Search Clinical Trials in the European Union

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661-680 of 1,743 trials

B-cell Acute Lymphoblastic Leukemia: CD19-CAR T Cell Therapy

We are testing a new type of CAR T cell therapy for children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia. The study aims to evaluate the safety and appropriate dosage of this treatment.

Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesHematologyOncology

Chronic Lymphocytic Leukemia: Acalabrutinib vs. Venetoclax

We are comparing two treatment combinations for newly diagnosed chronic lymphocytic leukemia patients to see which is more effective and safer. We will also look at how these treatments affect patients' quality of life.

Chronic Lymphocytic Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyOncology

Scleroderma: Stem Cell Injections for Digital Ulcers

We are studying if injections of cultured fat cells can help heal stubborn digital ulcers in patients with scleroderma. This trial compares the treatment to a placebo to evaluate its effectiveness and safety.

Systemic Sclerosis>2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementInternal MedicineRheumatology

Breast Cancer: Study of OKI-219 Treatment

We are investigating a new treatment called OKI-219 for patients with breast cancer. This study looks at how it works alone and with other therapies to improve outcomes.

Advanced Breast CancerSolid Tumor>2 yearsSafety phase (I)Oncology

Stroke Treatment Study: Tirofiban vs. Aspirin

We are comparing the effectiveness and safety of tirofiban and aspirin for patients with acute ischemic stroke caused by tandem lesions. This study aims to find out which treatment better prevents complications and improves recovery.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyNeurology

Advanced Solid Tumors: Sigvotatug Vedotin

We are studying a new treatment for patients with advanced solid tumors to see how well it works compared to current options. This research aims to improve outcomes for those affected by these cancers.

Cervical CancerHead and Neck CancerGastric Cancer>2 yearsSafety phase (I)Oncology

Advanced Epithelial Ovarian Cancer: Radspherin® Treatment

We are studying whether Radspherin® can improve survival and quality of life for patients with advanced ovarian cancer and peritoneal metastasis. This trial focuses on those scheduled for chemotherapy and surgery.

Peritoneal Carcinomatosis>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsOncology

Crohn's Disease: New Ultrasound Method with Microbubbles

We are testing a novel ultrasound technique using oral contrast to improve the detection of Crohn's disease complications. This study aims to see if it can identify issues like ulcers and blockages in the small intestine.

Crohn's Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Alport Syndrome: Dapagliflozin for Kidney Health

We are studying whether Dapagliflozin can help slow the progression of kidney disease in adolescents and young adults with Alport syndrome. This trial aims to improve treatment options for those with this condition.

Alport's Syndrome>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNephrology

Chondrosarcoma: Ivosidenib Treatment Study

We are studying the effects of ivosidenib in adults with locally advanced or metastatic chondrosarcoma. This trial aims to see if it improves tumor outcomes and overall survival compared to standard treatments.

Chondrosarcoma>2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteOncology

Seasonal Allergic Rhinitis: PQ Grass Treatment for Kids

We are studying a new treatment for children and teens with seasonal allergic rhinitis caused by grass pollen. The goal is to see if it helps reduce symptoms and is safe for long-term use.

Allergic Rhinitis and Conjunctivitis>2 yearsConfirmation phase (III)>20 visitsStandard MedicinesCost ReimbursementPartially RemoteAllergologyPediatrics

Mechanical Heart Valves: Lower INR Study

We are evaluating if a lower INR range is safer and more effective for patients with bileaflet aortic mechanical valves. This may help reduce bleeding risks associated with current treatment methods.

Aortic Valve Replacement Treatment>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Tonsillitis Treatment: Antibiotic vs. No Treatment

We are studying whether an antibiotic can help reduce symptoms in patients with severe tonsillitis who test negative for Streptococcus group A. This trial compares the antibiotic to usual care without antibiotics.

Tonsilitis>2 yearsMonitoring phase (IV)Standard MedicinesInternal MedicineOtolaryngology

Chronic Heart Failure: COR-1167 Study

We are testing a new medication, COR-1167, to see how safe it is and how the body processes it in people with chronic heart failure and healthy volunteers. This study aims to gather important information about its effects.

Chronic Heart Failure>2 yearsSafety phase (I)CardiologyInternal Medicine

Advanced Head and Neck Cancer: TG4050 Gene Therapy

We are testing a personalized gene therapy for patients with advanced head and neck cancer. The goal is to see if it can improve treatment outcomes compared to standard options.

Head and Neck Squamous Cell Carcinoma>2 yearsSafety phase (I)Efficacy phase (II)OncologyOtolaryngology

Multiple Myeloma: Treatment-Free Interval Study

We are exploring whether a treatment-free interval is safe and effective for newly diagnosed multiple myeloma patients receiving a combination of Daratumumab, Lenalidomide, and Dexamethasone. The study aims to compare the effects of continuous treatment versus a break in therapy.

Multiple Myeloma>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

High-Risk Neuroblastoma: Naxitamab and GM-CSF Treatment

We are studying a new treatment combining naxitamab and GM-CSF for children with high-risk neuroblastoma who have not responded to prior therapies. The trial aims to assess how well this treatment works and its safety.

Recurrent Neuroblastoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteOncologyPediatrics

Metastatic Breast Cancer: FDG-PET/CT vs. Conventional CT

We are studying whether FDG-PET/CT can better monitor treatment response in metastatic breast cancer patients compared to conventional CT. This may help improve survival and quality of life for those involved.

Metastatic Breast Cancer>2 yearsConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Pancreatic Cancer: Gembrax with Folfirinox

We are studying whether adding Gembrax to the standard Folfirinox treatment helps patients with metastatic pancreatic cancer. This trial aims to find out if the combination is more effective than Folfirinox alone.

Metastatic Pancreatic Cancer>2 yearsEfficacy phase (II)GastroenterologyOncology

Graft-Versus-Host Disease: Corticosteroids with ECP

We are studying whether adding extracorporeal photopheresis to corticosteroids helps patients with Grade II acute graft-versus-host disease after stem cell transplantation. This trial compares treatment outcomes and side effects between the two approaches.

Acute Graft-Versus-Host Disease (GVHD)>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology