Search Clinical Trials in the European Union

>2 years
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1161-1180 of 1,743 trials

Relapsing-Remitting Multiple Sclerosis: Ozanimod Study

We are studying how ozanimod may help limit brain changes in people with relapsing-remitting multiple sclerosis. The trial looks at its effects on disease activity, cognition, fatigue, and quality of life.

Multiple Sclerosis>2 yearsMonitoring phase (IV)Neurology

HPV Infections: 2LPAPI® Treatment Study

We are testing a new treatment, 2LPAPI®, for people with high-risk HPV infections to see if it helps clear the virus better than a placebo. The study also looks at safety and how the treatment affects cervical cell health.

Human Papillomavirus Infection>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesGynecology and ObstetricsInfectious Diseases

Sickle Cell Disease: CTX001 Treatment for Kids

We are studying a new gene-editing treatment for children with severe sickle cell disease. The trial aims to evaluate its safety and effectiveness in improving their health.

Sickle Cell Anaemia>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementHematologyPediatrics

RAR-Immune: Nivolumab + Ipilimumab vs. Pazopanib for Advanced Sarcoma

We are studying whether a combination of nivolumab and ipilimumab works better than pazopanib alone for patients with advanced rare sarcomas. This trial will help us understand treatment effectiveness and patient quality of life.

Advanced Rare Sarcomas>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Diabetic Macular Edema: Fluocinolone vs. Dexamethasone Implants

We are comparing two eye implants to see which one better improves vision and is more cost-effective for patients with resistant diabetic macular edema. This study also looks at how these treatments affect quality of life.

Diabetic Macular Oedema>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementOphthalmology

GIST Treatment: Lenvatinib vs. Placebo

We are evaluating whether lenvatinib can help patients with advanced GIST who did not respond to imatinib and sunitinib. This study compares its effects to a placebo to assess its potential benefits.

Metastatic Gastrointestinal Stromal Tumor (GIST)>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesOncology

Early Alzheimer's Disease: NIO752 Study

We are investigating a new medication for people with early Alzheimer's disease to assess its safety and how it works in the body. This study aims to gather important information about the treatment's effects.

Alzheimer's Disease>2 yearsSafety phase (I)Neurology

Advanced Cancers: FS222 Antibody Treatment

We are evaluating a new antibody medication for individuals with advanced cancers to see if it is safe and effective. This study aims to understand how well FS222 works in treating these conditions.

Advanced Cancer>2 yearsSafety phase (I)Oncology

Acute Myeloid Leukemia: Midostaurin and Gemtuzumab Ozogamicin

We are studying a new combination treatment for patients with acute myeloid leukemia to see if it is safe and effective alongside standard chemotherapy.

Acute Myeloid Leukemia>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Breast Cancer: Genomics Guided Therapy Study

We are exploring whether a personalized treatment approach after surgery can improve outcomes for patients with early high-risk breast cancer. This study will assess survival rates and the safety of the new therapy.

Early Breast Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Retinoblastoma: New Treatment Strategies

We are studying the effectiveness of a new chemotherapy method and other conservative treatments for children with retinoblastoma. Our goal is to see how well these treatments control the disease and support visual health.

Retinoblastoma Treatment>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOphthalmology

Colorectal Cancer: New Treatment with 5-Fluorouracil, Panitumumab, and Sotorasib

We are studying a combination of medications for patients with advanced colorectal cancer who cannot receive standard chemotherapy. The goal is to see if this treatment helps control the disease and improves quality of life.

Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Cervical Cancer: Relatlimab and Nivolumab Study

We are exploring whether combining Relatlimab with Nivolumab is more effective than Nivolumab alone for treating locally advanced cervical cancer. This study aims to find better treatment options for patients.

Cervical Cancer>2 yearsEfficacy phase (II)Oncology

Sepsis Treatment: Aminoglycoside Antibiotics and Isolation

We are studying the effects of combining aminoglycoside antibiotics with standard care and the role of protective isolation in critically ill neutropenic patients with sepsis. Our goal is to see how these strategies impact survival and other health outcomes.

Healthy Participants>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Acute Myeloid Leukemia: Molidustat and Ivosidenib Combination

We are investigating whether the combination of molidustat and ivosidenib can effectively treat patients with IDH1-mutated acute myeloid leukemia or myelodysplastic syndrome. This study aims to assess how well this treatment works and its safety.

Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)>2 yearsSafety phase (I)Efficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesHematologyOncology

Colorectal Cancer: New Immunotherapy Treatment

We are studying a combination of Pembrolizumab and a Dendritic Cell Vaccine, followed by other medications, for patients with advanced colorectal cancer that hasn't responded to prior treatments. The goal is to see if this approach improves survival and safety.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesOncology

Asthma Treatment in Children: Salbutamol vs. Combination Therapy

We are studying whether using salbutamol alone is as effective as combining it with ipratropium bromide for treating moderate asthma attacks in children. This trial aims to find out which treatment helps reduce hospital admissions and improves recovery.

Acute Asthma Attack>2 yearsConfirmation phase (III)Investigational MedicinesPediatricsPulmonology

Tacrolimus and Blood Sugar Control in Dialysis Patients

We are studying how tacrolimus affects blood sugar levels in patients on hemodialysis waiting for a kidney transplant. This research may help improve diabetes management in these patients.

Hemodialysis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyNephrology

Rotator Cuff Disease: Botulinum Toxin Treatment

We are studying whether botulinum toxin can help reduce pain and improve function in people with degenerative rotator cuff disease. Participants will be monitored for effectiveness and any side effects over three months.

Shoulder Tendonitis>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesOrthopedics and Traumatology

Advanced Melanoma: Regorafenib Treatment Study

We are studying the effects of regorafenib in patients with advanced melanoma who have already been treated. The goal is to see if it helps control the disease better when combined with other therapies.

Advanced Melanoma>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesDermatologyOncology