Search Clinical Trials in the European Union

≤3 months
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101-120 of 240 trials

ARDS Treatment: Recombinant Human Plasma Gelsolin

We are studying whether intravenous recombinant human plasma gelsolin is safe and may help patients with moderate-to-severe ARDS caused by pneumonia or infections. This trial compares it to a placebo alongside standard care.

Acute Respiratory Distress Syndrome (ARDS)≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementInfectious DiseasesPulmonology

Thyroid Eye Disease: Sirolimus vs. Corticosteroids

We are comparing a new treatment called Sirolimus with corticosteroids for people with active thyroid eye disease. The goal is to see if Sirolimus is more effective and has fewer side effects.

Thyroid Eye Disease≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteEndocrinologyOphthalmology

Recurrent Herpes Labialis: Lipovir® Gel vs. Zovirax® Cream

We are studying whether Lipovir® Gel is as effective and tolerable as Zovirax® Cream for treating recurrent herpes labialis. Participants will also receive a placebo to help us understand the treatments better.

Cold Sores≤3 monthsConfirmation phase (III)Standard MedicinesDermatologyInfectious Diseases

Psilocybin Therapy for Depression in Serious Illnesses

We are studying whether medium/high doses of psilocybin can help reduce depression and anxiety in patients with COPD, ALS, MS, or APD. This research aims to improve their quality of life and support their caregivers.

Chronic Respiratory and Neurological Disorders≤3 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemotePsychiatryPulmonology

Acute Myeloid Leukemia: KO-539 Treatment Study

We are testing a new drug called KO-539 in patients with relapsed or refractory acute myeloid leukemia. The goal is to see if it is safe and effective for those with specific genetic mutations.

Relapsed Acute Myeloid Leukemia≤3 monthsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Dementia: New Treatments for Agitation

We are exploring whether certain psychotropic medications can help reduce agitation in dementia patients who haven't responded to standard treatments. The study also examines potential side effects and personalized treatment methods.

Agitated BehaviorDementia≤3 monthsMonitoring phase (IV)Investigational MedicinesNeurologyPsychiatry

Ovarian Cancer: 5-ALA Imaging Study

We are testing a dye called 5-ALA to see if it helps surgeons find ovarian cancer tumors that regular methods might miss. This study aims to improve tumor detection during surgery.

Ovarian Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsOncologyOtolaryngology

Andersen-Tawil Syndrome: Flecainide Therapy Study

We are exploring whether flecainide alone or in combination with other medications is more effective for managing heart rhythm issues in patients with Andersen-Tawil syndrome and multifocal ectopic contractions.

Andersen-Tawil SyndromeMultifocal Ectopic Purkinje-related Premature Contractions≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiology

Knee Osteoarthritis: Diclofenac vs. Placebo

We are studying how diclofenac affects knee pain compared to a placebo in people with knee osteoarthritis. The trial also looks at how a special script may change patients' pain experiences.

Knee Osteoarthritis≤3 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Treatment-Resistant PTSD: Mifepristone Study

We are investigating whether mifepristone can help reduce symptoms in people with treatment-resistant PTSD. This study compares its effects to a placebo to see if it offers better relief.

Post-traumatic Stress Disorder≤3 monthsEfficacy phase (II)Standard MedicinesPsychiatry

Calcium Absorption: Glycocholate and Butyrate Study

We are testing the safety and tolerability of glycocholate and butyrate in healthy women who have undergone Roux-en-Y gastric bypass. This study aims to see if these substances can help improve calcium absorption.

Postoperative Obesity≤3 monthsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteEndocrinologyGastroenterology

HIV Treatment: Combination Therapy Study

We are investigating a combination of three drugs to see if they can help reactivate HIV in people living with the virus. This study aims to understand the safety and effectiveness of these treatments.

HIV-1≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesInternal Medicine

HIV Research: Topiramate Treatment

We are investigating whether topiramate can help activate hidden HIV in people on antiretroviral therapy. The study also examines the safety of this medication and how various factors may influence its effects.

HIV-1 Infection≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious Diseases

Atrial Fibrillation After Aortic Valve Surgery: Atorvastatin Study

We are investigating whether taking atorvastatin before surgery helps reduce the risk of atrial fibrillation in patients undergoing aortic valve replacement. We also want to see how stopping statins affects complications after surgery.

Atrial Fibrillation and FlutterPatients Undergoing Surgical Aortic Valve Replacement≤3 monthsMonitoring phase (IV)Standard MedicinesCardiology

Idiopathic Bile Acid Diarrhea: Colesevelam Hydrochloride Tablet

We are studying a new tablet for patients with idiopathic bile acid diarrhea to see if it improves stool consistency compared to a placebo. The trial will also evaluate the safety and tolerability of this treatment.

Bile Acid Diarrhoea≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Gentamicin Injection for Cat Scratch Disease Lymphadenitis

We are studying whether an injection of gentamicin can improve symptoms in patients with cat scratch disease lymphadenitis compared to a placebo. This trial also looks at pain relief and lymph node changes over time.

Bartonellosis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInfectious DiseasesInternal Medicine

Cognitive and Motor Function Study: Donepezil in Older Adults

We are investigating whether a medication can improve thinking and movement tasks in elderly volunteers. This study compares the effects of donepezil to a placebo on brain activity and performance.

Neurological Disorders≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurology

Chronic Low Back Pain: Tricortin 1000 Study

We are testing Tricortin 1000 to see if it helps relieve pain better than a placebo and an existing treatment for chronic low back pain. This study aims to improve pain management for those experiencing acute flare-ups.

Low Back Pain≤3 monthsMonitoring phase (IV)≤5 visitsInvestigational MedicinesInternal MedicineOrthopedics and Traumatology

Migraine Prevention in Kids: Rimegepant Study

We are testing a new medication, rimegepant, to see if it helps reduce migraine days in children and adolescents aged 6 to under 18. The study compares its effects to a placebo to understand its potential benefits.

Migraine≤3 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurologyPediatrics

Buprenorphine for Severe Suicidal Thoughts in Major Depression

We are studying whether buprenorphine can help reduce severe suicidal ideas in individuals with major depressive episodes. The trial will compare different doses to find the most effective and safest option.

Clinical Depression≤3 monthsEfficacy phase (II)6-10 visitsStandard MedicinesPsychiatry