Gallbladder Surgery: Esmolol vs. Sufentanil

We are comparing two medications to see which one helps patients recover more comfortably after laparoscopic gallbladder surgery. This study aims to improve patient comfort during the recovery process.

Laparoscopic Gallbladder Removal1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and TraumatologyOtolaryngology

Onychomycosis: DexULac® Treatment Study

We are studying how well DexULac® works for treating nail fungal infections and its impact on patients' quality of life. This trial will help us understand the effectiveness and safety of this treatment over time.

Nail Fungus (Onychomycosis)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Spinocerebellar Ataxia SCA27B: Fampridine Study

We are investigating whether fampridine can help improve movement and daily activities in patients with spinocerebellar ataxia SCA27B. This study will also assess its effects on quality of life and overall health.

Spinocerebellar Ataxia1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNeurology

REM0045392: New Medication Study

We are investigating a new medication to see how safe and effective it is compared to a placebo in healthy individuals. This study will help us understand its potential benefits and risks.

Alzheimer's Disease1-2 yearsSafety phase (I)Neurology

Asthma Treatment: AMG 691 Study

We are testing a new medication called AMG 691 in healthy individuals and those with mild-to-moderate asthma. The goal is to see how it compares to a placebo in managing asthma symptoms.

Asthma1-2 yearsSafety phase (I)Internal MedicinePulmonology

High 'Bad' Cholesterol: AZD0780 Study

We are investigating how well AZD0780 works for adults with high LDL cholesterol and heart disease or at risk for it. The goal is to see if it can lower cholesterol levels more effectively than a placebo.

High CholesterolAtherosclerotic Cardiovascular Disease1-2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesCardiologyInternal Medicine

Kidney Transplant: Reduced Immunosuppression for Older Adults

We are studying whether a lower dose of immunosuppressive medication is as effective and safe as the standard dose for older adults after kidney transplantation. This may help improve their overall health and quality of life.

End-stage Renal Disease1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesInternal MedicineNephrology

Advanced Solid Tumors: SNV1521 Treatment Study

We are exploring a new treatment called SNV1521 for individuals with advanced solid tumors. This study aims to determine the safety and appropriate dosage of this medication.

Advanced Solid Tumors1-2 yearsSafety phase (I)Oncology

Nasopharyngeal Carcinoma: Imaging Study with [68Ga]Ga-DOTA-TOC

We are exploring a new imaging method to assess tumors in patients with EBV-related nasopharyngeal carcinoma. This study aims to improve treatment choices by understanding how the tumor responds to therapy.

Nasopharyngeal Carcinoma1-2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Ulcerative Colitis: SAR441566 Study

We are investigating the effects of SAR441566 in adults with moderate-to-severe ulcerative colitis. The study aims to see if different doses can help achieve remission and improve overall health.

Ulcerative Colitis1-2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Primary Aldosteronism: Baxdrostat Study

We are investigating how safe and effective baxdrostat is for adults with primary aldosteronism. The goal is to see if it can improve blood pressure and other health measures compared to a placebo.

Primary Hyperaldosteronism1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesPartially RemoteCardiologyEndocrinologyInternal Medicine

Advanced Colorectal Cancer: OMTX705 Combination Therapy

We are studying a new drug, OMTX705, combined with regorafenib and tislelizumab for patients with advanced colorectal cancer. The goal is to evaluate its safety and effectiveness in those who have not responded to previous treatments.

Metastatic Colorectal Cancer1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Alzheimer’s Disease: KarXT + KarX-EC Treatment

We are studying a new treatment for cognitive impairment in people with mild to moderate Alzheimer’s disease. The trial will check if it helps improve thinking skills and daily activities, while also ensuring safety.

Mild to Moderate Alzheimer's Disease1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesNeurologyPsychiatry

Inflammatory Rheumatic Diseases: JAK Inhibitor Dose Reduction Study

We are exploring if lowering the dose of JAK inhibitors is as effective as keeping the current dose for patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis in low disease activity. This study will also look at safety and how many patients can successfully reduce their medication.

Rheumatoid Arthritis, Psoriatic Arthritis, and Axial Spondyloarthritis1-2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineRheumatology

Choline Alfoscerate for Elderly with Subthreshold Depression

We are studying whether choline alfoscerate can help improve symptoms of subthreshold depression in elderly patients. The trial also looks at its effects on cognitive symptoms and apathy.

Under Threshold Depression in the Elderly1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPsychiatry

Etrasimod in Breastfeeding Women

We are studying how the medication etrasimod is absorbed into the blood and breast milk of healthy lactating women. This research will help us understand its safety and potential effects on breastfeeding infants.

Ulcerative Colitis1-2 yearsSafety phase (I)No PlaceboStandard MedicinesGastroenterologyGynecology and Obstetrics

Obesity Treatment: Orforglipron Tablet Study

We are investigating how well a new daily tablet helps people with obesity or overweight, both with and without type 2 diabetes, in reducing weight and improving blood sugar levels compared to a placebo.

ObesityOverweightType 2 Diabetes1-2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Zelenectide Pevedotin for Advanced Non-small Cell Lung Cancer

We are studying a new treatment for patients with advanced or metastatic non-small cell lung cancer that has NECTIN4 amplification. The goal is to see how well it works and how safe it is for those who have already been treated.

Advanced Non-small Cell Lung Cancer1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesOncology

Ovarian Cancer: COM701 Treatment Study

We are testing the safety and effectiveness of COM701 for patients with relapsed platinum-sensitive ovarian cancer. The study aims to see if it can help patients maintain their health without cancer progression.

Ovarian CancerRecurrent Ovarian Cancer1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteGynecology and ObstetricsOncology

Acromegaly: ALXN2420 Treatment Study

We are studying whether the new drug ALXN2420 can help lower hormone levels and improve symptoms in adults with acromegaly when used with standard treatments. This trial compares ALXN2420 to a placebo to assess its effectiveness.

Acromegaly1-2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinology