Search Clinical Trials in the European Union

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881-900 of 3,900 trials

HIV Treatment: Doravirine/Tenofovir/Lamivudine Study

We are studying a combination of medications for people living with HIV who have a history of specific mutations. The goal is to see if this treatment helps maintain viral control and improves health over time.

HIV Disease1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Acute Myeloid Leukemia: DASATINIB Treatment Study

We are evaluating the effectiveness of DASATINIB for patients with acute myeloid leukemia who did not respond to previous treatments. The study aims to see if this medication can help reduce tumors and identify factors that predict response.

Acute Myeloid Leukemia≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Klinefelter Syndrome: Testosterone Treatment in Puberty

We are studying how testosterone replacement therapy affects boys with Klinefelter syndrome during puberty. This includes looking at changes in body composition, growth, and overall development.

Klinefelter Syndrome>2 yearsMonitoring phase (IV)Standard MedicinesEndocrinologyUrology

Heart Surgery: Buckberg vs. Del Nido Cardioplegia

We are comparing two heart protection solutions used during surgery to see which one better safeguards the heart and leads to fewer complications. This study is for patients undergoing isolated myocardial revascularization surgery.

Cardiovascular DiseaseMonitoring phase (IV)No PlaceboStandard Medicines

Advanced Solid Tumors: PF-08046050 Study

We are investigating a new treatment for adults with advanced solid tumors. This study aims to understand how well it works compared to current options.

Small Cell Lung CancerPancreatic CarcinomaColorectal Cancer>2 yearsSafety phase (I)Oncology

Chronic Pain Prevention: Duloxetine for Hernia Surgery

We are studying whether duloxetine can help prevent chronic pain in patients at high risk after inguinal hernia repair. We will also compare its safety to a placebo.

Chronic Pain After Surgery3-6 monthsConfirmation phase (III)Investigational MedicinesPartially RemoteInternal MedicineNeurologyOrthopedics and Traumatology

Lung Cancer: Enhanced Skin Care Management

We are studying if improved skin care can help reduce skin side effects in patients with advanced EGFR-mutated lung cancer receiving amivantamab and lazertinib. This trial compares enhanced care to standard skin management.

EGFR-mutated Advanced or Metastatic Non-small Cell Lung Cancer≤3 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteDermatologyOncology

Colchicine for Heart and Kidney Health in Chronic Kidney Disease

We are studying whether low-dose colchicine can help prevent heart problems and slow kidney disease in people with moderate chronic kidney disease. This trial will also look at the safety of the treatment and its effects on inflammation.

Chronic Kidney Disease>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyNephrology

Advanced Neuroendocrine Cancers: DAREON™-7 Study

We are testing how well different doses of BI 764532 work with chemotherapy for people with advanced neuroendocrine cancers. The goal is to see which doses are best tolerated by patients.

Neuroendocrine CarcinomaExtra-pulmonary Neuroendocrine CarcinomaPulmonary Large Cell Neuroendocrine Carcinoma>2 yearsSafety phase (I)Oncology

Breast Cancer Treatment: OP-1250 vs Standard Care

We are studying a new medication, OP-1250, for people with advanced or metastatic ER+, HER2- breast cancer. The goal is to see if it is safer and more effective than current standard treatments.

Estrogen Receptor Positive Breast CancerConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Stem Cell Transplantation vs. Immunosuppressive Therapy for Systemic Sclerosis

We are studying whether upfront stem cell transplantation is more effective than immunosuppressive medication for early diffuse cutaneous systemic sclerosis. This trial will help us understand the best treatment approach for improving survival and quality of life.

Diffuse Cutaneous Systemic SclerosisMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesRheumatology

Peptide Receptor Radionuclide Therapy: LA-SSA Study

We are investigating how a long-acting medication affects radiation doses in tumors and normal tissues during treatment for certain cancers. This may help improve the effectiveness and safety of future therapies.

Neuroendocrine Tumors (NETs)3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Pancreatic Cancer: FOLFIRINOX3 Treatment

We are testing a chemotherapy combination for patients with advanced pancreatic cancer who cannot undergo surgery. The goal is to see if it is safe and effective as a first treatment option.

Advanced Pancreatic Cancer>2 yearsEfficacy phase (II)Oncology

Rosacea Treatment: Ivermectin Cream vs. Soolantra

We are studying a new ivermectin cream for people with papulopustular rosacea to see if it works better than Soolantra and a cream without active ingredients. The trial will assess how well it reduces bumps and redness on the face.

Papulopustular RosaceaConfirmation phase (III)6-10 visitsInvestigational MedicinesDermatology

Metastatic Castration-Resistant Prostate Cancer: Gedatolisib and Darolutamide Study

We are studying a new combination of gedatolisib and darolutamide for men with metastatic castration-resistant prostate cancer. The trial will evaluate safety, tolerability, and how well this treatment works.

Castration-Resistant Prostate Cancer1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncologyUrology

Acute Myeloid Leukemia: Personalized Treatment Based on FLT3 Mutation

We are studying a new treatment strategy for patients with FLT3-positive AML, using a biomarker to tailor therapy. The goal is to see if this approach improves survival compared to standard treatments.

Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyOncology

Sepsis-Associated Acute Kidney Injury: TIN816 Treatment Study

We are investigating a new treatment, TIN816, for individuals with sepsis-related kidney injury. The study aims to see if it improves kidney function and overall health compared to a placebo.

Sepsis-Related Acute Kidney Injury≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteInternal MedicineNephrology

Acute Myeloid Leukemia: RVU120 with Venetoclax

We are studying a new treatment combining RVU120 and Venetoclax for patients with acute myeloid leukemia who did not respond to earlier therapies. The goal is to assess its safety and effectiveness in improving their condition.

Acute Myeloid Leukemia6-12 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesPartially RemoteHematologyOncology

Sinonasal Carcinoma: Pembrolizumab and Chemotherapy

We are studying the safety and effectiveness of combining pembrolizumab with chemotherapy for patients with locally advanced sinonasal carcinoma. This trial aims to explore new treatment options for better outcomes.

Locally Advanced Sinonasal Carcinoma1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyOtolaryngology

Allergy Relief: Sublingual Immunotherapy for House Dust Mite Allergies

We are studying a new treatment for individuals aged 12-65 with rhinitis or asthma caused by house dust mites. The goal is to see if this therapy can improve allergy symptoms compared to a placebo.

Allergic Rhinitis and Asthma1-2 yearsConfirmation phase (III)Investigational MedicinesAllergologyPulmonology