Search Clinical Trials in the European Union

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1561-1580 of 1,738 trials

Alzheimer's Disease: NSC001 Medication Study

We are investigating the safety and tolerability of a new medication, NSC001, for people with mild to moderate Alzheimer's disease. This study will help us learn more about how the medication works in the body.

Alzheimer's Disease3-6 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesNeurology

Hematopoietic Cell Transplantation: Comparing Conditioning Regimens

We are comparing two treatment methods for patients receiving stem cell transplants from matched donors. The goal is to see if one method improves recovery rates better than the other.

Hematological Malignancies>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Lung Cancer Treatment: Telisotuzumab Adizutecan with Osimertinib

We are studying a new combination treatment for adults with advanced EGFR-mutated non-small cell lung cancer. The goal is to see if this approach is safer and more effective than current standard treatments.

Non-Small Cell Lung Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Clostridioides difficile Infection: Shorter Vancomycin Treatment

We are studying whether a 5-day course of oral vancomycin is as effective as the standard 10-day treatment for Clostridioides difficile infection. This trial will also assess recovery rates and safety for participants.

Clostridioides difficile Infection6-12 monthsEfficacy phase (II)11-15 visitsInvestigational MedicinesGastroenterologyInfectious Diseases

Schizophrenia and Alcohol Use Disorder: Tirzepatide Study

We are investigating whether tirzepatide can help reduce alcohol consumption in individuals with schizophrenia and alcohol use disorder. This study compares tirzepatide to a placebo to assess its effects.

Schizophrenia and Alcohol Use Disorder6-12 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyPsychiatry

Gastroesophageal Cancer: Sertraline with Immunochemotherapy

We are studying whether adding sertraline can enhance treatment responses in patients with advanced gastroesophageal cancer receiving immunochemotherapy. The trial also looks at safety, quality of life, and depression during treatment.

Gastroesophageal Cancer>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncologyPsychiatry

Advanced Non-Small Cell Lung Cancer: H1-Antihistamine with Immunotherapy

We are studying whether adding an H1-antihistamine to immunotherapy can improve treatment response in patients with advanced non-small cell lung cancer.

Advanced Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyPulmonology

Cholangiocarcinoma: Chemo and Immunotherapy Study

We are exploring a combination of chemotherapy and immunotherapy for patients with locally advanced cholangiocarcinoma before surgery. The study aims to see if this approach can lower the risk of cancer returning after treatment.

Cholangiocarcinoma1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteOncology

Glioblastoma: Dendritic Cell Immunotherapy Study

We are evaluating a new immune therapy for patients with glioblastoma to see if it improves survival and quality of life compared to standard treatments.

Glioblastoma>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboInvestigational MedicinesOncology

Alzheimer's Disease: The ExPlas Study on Plasma Transfusions

We are investigating whether plasma from exercise-trained donors is safe and can improve cognitive function in people with early Alzheimer's disease. This study will help us understand its effects over several years.

Early Symptomatic Phase Alzheimer's Disease>2 yearsEfficacy phase (II)11-15 visitsInvestigational MedicinesInternal MedicineNeurology

Idiopathic Infertility: Metformin Treatment Study

We are investigating whether metformin can improve endometrial function in women with idiopathic infertility. This study aims to explore its effects on fertility and related biological markers.

Female Infertility3-6 monthsEfficacy phase (II)Standard MedicinesEndocrinologyGynecology and Obstetrics

Prostate Cancer: HIFU and Hormone Therapy Study

We are testing a combination of high-intensity focused ultrasound and short-term hormone therapy for men with intermediate-risk localized prostate cancer. The goal is to see if this approach improves cancer control and maintains sexual and urinary functions.

Intermediate Risk Prostate Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOncologyUrology

Medication-Related Osteonecrosis of the Jaw: PENTO Treatment Study

We are investigating whether the PENTO treatment can help heal jaw bone exposure in patients with MRONJ. The study will also look at pain levels, nutrition, and any side effects over time.

Medication-Related Osteonecrosis of the Jaw>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Metastatic Pancreatic Cancer: Valproic Acid and Simvastatin Study

We are studying whether adding valproic acid and simvastatin to standard chemotherapy improves treatment for patients with metastatic pancreatic cancer. This trial also looks at safety and quality of life for participants.

Metastatic Pancreatic CancerEfficacy phase (II)No PlaceboStandard MedicinesOncology

Colon Cancer: Chemotherapy Study for Older Adults

We are comparing two chemotherapy strategies for patients aged 70 and older who have had surgery for stage III colon cancer. The goal is to see which treatment helps prevent cancer from returning.

Colon Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Non-Small Cell Lung Cancer: New Treatment Study

We are testing new investigational treatments for patients with previously treated stage IV non-small cell lung cancer. The study aims to evaluate how well these treatments work and their safety.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Cancer Detection: 68Ga-FAPI PET/CT Imaging Study

We are studying a new imaging method for patients with unclear cancer diagnoses from standard tests. The goal is to see if this new method can provide clearer results and improve diagnosis accuracy.

Suspicion of Cancer or New Tumor Diagnosis>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Patritumab Deruxtecan for Pediatric Solid Tumors

We are studying a new treatment for children with relapsed or refractory solid tumors to see if it is safe and effective. This trial aims to understand how well it works compared to existing options.

HepatoblastomaRhabdomyosarcoma>2 yearsSafety phase (I)Efficacy phase (II)Investigational MedicinesCost ReimbursementOncologyPediatrics

Indocyanine Green in Gynecological Cancer Surgery

We are testing a dye to improve blood flow assessment during surgery for patients with recurrent gynecological cancer. This study aims to see if it helps reduce complications and improve surgical outcomes.

Gynecological CancersPelvic Exenteration>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Durvalumab for Non-Surgical Non-Small Cell Lung Cancer

We are studying the safety and effectiveness of the immunotherapy durvalumab followed by radiation in patients with early stage or locally advanced non-small cell lung cancer. This trial aims to find out if this treatment approach can help those who cannot have surgery.

Non-Small Cell Lung Cancer1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesOncology