Search Clinical Trials in the European Union

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841-860 of 1,743 trials

Advanced Cancer: Targeted Therapy Study

We are evaluating new treatments that specifically target the molecular changes in tumors of patients with advanced or metastatic cancer. The goal is to see how well these therapies work and their safety profile.

Advanced / Metastatic Cancers>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Kidney Transplant Rejection: INTERCEPT Study

We are studying whether adding TCZ to standard treatment helps kidney transplant recipients with chronic rejection maintain better kidney function. The trial also looks at the safety of this treatment and its effects on overall health.

Chronic Active Antibody-Mediated Rejection>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteInternal MedicineNephrology

Glioma Treatment Study: Temozolomide and Lomustine

We are testing a combination of chemotherapy and radiotherapy for patients with newly diagnosed grade 2 or 3 glioma. The goal is to see if this approach improves survival compared to standard treatments.

Newly Diagnosed Glioma>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurologyOncology

Acute Heart Failure: Diuretic Treatment Study

We are investigating the best diuretic strategies for patients with acute heart failure and volume overload. This study aims to improve treatment options for those at risk of diuretic resistance.

Acute Heart Failure>2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteCardiologyInternal Medicine

Acute Myeloid Leukemia: Venetoclax and Azacitidine Treatment

We are studying whether a combination of venetoclax and azacitidine can help clear residual disease in AML patients before a stem cell transplant. This trial also looks at the safety and effectiveness of this treatment approach.

Acute Myeloid Leukemia>2 yearsEfficacy phase (II)Confirmation phase (III)>20 visitsNo PlaceboStandard MedicinesHematologyOncology

Zanamivir for Infants with Complicated Influenza

We are studying how safe and effective intravenous zanamivir is for hospitalized infants under 6 months with complicated influenza. This research aims to understand how the drug works in young children.

Human Influenza>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesPediatrics

HIV Prevention: Long-Acting Injectable Cabotegravir vs. Daily Oral Medication

We are studying whether a long-acting injectable form of cabotegravir is more effective than daily oral medication for preventing HIV in men who have sex with men. This trial aims to understand how well each option works over time and their impact on participants' health and behaviors.

HIV Prevention>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesInternal Medicine

Follicular Lymphoma: Tazemetostat with Lenalidomide and Rituximab

We are studying the safety and effectiveness of tazemetostat combined with lenalidomide and rituximab in adults with relapsed or refractory follicular lymphoma. This trial compares the new treatment to a placebo to see how well it works.

Relapsed/Refractory Follicular Lymphoma>2 yearsConfirmation phase (III)>20 visitsInvestigational MedicinesHematologyOncology

DAY101 for Pediatric Brain Cancer and Solid Tumors

We are studying the effects of DAY101 in children aged 6 months to 25 years with low-grade glioma or advanced solid tumors. The goal is to see if it helps shrink tumors and to assess its safety.

Malignant Glioma>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncologyPediatrics

External Cephalic Version: Propofol vs. Spinal Analgesia

We are comparing the use of Propofol and spinal analgesia for sedation during a procedure to turn breech babies. Our goal is to find out which method has a higher success rate and fewer complications.

External Cephalic Version>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Soft Tissue Sarcomas: HDM201 and Pazopanib Study

We are evaluating a new treatment combining HDM201 and Pazopanib for patients with advanced soft tissue sarcomas. The goal is to understand its clinical impact on those with P53 wild-type tumors.

Soft Tissue Sarcoma>2 yearsSafety phase (I)Efficacy phase (II)Oncology

Prostate Cancer: Personalized Radiotherapy and Hormone Therapy

We are studying whether using AI to customize radiotherapy and hormone treatment can help prostate cancer patients while reducing the overall treatment time. This trial is for those with high-risk localized prostate cancer.

Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

VEXAS Syndrome: Azacitidine Treatment Study

We are studying whether Azacitidine can help reduce symptoms and improve health in patients with VEXAS Syndrome. The trial will also assess the safety of this treatment and its impact on patients' quality of life.

VEXAS Syndrome>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteHematologyRheumatology

Axial Spondyloarthritis and Psoriatic Arthritis: Ixekizumab Study

We are examining how ixekizumab affects inflammation in patients with axial spondyloarthritis and psoriatic arthritis. This study uses whole-body MRI to measure changes in joints and entheses.

Psoriatic ArthritisAxial Spondyloarthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology

Stroke Treatment: Anesthesia vs. Sedation

We are comparing general anesthesia to sedation with high-flow nasal cannula for patients undergoing treatment for acute ischemic stroke. Our goal is to see which method leads to better recovery and fewer complications.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurologyOtolaryngology

Whipple's Procedure: Antibiotic Treatment Comparison

We are studying whether pre-emptive antibiotics can lower the risk of infections after Whipple's surgery compared to standard antibiotic treatment. This trial aims to improve recovery outcomes for patients undergoing this procedure.

Pancreatoduodenectomy with High Risk for Contaminated Bile>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInfectious Diseases

Rectal Cancer Surgery: SGM-101 Imaging Study

We are testing a new imaging agent, SGM-101, to see if it helps surgeons better detect rectal cancer during surgery. This study is for patients with locally advanced or recurrent rectal cancer who are undergoing curative surgery.

Rectal Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesGastroenterologyOncology

Locally Advanced Rectal Cancer: Dostarlimab and Radiotherapy

We are studying a new treatment combining dostarlimab and short-course radiotherapy for patients with specific types of rectal cancer. The goal is to see if this approach helps improve treatment success and quality of life.

Locally Advanced Rectal Cancer with Genetic Deficiencies>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesGastroenterologyOncology

CART19 Cells for Blood Cancers

We are studying the effects of CART19 cells in patients with relapsed or refractory acute lymphoblastic leukemia and non-Hodgkin lymphoma. This research aims to explore new treatment possibilities for these challenging conditions.

Recurrent Acute Lymphoblastic Leukaemia>2 yearsSafety phase (I)HematologyOncology

Bladder Cancer: Mitomycin C Treatment Study

We are studying whether a new way to deliver mitomycin C before bladder surgery can lower the risk of cancer returning or worsening in patients with non-muscle invasive bladder tumors.

Non-Muscle Invasive Bladder Tumors>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology