Search Clinical Trials in the European Union

6-12 months
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61-80 of 397 trials

Acute Myeloid Leukemia: CHIP-AML22 Trial

We are studying new treatment options for children and adolescents with newly diagnosed AML to see if they improve survival and reduce side effects compared to standard therapies.

Acute Myeloid Leukemia6-12 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesHematologyPediatrics

HER2-Positive Oligo-Metastatic Breast Cancer: T-DXd Treatment Study

We are investigating how well T-DXd works in combination with other treatments for patients with HER2-positive oligo-metastatic breast cancer. The study will also look at safety and how it affects cancer markers in the blood.

HER2-Positive Metastatic Breast Cancer6-12 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Acute Pancreatitis: Omega-3 Fatty Acid Infusion

We are studying whether early intravenous omega-3 fatty acids can help reduce organ failure and mortality in patients with acute pancreatitis. This trial compares the effects of omega-3s to standard medical care.

Severe Acute Pancreatitis6-12 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesGastroenterologyInternal Medicine

Multiple Myeloma: Innovative Treatment Approaches

We are studying new methods to monitor multiple myeloma in patients who have not yet been treated. This trial compares different treatment combinations, including a stem cell transplant, to see which is more effective.

Multiple Myeloma6-12 monthsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesHematologyOncology

High-Risk Retroperitoneal Sarcoma: Chemotherapy Before Surgery

We are testing whether chemotherapy before surgery improves outcomes for patients with high-risk retroperitoneal sarcoma. This study compares the effects of preoperative chemotherapy to surgery alone.

Dedifferentiated LiposarcomaLeiomyosarcoma6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Treatment-Resistant Depression: COMP360 Study

We are studying whether two doses of COMP360 can improve symptoms in adults with treatment-resistant depression. This trial includes psychological support to enhance treatment effects.

Major Depressive DisorderTreatment-Resistant Depression6-12 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Peripheral Arterial Disease: New Imaging Agent Study

We are testing a new imaging agent in people with peripheral arterial occlusive disease and healthy volunteers. The goal is to understand its safety and how it distributes in the body.

Critical Limb IschaemiaPeripheral Arterial Occlusive Disease6-12 monthsSafety phase (I)CardiologyInternal Medicine

Triple Negative Breast Cancer: Capecitabine and Pembrolizumab Study

We are studying the effects of capecitabine combined with pembrolizumab in patients with triple negative breast cancer after surgery and chemotherapy. This trial aims to see if this combination improves survival rates compared to standard treatments.

Triple Negative Breast Cancer6-12 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology

Myotonic Dystrophy Type 1: ATX-01 Treatment Study

We are evaluating the safety and effects of ATX-01 in adults with myotonic dystrophy type 1. The study aims to see how it impacts muscle function and daily living activities.

Myotonic Dystrophy6-12 monthsSafety phase (I)Post-Trial Drug AccessInvestigational MedicinesInternal MedicineNeurology

Metastatic Breast Cancer: Sacituzumab Govitecan Study

We are analyzing how well sacituzumab govitecan works for patients with advanced breast cancer. The study will also assess safety and explore biomarkers that may predict treatment response.

Locally Advanced or Metastatic Hormone Receptor Positive Breast Cancer6-12 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology

Chronic Rhinosinusitis: Mepolizumab and Nasal Polypectomy Study

We are investigating whether combining Mepolizumab with in-office nasal polypectomy can improve quality of life for patients with chronic rhinosinusitis. The study will assess symptom relief and safety over time.

Chronic Rhinosinusitis with Nasal Polyps6-12 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Erosive Esophagitis: NEXIUM for Kids

We are studying whether NEXIUM can help maintain healing in children aged 1 to 11 with erosive esophagitis. This trial also looks at how well the medication works and any symptoms during treatment.

Erosive Esophagitis6-12 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyPediatrics

Psilocybin for Cancer-Related Depression

We are studying whether a single dose of psilocybin can help improve mood in adults aged 20-80 with major depression after a cancer diagnosis. Participants will compare its effects to a lower dose to assess changes in depressive symptoms.

Malignant TumorsMajor Depressive Disorder6-12 monthsEfficacy phase (II)Investigational MedicinesPartially RemoteOncologyPsychiatry

Hereditary Ichthyosis: Injectable Gentamicin Study

We are studying whether injectable gentamicin can improve skin scaling and redness in people with hereditary ichthyosis. This trial aims to assess its effects on skin condition and overall quality of life.

Congenital Ichthyosis6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesDermatology

B-Cell Non-Hodgkin’s Lymphoma: Glofitamab and Obinutuzumab Study

We are studying the safety and effectiveness of Glofitamab alone and with Obinutuzumab in patients with relapsed or refractory B-cell Non-Hodgkin’s Lymphoma. This trial aims to find the best dose and understand how these treatments work together.

Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma6-12 monthsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOncology

Chronic Kidney Disease: Patiromer Study

We are testing whether patiromer helps patients with chronic kidney disease better manage their blood pressure and reduce protein in urine. This study aims to improve treatment options for those with advanced kidney disease.

Chronic Kidney Disease6-12 monthsMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementCardiologyNephrology

Atypical Hemolytic Uremic Syndrome: Crovalimab for Kids

We are studying the safety and effectiveness of crovalimab in children with atypical hemolytic uremic syndrome. This trial includes both new patients and those switching from other treatments.

Atypical Hemolytic Uremic Syndrome6-12 monthsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyNephrology

Cholangiocarcinoma: Tinengotinib Study

We are studying the safety and effectiveness of a new oral medication, tinengotinib, for patients with FGFR-altered cholangiocarcinoma that hasn't responded to other treatments. This trial compares tinengotinib to the physician's choice of treatment.

Cholangiocarcinoma6-12 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesPartially RemoteOncology

Postoperative Pain Relief: Ibuprofen and Tramadol Combination

We are studying a new combination treatment for patients with severe pain after surgery to see if it provides better pain relief than tramadol alone and a placebo. This trial aims to assess both effectiveness and safety.

Acute Pain6-12 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

Early Breast Cancer: Elacestrant and Ribociclib Study

We are testing a new treatment combination of elacestrant and ribociclib for patients with hormone-sensitive early breast cancer. The goal is to see if this combination works better than standard therapies before surgery.

Hormone Receptor Positive HER2 Negative Breast Cancer6-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsOncology